Dose- and ApoE Isoform-Dependent Cognitive Injury after Cranial⁵⁶Fe Irradiation in Female Mice

Effects of exposure to 12C and 4He particles on cognitive performance of intact and ovariectomized female rats

“…Rather the subjects exposed to several doses of either particle showed an increase in responding compared to the non-irradiated controls as the reinforcement ratio increased from FR-1 to FR-35. The observation that exposing intact female rats to HZE particles did not decrease performance on a cognitive task is consistent with the results reported by other investigators using exposure to 56 Fe particles (Villasana et al, 2010(Villasana et al, , 2013Raber et al, 2016;Rabin et al, 2013) and by Krukowski et al (2018a) using a simulated galactic cosmic ray pattern. These results with female rats differ from those obtained using intact male subjects exposed to various components of space radiation which show a disruption of cognitive performance (Shukitt-Hale et al, al.,2000Britten et al, 2017;Rabin et al, 2005aRabin et al, , 2015Parihar et al, 2016;Rabin et al, 2009Rabin et al, , 2015Raber et al, 2013).…”

“…The limited data available suggests that females may not respond to exposure to HZE particles similarly to males. Raber and colleagues (Villasana et al, 2010(Villasana et al, , 2013 have shown differences in the effects of exposure to space radiation on the cognitive performance of mice as a function of sex and ApoE isoform. Working with mice exposed to 40 Ca ions, Raber et al (2016) have shown impaired contextual freezing in irradiated female mice compared to irradiated male mice.…”