Effects of Hange-koboku-to (Banxia-houpo-tang) on Neuropeptide Levels in Human Plasma and Saliva

Naito, Takafumi; Itoh, Hidenori; Takeyama, Masaharu

doi:10.1248/bpb.26.1609

Cited by 30 publications

(25 citation statements)

References 33 publications

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“…However, salivary amylase has been considered to be an indicator of sympathetic activation. NPY is co released with norepinephrine and salivary NPY has been detected according to the published literature (Dawidson et al, 1997;Naito et al, 2003;Santavirta et al, 1997). It should be noted that the salivary levels of NPY reported in the literature are very low.…”

Section: Stress Profile Approachmentioning

confidence: 94%

“…Acetylcholine is the traditional indicator of parasympathetic activation however it is not detectable in saliva. VIP is co-released with acetylcholine from parasympathetic nerves which makes it a good indicator of parasympathetic activity or tone (Dawidson et al, 1997;Naito et al, 2003;Santavirta et al, 1997). In addition a statistically significant correlation between salivary NPY and VIP may indicate how well a subject responds to stress since these two hormones have opposite effects with respect to vagal tone.…”

Section: Stress Profile Approachmentioning

confidence: 99%

“…One of the goals of this study is to determine if NPY can differentiate between physical and psychological stress. In order to accomplish this we will try to assay NPY in saliva which is much less invasive than taking blood (Dawidson et al, 1997;Naito et al 2003;Santavirta et al, 1997).…”

Section: Salivary Neuropeptide Y As a Marker For Stressmentioning

confidence: 99%

“…VIP is also detectable in saliva (Dawidson et al, 1997;Naito et al, 2003;Santavirta et al, 1997). In one study comparing patients with Sjogren's syndrome and normal healthy subjects, stress as assessed by a Jenkins Activity Survey was associated with higher salivary VIP concentrations (Santavirta et al, 1997).…”

Section: Salivary Vasoactive Intestinal Peptide As a Marker For Stressmentioning

confidence: 99%

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Salivary VIP concentrations are elevated in humans after acute stress

et al. 2013

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Section: Stress Profile Approachmentioning

confidence: 94%

Section: Stress Profile Approachmentioning

confidence: 99%

Section: Salivary Neuropeptide Y As a Marker For Stressmentioning

confidence: 99%

Section: Salivary Vasoactive Intestinal Peptide As a Marker For Stressmentioning

confidence: 99%

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Salivary VIP concentrations are elevated in humans after acute stress

et al. 2013

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“…[20][21][22] Naito et al have already reported that some Kampo medicines (Rikkunshi-to, Hange-shashin-to, and Hange-koboku-to) modulate plasma ACTH and cortisol levels, which are often used as an indicator of stress, under venipuncture stress. 23) However, it has not been reported previously whether these Kampo medicines affect plasma NPY levels.…”

mentioning

confidence: 96%

Effects of Some Kampo Medicines on Plasma Levels of Neuropeptide Y under Venipuncture Stress

Sato

Katagiri

Takeyama

2005

Biological & Pharmaceutical Bulletin

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Some traditional Chinese herbal (Kampo) medicines have recently been evaluated for their clinical usefulness in stress and depression. These medicines have modulatory effects on the hypothalamic-pituitary-adrenal axis and sympathetic nervous system (SNS). We examined the effects of Rikkunshi-to, Hange-shashin-to, Hangekoboku-to, and Ninjin-to on plasma levels of neuropeptide Y (NPY), which is the representative neurotransmitter of the SNS, under venipuncture stress. Rikkunshi-to and Hange-shashin-to suppressed increases in plasma NPY-immunoreactive substance levels compared with the response to a placebo. In this study, Rikkunshi-to and Hange-shashin-to altered plasma levels of NPY under venipuncture stress. These effects might be benefical in stress-related diseases and our results suggest that these medicines have clinical pharmacologic activity.

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Functional improvement of deglutition after hangekobokuto treatment in two cases: Endoscopy and fluoroscopy evaluation

Nakada¹,

Arai

Kokawa³

et al. 2015

Traditional & Kampo Medicine

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Case Patients with dysphagia frequently suffer from aspiration pneumonia, are frequently hospitalized, and are often deprived of the joys of eating. Although dysphagia is life‐threatening, treatment for dysphagia is still limited. Recently, the effectiveness of hangekobokuto (Banxia‐houpo‐tang in Chinese; HKT) for dysphagia has attracted attention. We treated two dysphagic patients with HKT and evaluated deglutition before and after HKT treatment on imaging. Outcome The first patient was a 69‐year‐old alcoholic liver‐cirrhosis patient who was diagnosed with dysphagia after hospital admission, and the second patient was a 92‐year‐old aspiration pneumonia patient. After treating the chief complaint, HKT (TJ‐16) extract (7.5 g/day) was given and continued indefinitely. Deglutition before and after HKT commencement was evaluated on video endoscopy and video fluoroscopy, respectively. Deglutition after the treatment was monitored visually. Conclusion Deglutition improved after HKT treatment, as judged on endoscopy and fluoroscopy.

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Effects of Hange-koboku-to (Banxia-houpo-tang) on Neuropeptide Levels in Human Plasma and Saliva

Cited by 30 publications

References 33 publications

Salivary VIP concentrations are elevated in humans after acute stress

Salivary VIP concentrations are elevated in humans after acute stress

Effects of Some Kampo Medicines on Plasma Levels of Neuropeptide Y under Venipuncture Stress

Functional improvement of deglutition after hangekobokuto treatment in two cases: Endoscopy and fluoroscopy evaluation

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