Effects of halothane on contraction and intracellular calcium in ventricular myocytes from streptozotocin-induced diabetic rats

Abstract

In contrast to a previous report, we could find no evidence of amelioration of the negative inotropic effect of halothane in myocytes from the STZ-induced diabetic rat. Contractility, the cytosolic Ca(2+) transient, SR Ca(2+) content and myofilament Ca(2+) sensitivity were qualitatively similar in control and STZ myocytes and were all depressed to the same extent by halothane.

Diabetes and the heart: could the diabetic myocardium be protected by preconditioning?

“…For example, Ca 2+ transport and myofilament sensitivity to Ca 2+ were abnormal in cardiomyocytes from STZ-treated rats and further altered in the presence of halothane, suggesting that hearts from the diabetic rats were sensitive to halothane. 129,130 However, abnormal intracellular calcium accumulation and altered myofilament Ca 2+ sensitivity were not observed in another study from the same group. 129,130 Developing new means to overcome the failure to respond to pharmacological preconditioning may generate novel therapeutic strategies aimed at improving the capacity of the myocardium to withstand prolonged ischemia.…”

Influence of Volatile Anaesthetics on Lung Cells and Lung Surfactant

“…1). Studies indicating such typical effect for Ca 2+ ions and disruption of its transport mechanism excited by halothane are reported (41,63). Signifi cant disturbances in both the function and conformation of the Ca…”

Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats

“…; Rithalia et al. ). Action potential (AP) is a hallmark linking directly to myocardial contraction and relaxation, especially tightly linked at the single‐cardiomyocyte level.…”

“…STZ-induced diabetic animal model has been used to investigate DCM in many studies (Teshima et al 2000;Choi et al 2002;Rithalia et al 2004;Singh et al 2006;Aragno et al 2012). Defect in dynamic changes of intracellular calcium ([Ca 2+ ]i) occurred causing reduced cardiac contraction force and relaxation velocity (Choi et al 2002;Rithalia et al 2004). Action potential (AP) is a hallmark linking directly to myocardial contraction and relaxation, especially tightly linked at the single-cardiomyocyte level.…”