Effects of Gynura Procumbens Extract on Liver Function Test of Hypercholesterolemia Induced Rabbits

Abstract

Antioxidant works against oxidant and free radicals is by donating electrons it encompasses to the radical molecules and therefore neutralising the oxidation process in the biological system. Hypercholesterolemia has been identified as one the primary predisposing factor for chronic health diseases in most industrial and developed countries.Hypercholesterolemia contributes to nonalcoholic fatty liver diseases (NAFLD). Gynura procumbens is not toxic and exhibit anti-diabetic, anti-inflammatory, anti-hypertensive and wound healing properties where the extract of this plant contains active chemical constituents such as tannins, terpenoids, sterol glycoside, saponins and flavonoids. New Zealand White Rabbits were fed with high cholesterol diet for ten weeks. Liver weight and serum liver function test (LFT) including ALP, ALT, AST and GGT were determined and analyzed. Rabbits that were given high cholesterol diet show the symptom of liver injury. ALP, ALT, AST and GGT levels indicate the liver injury. Liver injury of rabbits that were supplemented with Gynura procumbens extracts were reduced compared to rabbits that were given high cholesterol diet but not given any supplement of extract. ALP, ALT, AST and GGT level on rabbits were given the extract were improved compared to HCD. Supplementation of the extract lowered the levels of liver enzymes compared to the HCD.

An in vivo and in silico evaluation of the magical hepatoprotective potentialities of Gynura procumbens: a promising agent for combating hepatotoxicity

“…The serum γGT level of the six non-CCl 4 treated groups demonstrated statistically non-significant (p>0.05) deviation from those of the negative control group, signifying the absence of potential menace upon intake of silymarin or G. procumbens . Our findings regarding the serum γGT level restoration efficiency of G. procumbens were quite similar to those of Ismail et al (2016), despite the difference that they performed their experiment employing aqueous extract of G. procumbens [63].…”

An in vivo and in silico evaluation of the hepatoprotective potential of Gynura procumbens: A promising agent for combating hepatotoxicity

“…High doses of our extract have significantly minimized the effect of swelling of hepatocytes, cholestasis, microvesicular and macrovesicular steatosis, lobular inflammation, portal inflammation, and dilatation of sinusoids, etc. Such outcomes were found in several prior studies conducted on Casuarina equisetifolia, Cajanus cajan, Glycosmis pentaphylla, Bixa orellana, Trichosanthes cucumerina, Hygrophila spinosa and Cassia occidentalis [86][87][88].…”

Gynura procumbensLeaf Extract-Loaded Self-Microemulsifying Drug Delivery System Offers Enhanced Protective Effects in the Hepatorenal Organs of the Experimental Rats

“…In addition, it possesses a diverse array of pharmacological actions, including antihyperglycemic, antihyperlipidemic, antioxidant, organ-protective, antibacterial, and anti-inflammatory activity. It is also used for the treatment of hepatotoxicity and alcohol-induced liver disease 18,19 . Many active components (terpenoids, steroids) found in herbal extracts cannot pass through the lipid barrier because they have a high molecular size and low solubility in water 20 .…”