Effects of Gut-Directed Hypnotherapy on IBS in Different Clinical Settings—Results From Two Randomized, Controlled Trials

Lindfors, Perjohan; Unge, Peter; Arvidsson, Patrik; Nyhlin, Henry; Bjõrnsson, Einar; Abrahamsson, Hasse; Simrén, Magnus

doi:10.1038/ajg.2011.340

Cited by 107 publications

(122 citation statements)

References 33 publications

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“…One trial presented the standard deviation of the changes in their report. 20 From these data, we calculated the correlation coefficient by using the following formula. We also used the following formula to calculate the SD of the change by using the correlation coefficient in the studies that did not report this value.…”

Section: Discussionmentioning

confidence: 99%

“…11,[20][21][22][23][24] One study reported 2 RCTs being conducted on different settings in one publication. 20 One of the studies that we initially excluded was published only in abstract form. As we were conducting our meta-analysis, advance online publication of this study was reported in February 2013, so we have included it in our review.…”

Section: Study Selection and Data Extractionmentioning

confidence: 99%

“…Three of the included trials used the Manchester protocol for GDH. 20,24,28 Moser et al delivered GDH in group sessions. 24 Four trials performed GDH with usual medical therapy or supportive talks and medical treatment.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

“…24 Four trials performed GDH with usual medical therapy or supportive talks and medical treatment. 20,23,24 Various methods were used for the control groups. Four trials monitored symptoms only in the control group, [20][21][22][23] and others provided supportive and medical therapy.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

“…23,24 Other type of bias was high in one trial. Four trials used intention-to-treat analysis, 11,20,24 and the others did not.…”

Section: Risk Of Biasmentioning

confidence: 99%

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The Efficacy of Hypnotherapy in the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis

Lee

Choi

2014

J Neurogastroenterol Motil

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Background/AimsHypnotherapy is considered as a promising intervention for irritable bowel syndrome (IBS), but the evidence is still limited. The aims of this study were to conduct a systematic review and meta-analysis to estimate the efficacy of hypnotherapy for the treatment of IBS. MethodsA literature search was performed using MEDLINE (PubMed), Embase, PsycINFO and the Cochrane Central Register of Controlled Trials (CENTRAL database). Only randomized controlled trials that compared hypnotherapy with any other conventional treatment or no treatment in patients with IBS were included. Studies had to report outcomes as IBS symptom score or quality of life. The mean change in outcome score was used to pool these outcomes for the meta-analysis. Data were synthesized using the standardized mean difference for continuous data. ResultsSeven randomized controlled trials (6 papers) involving 374 patients with IBS were identified. Performance bias was high in all trials because it was impossible to blind participants and therapists in this type of intervention. The outcomes in this meta-analysis were evaluated at 3 months for short-term effects and at 1 year for long-term effects. The change in abdominal pain score at 3 months was significant in the hypnotherapy group (standardized mean difference, -0.83; 95% CI, -1.65 to -0.01). Three of the 4 trials showed greater improvement in overall gastrointestinal symptoms in the hypnotherapy group. ConclusionsThis study provides clearer evidence that hypnotherapy has beneficial short-term effects in improving gastrointestinal symptoms of patients with IBS.

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Section: Discussionmentioning

confidence: 99%