Effects of gustatory nerve transection and regeneration on quinine‐stimulated Fos‐like immunoreactivity in the parabrachial nucleus of the rat

King, Camille Tessitore; Deyrup, Leif D.; Dodson, Sara E.; Galvin, Katherine E.; Garcea, Mircea; Spector, Alan C.

doi:10.1002/cne.10851

Cited by 26 publications

(24 citation statements)

References 51 publications

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“…Neurons in the PBN, the second-order gustatory relay station in the rat central gustatory pathway, are known to induce c-fos expression in response to gustatory and visceral stimuli (16,22,23,31,32). The present study showed that PBN neuronal responses at least at the early phase (15 s) of taste stimulation were not altered after the acute blockage of c-fos mRNA translation (Fos protein synthesis) by AS-ODN within the PBN, and that the same treatment did not affect the expression of LiCl-induced Fos-li-positive cells in the CeA.…”

Section: Discussionmentioning

confidence: 99%

Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Yasoshima

Sako

Senba

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 99%

Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Yasoshima

Sako

Senba

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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“…Therefore, the intrinsic signals obtained are mainly the result of stimulation of anterior tongue and palate receptors. However, recent studies showed that, in rats, the neural coding of taste modality depends primarily on the inputs of the facial nerve (anterior tongue and palate), whereas the glossopharyngeal projections (lateroposterior tongue) seem to be more involved in oromotor acceptance/rejection behaviors (King et al, 1999(King et al, , 2003Simon et al, 2006). In addition, all modalities are represented in the anterior part of the oral cavity (Chandrashekar et al, 2006).…”

Section: Methodsmentioning

confidence: 99%

Differential Spatial Representation of Taste Modalities in the Rat Gustatory Cortex

Accolla¹,

Bathellier²,

Petersen³

et al. 2007

J. Neurosci.

178

175

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Discrimination between foods is crucial for the nutrition and survival of animals. Remarkable progress has been made through molecular and genetic manipulations in the understanding of the coding of taste at the receptor level. However, much less is known about the cortical processing of taste sensation and the organizing principles of the gustatory cortex (GC). Using genetic tracing, it has recently been shown that sweet and bitter taste are processed through segregated neuronal circuitries along the gustatory pathway up to the cortical level. This is in disagreement with the evidence that GC neurons recorded in both anesthetized and behaving animals responded to multiple taste modalities (including sweet and bitter). To investigate the functional architecture of the GC in regard to taste modalities, we used in vivo intrinsic optical imaging, a technique that has been successfully applied to explore the organization of other neocortical regions. We found that four of the primary taste modalities (sweet, bitter, salty, and sour) are represented by distinctive spatial patterns but that no region was specific to a single modality. In addition, we found that two tastants of similar hedonic value (pleasant or unpleasant) activated areas with more common regions than two tastants with opposite hedonic value. In summary, we propose that these specific cortical patterns can be used to discriminate among various tastants.

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“…In addition, the characteristic pattern of Fos-like immunoreactivity (FLI) stimulated by quinine in the rostral nucleus of the solitary tract (NST) (see Refs. 11,38) and in the parabrachial nucleus (PBN) that is disrupted by GL transection returns to normal on regeneration of the nerve (12,13).…”

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confidence: 98%

Nerve regeneration-induced recovery of quinine avoidance after complete gustatory deafferentation of the tongue

Geran

Garcea

Spector

2004

American Journal of Physiology-Regulatory, Integrative and Comp

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The concentration-dependent decrease in quinine licking by rats is substantially attenuated by combined bilateral transection of the chorda tympani (CT) and glossopharyngeal (GL) nerves, but transection of either nerve alone produces marginal impairments at most. Here we tested whether regeneration of one or both of these nerves after combined transection would result in recovery of taste avoidance. Water-restricted rats were presented with a series of brief-access (5 s) taste trials (water and 0.003-3.0 mM quinine-HCl) in a 5-day test block of 40-min sessions both before nerve transection and starting 75-77 days after transection. Licking avoidance returned to presurgical levels when both nerves were allowed to regenerate. When only the GL was allowed to regenerate, performance did not differ from that of sham-transected animals. This suggests that even after considerable gustatory deafferentation, regeneration has the capacity to restore normal taste-guided behavior. Surprisingly, when only the CT was allowed to regenerate, avoidance behavior was severely impaired and was not different from that of rats in which regeneration of both nerves was prevented. Taking into account prior findings, it appears that the absence of the GL in the presence of an intact CT is fundamentally different from the absence of the GL in the presence of a regenerated CT with respect to some taste functions. This represents the first reported instance to our knowledge in which the capacity of a regenerated nerve to maintain taste-guided behavior was distinctly different from that of an intact nerve in a rodent model.

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Effects of gustatory nerve transection and regeneration on quinine‐stimulated Fos‐like immunoreactivity in the parabrachial nucleus of the rat

Cited by 26 publications

References 51 publications

Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Acute suppression, but not chronic genetic deficiency, of c- fos gene expression impairs long-term memory in aversive taste learning

Differential Spatial Representation of Taste Modalities in the Rat Gustatory Cortex

Nerve regeneration-induced recovery of quinine avoidance after complete gustatory deafferentation of the tongue

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