Effects of Guanidinoacetic Acid Supplementation to Broiler Diets With Varying Energy Content

Heger, J.; Zelenka, J.; Machander, Vlastislav; Cruz, Carlos de la; Lešták, Martin; Hampel, David

doi:10.11118/actaun201462030477

Cited by 32 publications

(35 citation statements)

References 6 publications

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“…Supplementing 1,200 mg/kg GAA has been shown to improved feed conversion of broilers (Degroot, ; Majdeddin, Golian, Kermanshahi, Smet, & Michiels, ; Michiels et al, ). In further study, supplementation with 600 mg/kg GAA to broiler diets also improved average daily gain (ADG) and feed conversion (Córdova‐Noboa, Oviedo‐Rondón, Sarsour, Barnes, Ferzola et al, ; Heger et al, ; Metwally, Ibrahim, & Khater, ; Pradeep, Radermacher, & Girish, ). And the European Union authorized GAA as a feed additive for chickens for fattening at 600–1,200 mg/kg (EFSA, ).…”

Section: Introductionmentioning

confidence: 93%

“…In further study, supplementation with 600 mg/kg GAA to broiler diets also improved average daily gain (ADG) and feed conversion (Córdova-Noboa, Oviedo-Rondón, Sarsour, Barnes, Ferzola et al, 2018;Heger et al, 2014;Metwally, Ibrahim, & Khater, 2015;Pradeep, Radermacher, & Girish, 2016). And the European Union authorized GAA as a feed additive for chickens for fattening at 600-1,200 mg/ kg (EFSA, 2016).…”

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confidence: 96%

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Effects of guanidinoacetic acid on growth performance, creatine metabolism and plasma amino acid profile in broilers

Yang

et al. 2019

Animal Physiology Nutrition

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The objective of this study was to assess the effects of guanidinoacetic acid (GAA) on growth performance, creatine deposition and blood amino acid (AA) profile on broiler chickens. In Exp. 1, a total of 540 one‐day‐old Arbor Acres male broilers (average initial body weight, 45.23 ± 0.35 g) were divided randomly into five treatments with six replicates of 18 chicks each. Broilers were fed corn–soybean meal‐basal diets supplemented with 0, 600, 800, 1,000 or 1,200 mg/kg GAA for 42 days respectively. Results showed that dietary GAA inclusion increased average daily gain (ADG) and improved gain‐to‐feed ratio (G:F) from 1 to 42 days (p < 0.01). However, average daily feed intake was unaffected by dietary supplementation of GAA. As GAA inclusion increased, the contents of creatine in plasma and kidney were increased (linear, p < 0.01), while the contents of GAA and creatine in liver were decreased (linear, p < 0.01). Similarly, GAA supplementation was inversely related to concentrations of most essential AA in plasma. In Exp. 2, a total of 432 one‐day‐old Arbor Acres male broilers (average initial body weight, 39.78 ± 0.58 g) were divided randomly into four treatments with six replicates of 18 chicks each. Birds were fed a corn–soybean meal‐basal diet supplemented with 0, 200, 400 or 600 mg/kg GAA for 42 days respectively. Dietary inclusion of 600 mg/kg GAA significantly increased ADG and G:F of broilers (p < 0.05). In conclusion, dietary supplementation of 600–1,200 mg/kg GAA can effectively improve the growth performance in broiler chickens by affecting creatine metabolism and utilization efficiency of essential AA, and 600 mg/kg GAA is the minimum dose for improving performance.

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Section: Introductionmentioning

confidence: 93%

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confidence: 96%

Effects of guanidinoacetic acid on growth performance, creatine metabolism and plasma amino acid profile in broilers

Yang

et al. 2019

Animal Physiology Nutrition

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“…Several studies have been conducted for determination of the optimum dietary protein and lipid levels, protein/lipid ratio, carbohydrate/lipid ratio and dietary methionine requirement of the species (Carmona‐Osalde, Olvera‐Novoa, Rodríguez‐Serna & Flores‐Nava, ; Dornelles & Oliveira, ; Huang, Zhang, Wang, Song & Huang, ; Olvera‐Novoa, Ontiveros‐Escutia & Flores‐Nava, ; Zhang, Huang et al., ; Zhang, Feng et al., ). There are several reports indicating the essentiality of GAA supplementation in plant protein‐based diets for broilers (Heger et al., ; Metwally, Ibrahim & Khater, ; Michiels et al., ; Mousavi, Afsar & Lotfollahian, ; Ringel et al., ; Wang, Shi, Shan & Zhang, ); however, to the best of our knowledge, there is no available research on surveying the effects of GAA inclusion in plant‐based diets for aquatic animals. The aim of this study was to investigate whether supplementation of GAA in an all SM diet for bullfrog affects growth performance, antioxidant capacity and muscle energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

Effects of guanidinoacetic acid supplementation in all-plant protein diets on growth, antioxidant capacity and muscle energy metabolism of bullfrogRana(Lithobates)catesbeiana

et al. 2017

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Effects of guanidinoacetic acid (GAA) supplementation in all-plant protein diets were evaluated on growth, antioxidant capacity and muscle energy metabolism of Rana (Lithobates) catesbeiana. Six diets were prepared: a basal fish meal diet (FM), an all soybean meal diet (SM) and four GAA-supplemented diets by adding 0.2, 0.4, 0.6 and 0.8 g GAA/kg to the SM diet (GAA2, GAA4, GAA6 and GAA8 diets). Triplicate groups of bullfrog (45 AE 0.2 g) were fed the diets to apparent satiation for 8 weeks.Total substitution of FM with SM led to significantly (p < .05) reduced growth and feed utilization. Adding 0.4 g GAA/kg to the SM diet significantly improved growth performance, and the values were comparable to those of FM group. SM and GAA2 groups showed drastically lower serum total antioxidant capacity than FM, GAA4 and GAA6 groups. Also, SM and GAA2 groups showed significantly lower catalase activity than FM and GAA8 groups. A remarkable increase in serum malondialdehyde concentration was detected in SM and GAA2 groups. FM and GAA6 groups exhibited significantly higher serum creatinine concentration than other groups.Muscle creatine kinase activity and glycogen content were significantly decreased in SM group and application of 0.4-0.6 g GAA/kg significantly improved their values.GAA4 group showed significantly lower pyruvate kinase activity than FM and GAA6 groups. Also, GAA2 and GAA4 groups had significantly lower succinate dehydrogenase (SDH) activity than other treatments. These findings show that supplementing 0.4 g/kg GAA to SM-based diets improves growth, antioxidant capacity and muscle energy metabolism. K E Y W O R D Sall-plant protein diet, bullfrog, fish meal replacement, growth, guanidinoacetic acid, muscle energy metabolism

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“…In earlier studies, supplementation of GAA improved FCR and with no significant effect on BW gain in broilers (Mousavi et al 2013). Also, supplemental GAA significantly improved FCR and breast meat yield, which might be related to increase muscle levels of creatine (Heger et al 2014). Creatine is necessary for energy haemostasis of cells, especially in birds fed the creatine-deficient diets exclusively based on vegetable ingredients such as corn and soybean meal (Michiels et al 2012).…”

Section: Performance Parametersmentioning

confidence: 99%

Effects of dietary guanidinoacetic acid and betaine supplementation on performance, blood biochemical parameters and antioxidant status of broilers subjected to cold stress

Nasiroleslami

Torki

Saki

et al. 2018

Journal of Applied Animal Research

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This study was conducted to determine the effects of dietary guanidinoacetic acid (GAA) and betaine supplementation on performance, antioxidant status and biochemical parameters of broilers subjected to cold stress. Based on a 2 × 2 factorial arrangement, 384-day-old male broiler chicks (Cobb) were randomly distributed between four experimental diets (with 8 replicates and 12 birds per replicate) included basal diet (as control) and the basal diet supplemented with 1200 mg/kg GAA; 600 mg/kg betaine and 1200 mg/kg GAA + 600 mg/kg betaine. No significant dietary effects were seen on performance, haematological and blood biochemical parameters including plasma glucose, uric acid, total antioxidant status, lactate, lactate dehydrogenase, red blood cell, haemoglobin, haematocrit and heterophil-to-lymphocyte ratios. However, malondialdehyde (MDA), and the activity of creatine kinase (CK), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were affected by the experimental diets. Compared with the other groups, betaine supplementation decreased liver MDA level and SOD activity while increased activity of liver GPx and serum CK and decreased serum level of MDA were observed in birds fed the GAA-included diet. Overall, based on the results, it seems that dietary GAA and betaine could have beneficial effects on antioxidant status of broilers subjected to cold stress. ARTICLE HISTORY

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Effects of Guanidinoacetic Acid Supplementation to Broiler Diets With Varying Energy Content

Cited by 32 publications

References 6 publications

Effects of guanidinoacetic acid on growth performance, creatine metabolism and plasma amino acid profile in broilers

Effects of guanidinoacetic acid on growth performance, creatine metabolism and plasma amino acid profile in broilers

Effects of guanidinoacetic acid supplementation in all-plant protein diets on growth, antioxidant capacity and muscle energy metabolism of bullfrogRana(Lithobates)catesbeiana

Effects of dietary guanidinoacetic acid and betaine supplementation on performance, blood biochemical parameters and antioxidant status of broilers subjected to cold stress

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