Effects of guanidinoacetic acid supplementation in all-plant protein diets on growth, antioxidant capacity and muscle energy metabolism of bullfrogRana(Lithobates)catesbeiana

Zeng, Qiuhui; Wang, Ling; Song, Kai; Lu, Kangle; Zhang, Chunxiao

doi:10.1111/are.13505

Cited by 17 publications

(14 citation statements)

References 50 publications

(63 reference statements)

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“…This is similar to observations reported for other animals. For example, supplementing 0.4 g GDA/kg to the diet significantly improved bullfrog growth performance; however, a further increment of dietary GDA resulted in significant reduction in growth performance (Zeng, Rahimnejad, & Wang, ). The effective and safe dosage of GDA as a dietary additive for broiler chickens has been suggested to be lower than 0.6–0.8 g/kg of diet by the European Food Safety Authority ().…”

Section: Discussionmentioning

confidence: 99%

Evaluation of dietary creatine and guanidinoacetic acid supplementation in juvenile red drumSciaenops ocellatus

2019

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Two separate comparative feeding trials were conducted to evaluate if supplemental dietary guanidinoacetic acid (GDA), either singly or in combination with creatine, could enhance growth performance of red drum. The basal diet for both trials was formulated with practical ingredients but was not supplemented with creatine or GDA. For the experimental diets, creatine (0 or 20 g/kg) and GDA (0, 5 or 10 g/kg) were added to the basal diet in a 2 × 3 factorial arrangement for trial 1. Another 2 × 3 experimental design was adopted in trial 2 to further evaluate creatine (0 or 20 g/kg) and GDA (0, 10 or 20 g/kg) supplementation. Each diet was fed to juvenile red drum in either quadruplicate (trial 1) or triplicate (trial 2) aquaria twice daily for a total of 8 weeks. After each feeding trial, fish were sampled for body condition indices and whole‐body composition analysis, as well as determination of plasma, liver and muscle creatine concentrations. In trial 1, dietary creatine supplementation alone significantly (p < .05) improved weight gain and feed efficiency of red drum. An interaction between creatine and GDA was seen in whole‐body protein and lipid in the two trials. In trial 1, the highest levels of whole‐body protein and lipid were observed in fish fed 10 g GDA/kg, and in trial 2, supplementation of the diet with 10 g GDA/kg increased muscle protein and muscle lipid although there was a trending decline in fish fed the 20 g/kg GDA‐supplemented diet. In both trials of the present study, dietary GDA significantly (p < .05) enhanced liver creatine content. Dietary creatine also significantly (p < .05) enhanced plasma and muscle creatine content of red drum. Based on the results of this study, creatine was effective in enhancing weight gain and feed efficiency of red drum as seen in previous studies; however, GDA was not effective in influencing growth performance but limited synthesis of creatine from dietary GDA was apparent.

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Section: Discussionmentioning

confidence: 99%

Evaluation of dietary creatine and guanidinoacetic acid supplementation in juvenile red drumSciaenops ocellatus

2019

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“…Guanidinoacetic acid (GAA), which is synthesized from the glycine and arginine in the kidney, is the nature precursor of creatine 3,4 . Supplementation with GAA can spare the endogenous synthesis of GAA by arginine and glycine; thus more arginine and glycine can be used for the synthesis of proteins or endogenous amino acids to promote the growth of the body 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Effects of guanidinoacetic acid and complex antioxidant supplementation on growth performance, meat quality, and antioxidant function of broiler chickens

Zhao

Xing

et al. 2021

J Sci Food Agric

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BACKGROUND This study was conducted to evaluate the effects of adding guanidinoacetic acid (GAA), or complex antioxidant (CA), or their combination, in diets on the growth performance, carcass traits, meat quality, and antioxidant capacity of broilers. A total of 192 25‐day‐old broilers were assigned to a 2 × 2 factorial design including two dietary supplements at two different levels, in which the main effects were the addition of GAA (0 or 600 mg kg−1) and CA (0 or 150 mg kg−1). This trial lasted for 18 days. RESULTS Compared with the control group, the GAA group, CA group, and GAA + CA group, decreased feed conversion ratio by 7.02%, 6.58%, and 11.40%, respectively. Guanidinoacetic supplementation increased eviscerated yield, pH24h (P < 0.05). Complex antioxidant supplementation increased the a* values (P < 0.05). The combination of GAA and CA did not affect the carcass traits and meat quality. Guanidinoacetic acid alone and CA alone and combined with GAA and CA decreased the reactive oxygen species (ROS) level and malonaldehyde (MDA) content (P < 0.05), and the GAA + CA group had the lowest ROS level and MDA content of broilers. CONCLUSION Dietary supplementation of GAA, CA or their combination had beneficial effects on growth performance and breast antioxidant capacity, and the combination of GAA and CA could exert a synergistic effect in improving antioxidant capacity. © 2020 Society of Chemical Industry

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“…Zeng et al. (2018) reported that dietary supplementation of 0.4 g GAA/kg to the SM diet significantly improved the growth performance of bullfrog. Fu et al.…”

Section: Discussionmentioning

confidence: 99%

Dietary guanidinoacetic acid response on digestibility, growth performance, feed utilization and carcass quality in Nile Tilapia ( Oreochromis niloticus )

et al. 2020

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Creatine plays a vital part in the energy metabolism and physiological roles. It is exclusively found in ingredients of animal origin, so using all‐plant protein‐based diets increases the risk of creatine deficiency. The objectives of this current study were to determine the optimal level of dietary guanidinoacetic acid (GAA) with regard to the nutrient digestibility, growth performance, feed utilization and carcass quality of Nile tilapia (Oreochromis niloticus). The fish (27.33 ± 0.70 g) were fed with five different isonitrogenous and isoenergetic diets for 60 days: T1 was the positive control diet (HF; 6% fish meal inclusion); T2 was the negative control formulated to contain no GAA (NC, free fish meal); and T3, T4 and T5 were NC supplemented with 0.06%, 0.12% and 0.18% of GAA respectively. At the end of the experiment, it was found that growth performance and feed utilization were not significantly different (p > .05) among the groups. However, fish from the T3 and T4 groups had slightly better weight gain and growth rate, as well as improved digestibility of protein, methionine, lysine and histidine (p < .05). Fish fed the dietary GAA at 0.06 or 0.12% had clearly larger width increment than the other groups. This is important as consumers prefer large dorsal muscles. This result from this study showed no adverse effect on haematological parameters, serum biochemistry parameters, fillet texture quality and histopathological change in the liver of Nile tilapia. Therefore, these results indicate that GAA supplementation at 0.06%–0.12% in Nile tilapia diet can potentially improve fish growth and feed utilization without setback on health.

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Effects of guanidinoacetic acid supplementation in all-plant protein diets on growth, antioxidant capacity and muscle energy metabolism of bullfrogRana(Lithobates)catesbeiana

Cited by 17 publications

References 50 publications

Evaluation of dietary creatine and guanidinoacetic acid supplementation in juvenile red drumSciaenops ocellatus

Evaluation of dietary creatine and guanidinoacetic acid supplementation in juvenile red drumSciaenops ocellatus

Effects of guanidinoacetic acid and complex antioxidant supplementation on growth performance, meat quality, and antioxidant function of broiler chickens

Dietary guanidinoacetic acid response on digestibility, growth performance, feed utilization and carcass quality in Nile Tilapia ( Oreochromis niloticus )

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