Effects of growth environments and two environmental endocrine disruptors on children with idiopathic precocious puberty

Deng, Fang; Tao, Fangbiao; Liu, Deyun; Xu, Yuanyuan; Hao, Jiahu; Sun, Ying; Su, Puyu

doi:10.1530/eje-11-0876

Cited by 64 publications

(40 citation statements)

References 25 publications

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“…Wolff et al (2008) do not find any change in timing of breast development in relation to serum DDE levels in girls in New York city (Table 5). Data on the timing of menarche (Table 6) after prepubertal exposure to DDE (DDT) are discrepant since it has been found to be early (Ouyang et al, 2005;Deng et al, 2012) or normal (Denham et al, 2005;Ozen et al, 2012). However, on account of the persistence of the insecticide in the body fluids, exposure earlier than in prepuberty cannot be excluded in these studies.…”

Section: Critical Windows Of Exposure To Endocrine Disrupters and Timmentioning

confidence: 99%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

157

140

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Puberty presents remarkable individual differences in timing reaching over 5 years in humans. We put emphasis on the two edges of the age distribution of pubertal signs in humans and point to an extended distribution towards earliness for initial pubertal stages and towards lateness for final pubertal stages. Such distortion of distribution is a recent phenomenon. This suggests changing environmental influences including the possible role of nutrition, stress and endocrine disruptors. Our ability to assess neuroendocrine effects and mechanisms is very limited in humans. Using the rodent as a model, we examine the impact of environmental factors on the individual variations in pubertal timing and the possible underlying mechanisms. The capacity of environmental factors to shape functioning of the neuroendocrine system is thought to be maximal during fetal and early postnatal life and possibly less important when approaching the time of onset of puberty.

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Section: Critical Windows Of Exposure To Endocrine Disrupters and Timmentioning

confidence: 99%

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

Parent

Franssen

Fudvoye

et al. 2015

Frontiers in Neuroendocrinology

157

140

View full text Add to dashboard Cite

show abstract

“…Speculations of the origins of such a trend include rapidly changing environmental factors such as chemical exposure [2,4,26] and dietary shifts and a concomitant trend for increased adiposity in children [13].…”

Section: Introductionmentioning

confidence: 99%

Do Secular Trends in Skeletal Maturity Occur Equally in Both Sexes?

Duren

Nahhas

Sherwood

2015

Clinical Orthopaedics &Amp; Related Research

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Background Skeletal maturity assessment provides information on a child's physical development and expectations based on chronological age. Given recently recognized trends for earlier maturity in a variety of systems, most notably puberty, examination of sexspecific secular trends in skeletal maturation is important. For the orthopaedist, recent trends and changes in developmental timing can affect clinical management (eg, treatment timing) if they are currently based on outdated sources. Questions/purposes (1) Has the male or female pediatric skeleton experienced a secular trend for earlier maturation over the past 80 years? (2) Do all indicators of maturity trend in the same direction (earlier versus later)? Methods In this retrospective study, a total of 1240 children were examined longitudinally through hand-wrist radiographs for skeletal maturity based on the Fels method. All subjects participate in the Fels Longitudinal Study based in Ohio and were born between 1930 and 1964 for the ''early'' cohort and between 1965 and 2001 for the ''recent'' cohort. Sex-specific secular trends were estimated for (1) mean relative skeletal maturity through linear mixed models; and (2) median age of maturation for individual maturity indicators through logistic regression and generalized estimating equations. Results Overall relative skeletal maturity was significantly advanced in the recent cohort (maximum difference of 5 months at age 13 years for girls, 4 months at age 15 years for boys). For individual maturity indicators, the direction and magnitude of secular trends varied by indicator type and sex. The following statistically significant secular trends were found: (1) earlier maturation of indicators of fusion in both sexes (4 months for girls,

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“…Эндогенді гормондардың әсерін жаңғырта, шектей немесе өзгерте отырып ГТК репродуктивті функцияның қалыптасу механизміне әсер етуі мүмкін, сондықтан оларды эндокринді деструкторлар деп атайды. Айтылғандарға сүйене отырып, Жер биосферасында гормонтәрізді ксенобиотиктердің пайда болуы ғаламдағы «экологиялық жағдайды» түбегейлі өзгертті деп нақтылауға болады [21][22][23].…”

Section: кіріспеunclassified

“…Сонымен, жүргізілген зерттеулерде [48][49][50], ДДТ және оның метаболиттерінің әсері ерте менархе және телархемен ассоциирленетіндігі көрсетілген. Мичиганда (АҚШ) 151 әйелден құралған топта [51], жатырында ДДЕ деңгейінің 15 μg/L дейін жоғарылауы менархенің орташа жасын 1 жылға қысқарғандығы анықталған.…”

Section: кіріспеunclassified