Effects of gravitational acceleration on cardiovascular autonomic control in resting humans

Fontolliet, Timothée; Pichot, Vincent; Antonutto, G.; Bonjour, Julien; Capelli, Carlo; Tam, Enrico; Barthélémy, Jean‐Claude; Ferretti, Guido

doi:10.1007/s00421-015-3117-9

Cited by 4 publications

(3 citation statements)

References 67 publications

(83 reference statements)

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“…High g-load could initiate early syncopal symptoms, while low g-load could be insufficient to induce strenuous perturbation to hemodynamic homeostasis, and therefore, fails to evoke desired autonomic control of blood pressure. The autonomic control of blood pressure via the conventional approach of arterial baroreflex sensitivity and heart rate variability have been shown to exhibit microgravity or hypergravity induced alteration in the autonomic performance ( Yanagida et al, 2014 ; Fontolliet et al, 2015 ). In this research, we investigated the capability of 1-g and 2-g centrifugation toward evoking autonomic controls of blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge

Verma

Bruner

et al. 2018

Front. Physiol.

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Autonomic control of blood pressure is essential toward maintenance of cerebral perfusion during standing, failure of which could lead to fainting. Long-term exposure to microgravity deteriorates autonomic control of blood pressure. Consequently, astronauts experience orthostatic intolerance on their return to gravitational environment. Ground-based studies suggest sporadic training in artificial hypergravity can mitigate spaceflight deconditioning. In this regard, short-arm human centrifuge (SAHC), capable of creating artificial hypergravity of different g-loads, provides an auspicious training tool. Here, we compare autonomic control of blood pressure during centrifugation creating 1-g and 2-g at feet with standing in natural gravity. Continuous blood pressure was acquired simultaneously from 13 healthy participants during supine baseline, standing, supine recovery, centrifugation of 1-g, and 2-g, from which heart rate (RR) and systolic blood pressure (SBP) were derived. The autonomic blood pressure regulation was assessed via spectral analysis of RR and SBP, spontaneous baroreflex sensitivity, and non-linear heart rate and blood pressure causality (RR↔SBP). While majority of these blood pressure regulatory indices were significantly different (p < 0.05) during standing and 2-g centrifugation compared to baseline, no change (p > 0.05) was observed in the same indices during 2-g centrifugation compared to standing. The findings of the study highlight the capability of artificial gravity (2-g at feet) created via SAHC toward evoking blood pressure regulatory controls analogous to standing, therefore, a potential utility toward mitigating deleterious effects of microgravity on cardiovascular performance and minimizing post-flight orthostatic intolerance in astronauts.

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Section: Discussionmentioning

confidence: 99%

Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge

Verma

Bruner

et al. 2018

Front. Physiol.

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“…Spectral analysis and BRS were analysed by means of a purposely laboratory‐made program written with MATLAB ® software (Version 7·9·1 R2009b) (Costes et al ., ; Assoumou et al ., ; Dauphinot et al ., ; Fontolliet et al ., ).…”

Section: Experimental Methodsmentioning

confidence: 97%

“…For each subject, the mean slope of the RR versus SAP relationships was then computed and taken as a measure of individual BRS, at rest and at exercise, respectively. Spectral analysis and BRS were analysed by means of a purposely laboratory-made program written with MATLAB â software (Version 7Á9Á1 R2009b) (Costes et al, 2004;Assoumou et al, 2012;Dauphinot et al, 2013;Fontolliet et al, 2015).…”

Section: Data Treatmentmentioning

confidence: 99%

Heart rate variability and baroreflex sensitivity in bilateral lung transplant recipients

Fontolliet

Gianella

Pichot

et al. 2018

Clin Physio Funct Imaging

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The effects of lung afferents denervation on cardiovascular regulation can be assessed on bilateral lung transplantation patients. The high-frequency component of heart rate variability is known to be synchronous with breathing frequency. Then, if heart beat is neurally modulated by breathing frequency, we may expect disappearance of high frequency of heart rate variability in bilateral lung transplantation patients. On 11 patients and 11 matching healthy controls, we measured R-R interval (electrocardiography), blood pressure (Portapres ) and breathing frequency (ultrasonic device) in supine rest, during 10-min free breathing, 10-min cadenced breathing (0·25 Hz) and 5-min handgrip. We analysed heart rate variability and spontaneous variability of arterial blood pressure, by power spectral analysis, and baroreflex sensitivity, by the sequence method. Concerning heart rate variability, with respect to controls, transplant recipients had lower total power and lower low- and high-frequency power. The low-frequency/high-frequency ratio was higher. Concerning systolic, diastolic and mean arterial pressure variability, transplant recipients had lower total power (only for cadenced breathing), low frequency and low-frequency/high-frequency ratio during free and cadenced breathing. Baroreflex sensitivity was decreased. Denervated lungs induced strong heart rate variability reduction. The higher low-frequency/high-frequency ratio suggested that the total power drop was mostly due to high frequency. These results support the hypothesis that neural modulation from lung afferents contributes to the high frequency of heart rate variability.

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Influence of Artificial Microgravity on Human Arterial Vessels

et al. 2019

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Effects of gravitational acceleration on cardiovascular autonomic control in resting humans

Cited by 4 publications

References 67 publications

Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge

Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge

Heart rate variability and baroreflex sensitivity in bilateral lung transplant recipients

Influence of Artificial Microgravity on Human Arterial Vessels

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