Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice

Tikhonova, Maria; Tikhonova, N. G.; Тендитник, М. В.; Ovsyukova, M. V.; Akopyan, Anna A.; Дубровина, Н. И.; Amstislavskaya, Tamara G.; Хлесткина, Е. К.

doi:10.3390/molecules25225339

Cited by 22 publications

(16 citation statements)

References 49 publications

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“…In this work, we have demonstrated for the first time that CJ treatment decreased α-synuclein expression in the midbrain of rats co-treated with CJ and ROT. Experimental evidence has shown that rich in PACs grape products significantly decreased the α-synuclein accumulation in the frontal cortex of transgenic mice with overexpression of the A53T-mutant human cells [ 37 ] and in ROT-treated human neuroblastoma-derived cells [ 36 ]. Oxidative stress is suggested to play a crucial role in PD pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson’s Disease

et al. 2022

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Rich in polyphenols, cranberry juice (CJ) with high antioxidant activity is believed to contribute to various health benefits. However, our knowledge of the neuroprotective potential of cranberries is limited. Previously, we have demonstrated that CJ treatment controls oxidative stress in several organs, with the most evident effect in the brain. In this study, we examined the capability of CJ for protection against Parkinson’s disease (PD) in a rotenone (ROT) rat model. Wistar rats were administered with CJ in a dose of 500 mg/kg b.w./day (i.g.) and subcutaneously injected with ROT (1.3 mg/kg b.w./day). The experiment lasted 45 days, including 10 days pre-treatment with CJ and 35 days combined treatment with CJ and ROT. We quantified the expression of α-synuclein and apoptosis markers in the midbrain, performed microscopic examination, and assessed postural instability to evaluate the CJ neuroprotective effect. Our results indicate that the juice treatment provided neuroprotection, as evidenced by declined α-synuclein accumulation, Bax and cleaved/active caspase-9 expression, and normalized cytochrome c level that was accompanied by the enhancement of neuronal activity survival and improved postural instability. Importantly, we also found that long-term administration of CJ alone in a relatively high dose may exert a deleterious effect on cell survival in the midbrain.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson’s Disease

et al. 2022

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“…Flavonoids have been shown to reverse cognitive impairments and inhibit the progression of Alzheimer's disease, implying that they may have therapeutic potential [ 105 ]. Flavonoid-rich diets including grape juice, cocoa, and blueberry are used as memory enhancers [ 82 , 106 , 107 ]. In a randomized controlled clinical study, daily ingestion of anthocyanin-rich cherry juice improved fluency, short-term memory, and long-term memory in aged people (70+) with dementia [ 108 ].…”

Section: Role Of Flavonoids In Neuroprotectionmentioning

confidence: 99%

Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer’s Disease

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et al. 2022

Oxidative Medicine and Cellular Longevity

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Alzheimer’s disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are associated with its pathogenesis that affect neuronal cells to degenerate over the period of time. AD is characterized by cognitive dysfunctions, behavioural disability, and psychological impairments due to the accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles (NFT). Several research reports have shown that flavonoids are the polyphenolic compounds that significantly improve cognitive functions and inhibit or delay the amyloid beta aggregation or NFT formation in AD. Current research has uncovered that dietary use of flavonoid-rich food sources essentially increases intellectual abilities and postpones or hinders the senescence cycle and related neurodegenerative problems including AD. During AD pathogenesis, multiple signalling pathways are involved and to target a single pathway may relieve the symptoms but not provides the permanent cure. Flavonoids communicate with different signalling pathways and adjust their activities, accordingly prompting valuable neuroprotective impacts. Flavonoids likewise hamper the movement of obsessive indications of neurodegenerative disorders by hindering neuronal apoptosis incited by neurotoxic substances. In this short review, we briefly discussed about the classification of flavonoids and their neuroprotective properties that could be used as a potential source for the treatment of AD. In this review, we also highlight the structural features of flavonoids, their beneficial roles in human health, and significance in plants as well as their microbial production.

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“…Grape is an evident example of fruits that contain a high content of polyphenols [59]. Dietary supplement of grape polyphenol concentrate at 1.5 mL/kg significantly enhanced memory reconsolidation in transgenic mouse model of PD [60]. Curcumin is a polyphenol present in turmeric (Curcuma longa) root, which is a yellow pigment used in curry.…”

Section: Polyphenols In Neurodegenerative Diseasesmentioning

confidence: 99%

Dietary Anti-Aging Polyphenols and Potential Mechanisms

et al. 2021

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For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, and decreasing morbidities. With the assistance of basic research investigating the potential mechanisms, it has become clear that the beneficial effects of plant-based foods are mainly due to the large amount of bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies in humans have supported that the supplementation of polyphenols have various health-promoting effects, especially in the elderly population. In vitro examinations on the anti-aging mechanisms of polyphenols have been widely performed, using different types of natural and synthetic phenolic compounds. The aim of this review is to critically evaluate the experimental evidence demonstrating the beneficial effects of polyphenols on aging-related diseases. We highlight the potential anti-aging mechanisms of polyphenols, including antioxidant signaling, preventing cellular senescence, targeting microRNA, influencing NO bioavailability, and promoting mitochondrial function. While the trends on utilizing polyphenols in preventing aging-related disorders are getting growing attention, we suggest the exploration of the beneficial effects of the combination of multiple polyphenols or polyphenol-rich foods, as this would be more physiologically relevant to daily life.

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Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice

Cited by 22 publications

References 49 publications

Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson’s Disease

Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson’s Disease

Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer’s Disease

Dietary Anti-Aging Polyphenols and Potential Mechanisms

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