Effects of Granulocyte Colony Stimulating Factor and Monobactam Antibiotics (Aztreonam) on Neutrophil Functions in Sepsis

Goya, Tadanobu; Torisu, Motomichi; Doi, Fukashi; Yoshida, Takeshi

doi:10.1006/clin.1993.1181

Cited by 26 publications

(15 citation statements)

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“…Our findings suggest that the mechanism of any added In these studies, rG-CSF was efficacious, whether administered prophylactically or therapeutically. Enhanced neutrophil recruitment to the site of infection [29], attenuation of the systemic TNF inflammatory response [29][30][31] and, possibly, synergism with antibiotic therapy [13,32] are suggested mechanisms for the protective or therapeutic action of rG-CSF. It was initially feared that administration of rhG-CSF to patients with sepsis might lead to or aggravate ARDS, through rhG-CSF-induced enhancement of neutrophil recruitment to sites of infection.…”

Section: Discussionmentioning

confidence: 99%

Effects of granulocyte colony-stimulating factor (G-CSF) treatment on granulocyte function and receptor expression in patients with ventilator-dependent pneumonia

Hustinx

Kessel

Heezius

et al. 1998

Clinical and Experimental Immunology

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Considerable experimental evidence in animals suggests that treatment with G‐CSF may have a beneficial effect in the management of severe infections in non‐neutropenic hosts. This beneficial effect is attributed to an enhancement of granulopoiesis and neutrophil function, the latter possibly involving up‐regulation of receptors on neutrophils that are involved in antibody‐mediated cytotoxicity and killing of microorganisms. We compared neutrophil function and phenotype in blood and bronchoalveolar lavage fluid (BALF) of 10 patients with severe ventilator‐dependent pneumonia, at baseline and following initiation of G‐CSF treatment as adjunct to standard therapy. G‐CSF treatment was associated with three‐fold increased blood neutrophil counts at day 3 of treatment compared with baseline counts. Mean serum G‐CSF concentration increased from 313 to 2007 pg/ml. After correction for lavage dilution effects, BALF G‐CSF levels did not differ significantly from baseline, nor did neutrophil receptor expression (FcγRI, FcγRII, FcγRIII, CR3, and L‐selectin) or indicators of neutrophil function such as respiratory burst activity, phagocytosis and killing of Candida albicans in BALF or blood. The mortality in this group of patients was 30% and compared favourably to the APACHE II‐derived predicted mortality of 60%. We conclude that the possible therapeutic benefit of G‐CSF administration in the early phase of severe bacterial pneumonia is not readily explained by its effect on baseline indicators of neutrophil function or receptor expression.

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Section: Discussionmentioning

confidence: 99%

Effects of granulocyte colony-stimulating factor (G-CSF) treatment on granulocyte function and receptor expression in patients with ventilator-dependent pneumonia

Hustinx

Kessel

Heezius

et al. 1998

Clinical and Experimental Immunology

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“…In non-neutropenic experimental sepsis, G-CSF improved neutrophil function [15], which may protect from secondary infections, reduced TNF levels [16,17], which might alleviate both the proinflammatory reaction itself and facilitate the counter-inflammatory response, and improved survival [17]. G-CSF has been safely administered to intensive care unit (ICU) patients without excess risk for the development of organ dysfunction in several studies [18 -20], including ours [21].…”

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confidence: 99%

Granulocyte colony-stimulating factor therapy and systemic inflammation in critically ill patients

et al. 2005

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“…As supportive evidence obtained in in vitro experiments, antibiotics have sometimes been found to activate neutrophil functions such as chemotaxis (2,3,21,23), adherence (2,6,18), phagocytosis (9,11,17), and enzyme release (13). Moreover, in vivo experiments have demonstrated that granulocyte-colony stimulating factor (G-CSF) augments in vivo antibacterial activities of certain antibiotics (5,24,25).…”

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confidence: 89%

Reduced Anti‐Pseudomonas aeruginosa Activity of a Cephalosporin, Cefodizime, in Rats Whose Neutrophils Were Selectively Depleted by a Monoclonal Antibody

Araki

Sendo

1996

Microbiology and Immunology

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In order to clarify the mechanisms of the in vivo antibacterial activity of a cephalosporin, cefodizime (CDZM), the effect of this antibiotic on Pseudomonas aeruginosa E7 infection was examined in rats whose neutrophils had been selectively depleted by monoclonal antibody RP-3. CDZM was less effective in RP-3-treated rats than in untreated rats. However, treatment of rats with recombinant human granulocyte-colony stimulating factor (rhG-CSF) augmented the in vivo activity of this antibiotic. Furthermore, the in vivo antibacterial activity of two other cephalosporins, cefpimizole (CPIZ) and cefoperazone (CPZ), was bilaterally affected by a rise or fall in the neutrophil number, although to a lesser degree than was the case with CDZM. Taken together, neutrophils play an important role in the in vivo antibacterial activity of certain cephalosporins.

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Effects of Granulocyte Colony Stimulating Factor and Monobactam Antibiotics (Aztreonam) on Neutrophil Functions in Sepsis

Cited by 26 publications

References 0 publications

Effects of granulocyte colony-stimulating factor (G-CSF) treatment on granulocyte function and receptor expression in patients with ventilator-dependent pneumonia

Effects of granulocyte colony-stimulating factor (G-CSF) treatment on granulocyte function and receptor expression in patients with ventilator-dependent pneumonia

Granulocyte colony-stimulating factor therapy and systemic inflammation in critically ill patients

Reduced Anti‐Pseudomonas aeruginosa Activity of a Cephalosporin, Cefodizime, in Rats Whose Neutrophils Were Selectively Depleted by a Monoclonal Antibody

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