Reduced Anti‐Pseudomonas aeruginosa Activity of a Cephalosporin, Cefodizime, in Rats Whose Neutrophils Were Selectively Depleted by a Monoclonal Antibody

Abstract

In order to clarify the mechanisms of the in vivo antibacterial activity of a cephalosporin, cefodizime (CDZM), the effect of this antibiotic on Pseudomonas aeruginosa E7 infection was examined in rats whose neutrophils had been selectively depleted by monoclonal antibody RP-3. CDZM was less effective in RP-3-treated rats than in untreated rats. However, treatment of rats with recombinant human granulocyte-colony stimulating factor (rhG-CSF) augmented the in vivo activity of this antibiotic. Furthermore, the in vivo antibacterial activity of two other cephalosporins, cefpimizole (CPIZ) and cefoperazone (CPZ), was bilaterally affected by a rise or fall in the neutrophil number, although to a lesser degree than was the case with CDZM. Taken together, neutrophils play an important role in the in vivo antibacterial activity of certain cephalosporins.

Immunomodulating effects of cefodizime on Klebsiella pneumoniae-stimulated neutrophils

“…It is believed that neutrophils play an important role in the activity of cefodizime (Araki and Sendo, 1996).…”