1996
DOI: 10.1111/j.1348-0421.1996.tb01076.x
|View full text |Cite
|
Sign up to set email alerts
|

Reduced Anti‐Pseudomonas aeruginosa Activity of a Cephalosporin, Cefodizime, in Rats Whose Neutrophils Were Selectively Depleted by a Monoclonal Antibody

Abstract: In order to clarify the mechanisms of the in vivo antibacterial activity of a cephalosporin, cefodizime (CDZM), the effect of this antibiotic on Pseudomonas aeruginosa E7 infection was examined in rats whose neutrophils had been selectively depleted by monoclonal antibody RP-3. CDZM was less effective in RP-3-treated rats than in untreated rats. However, treatment of rats with recombinant human granulocyte-colony stimulating factor (rhG-CSF) augmented the in vivo activity of this antibiotic. Furthermore, the i… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2004
2004
2004
2004

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 21 publications
0
1
0
Order By: Relevance
“…It is believed that neutrophils play an important role in the activity of cefodizime (Araki and Sendo, 1996).…”
Section: Article In Pressmentioning
confidence: 99%
“…It is believed that neutrophils play an important role in the activity of cefodizime (Araki and Sendo, 1996).…”
Section: Article In Pressmentioning
confidence: 99%