Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

Jeong, Jae-Kwan; Choi, In Soo; Kang, Hyun Gu; Hur, Tai Young; Kim, Ill-Hwa

doi:10.4142/jvs.2016.17.4.577

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…The AI number may affect CR; differences in CR between AI number groups have been reported in zebu cattle (Mollah, Gofur, Asaduzzaman, & Bhuiyan, ). In addition, other factors have been associated with CR in other beef cattle breeds and in dairy cattle, these include the following: age of heifers at first AI, parity, interval from calving to first AI, and AI season (Jeong, Choi, Kang, Hur, & Kim, ; Kruif, ; Kuhn, Hutchison, & Wiggans, ; Maufti, Alam, Sarker, Bostami, & Das, ; Sharifuzzaman, Barman, Matin, Rokonuzzaman, & Ashadul, ; Shiddiqui et al., ). Yet, there have been no studies investigating the effects of interactions between AI number and these other factors on CR in Japanese Black cattle.…”

Section: Introductionmentioning

confidence: 99%

Effects of service number on conception rate in Japanese Black cattle

Irikura

Uematsu

Kitahara

et al. 2017

Reprod Domestic Animals

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The conception rate (CR) of Japanese Black cattle has been decreasing since 1990. The objectives of this study were to compare CR by artificial insemination (AI) number, and to assess the interaction between AI number and possible factors related to CR in Japanese Black cattle. Records of 11,182 AI records for 6,741 heifers and 61,302 AI records for 13,139 cows on 977 farms were analysed. The average CR of heifers was 47.0%, and CR at the first, second and third AI was higher than at the fourth or subsequent AI (p < 0.05). The average CR of cows was 47.8%, and their CR at first and second AI was higher than the fourth or subsequent AI (p < 0.05). Data analysis with CR as the dependent variable revealed significant interactions of AI number with interval from calving to first AI and AI season. Cows first serviced at ≤48 days post-partum had lower CR than those at ≥90 days at first AI (p < 0.05), but the interval from calving to first AI did not affect CR at second AI. Cows serviced in the autumn had a higher CR at first AI than those serviced in the spring and winter (p < 0.05); however, there was no seasonal difference in CR at the second AI. In summary, CR began to decrease from the fourth AI in heifers and the third AI in cows. The AI season and the interval from calving to first AI significantly affected CR only at the first AI.

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Section: Introductionmentioning

confidence: 99%

Effects of service number on conception rate in Japanese Black cattle

Irikura

Uematsu

Kitahara

et al. 2017

Reprod Domestic Animals

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“…A recent study ( Jeong et al, 2016) revealed that GnRH administration after 5 days of timed AI in dairy cows resulted in the ovulation of a dominant follicle (DF) and formation of an accessory CL. Similar results were observed with the administration of hCG on Day 5 in cows (Schmitt et al, 1996a;Hanlon et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Effect of Different Hormonal Therapies on Day 5 of Estrus on Plasma Progesterone Profile and Conception Rates in Repeat Breeding Dairy Cows

Kumar¹,

Purohit²

2017

J. Anim. Health Prod.

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| The effect of treatment with a gonadotrophin-releasing hormone (GnRH) analogue-Buserelin acetate, human chorionic gonadotrophin (hCG) and exogenous hydroxy-progesterone caproate on plasma progesterone profile and conception rates was investigated in 44 repeat breeding dairy cattle. Repeat breeding dairy cows on Day 5 post artificial insemination were randomly assigned to four groups: control (no treatment, n=11), Inj GnRH analogue (buserelin acetate, 20µg, n=11), Inj hCG (3000 IU, n=11), or Inj hydroxy progesterone caproate (500 mg, n=11) administered once IM. Progesterone concentration (ng/ml) was determined in plasma of cows on Day 0, 5, 12 and 19, and pregnancy diagnosis was undertaken on Day 60 by rectal palpation. The plasma progesterone concentrations on the Day of insemination were not significantly different between the treatment groups. The plasma progesterone concentration increased significantly (P<0.01) on Day 5 in all cows in all groups. On Day 5 the differences between different treatment groups were non significant. The plasma progesterone concentrations one week after treatment i.e. on Day 12 were significantly higher compared to values on Day 5 in treatment GnRH and treatment hCG (P<0.01). In progesterone treatment and untreated control cows although the plasma progesterone concentrations increased from 2.12±0.25 ng/ml on Day 5 to 4.99±0.23 ng/ml on Day 12 in progesterone treatment and 2.02±0.08 ng/ml on Day 5 to 4.24±0.23 ng/ml on Day 12 in control cows, the differences were non significant. GnRH and hCG treatments increased the plasma progesterone and this probably supported the higher conception rates in these groups. On Day 19 the plasma progesterone concentrations were significantly higher (P<0.01) in all groups compared to progesterone profile on Day 0 and significantly higher (P<0.01) compared to concentrations on Day 5 in GnRH and hCG treatments. When compared to concentrations on Day 12 the progesterone concentration decreased significantly (P<0.01) in hCG treated cows on day 19. Transrectal palpation after treatment in treated cows revealed the formation of accessory corpus luteum in 27.27% cows in GnRH treated, 0% in progesterone treated, and 36.36% in hCG treated cows. The pregnancy rates were highest in hCG treatment (45.45%) followed by GnRH (36.36%) and progesterone (27.27%) compared to untreated control cows (18.18%). It was concluded that the hormonal therapies on Day 5 post insemination increase the plasma progesterone concentration and conception rates in repeat breeding dairy cattle with hCG treatment being the best.

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“…In a study by Khoramian et al (2011), hCG and controlled internal drug release (CIDR) applications after AI in repeat breeder cows led to higher conception rates. Application of CIDR following AI between days 5-12 (Hokmabad et al 2012), days 5-9 (Ghasemzadeh-Nava et al 2007) and days 3.5-18 (Jeong et al 2016) was reported to be successful in increasing the conception rate. Garcia-Ispierto and López-Gatius (2017) reported that progesterone supplementation either early (3-5 days) or late (15-17 days) in the cycle increased the conception rate.…”

Section: Discussionmentioning

confidence: 99%

“…In these hormonal applications following AI, there may be differences between the rates of conception (Yan et al 2016). Some studies have reported that progesterone supplementation (Ghasemzadeh-Nava et al 2007;Jeong et al 2016;Parr et al 2017) and hCG administration (Kendall et al 2009;Khoramian et al 2011;Sánchez et al 2018) increase the pregnancy rate, while some studies (Shams-Esfandabadi and Shirazi 2007; Ergene 2012) have reported no effect. Yan et al (2016) reported that the benefit of progesterone supplementation on fertility of cows required exogenous progesterone supplementation to start between Day 3 to 7.…”

mentioning

confidence: 99%

Effect of progesterone, human chorionic gonadotropin and progesterone + human chorionic gonadotropin treatment on conception rates in repeat breeder cows

Alkan

Erdem

2020

Acta Vet. Brno

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The aim of this study was to investigate the effects of hormonal support on the pregnancy rate in repeat breeder cows. Prostaglandin F2α + Ovsynch oestrus synchronization protocol was applied to the cows. Following the fixed time insemination (day 0), the cows were divided into 4 groups. In Group 1 (n = 42), progesterone releasing intravaginal device (PRID) was placed vaginally at 84 h and removed on the 9th day after the artificial insemination. In Group 2 (n = 40), the cows were administered human chorionic gonadotropin (hCG) on the 7th day. Group 3 (n = 45) was applied a combination of progesterone and hCG. Group 4 (n = 42) was not given any treatment. Blood samples were collected from all cows 4 times on days 3.5, 7, 12, and 18 to evaluate progesterone concentrations. The pregnancy rates were 40.47%, 37.50%, 44.44%, and 30.95% in Group 1, 2, 3, and 4, respectively (P > 0.05). In addition, in cows with progesterone concentrations <2 ng/ml on day 3.5, the pregnancy rates were found to be lower than in the cows with progesterone concentrations >2 ng/ml in Group 4 (P < 0.05). Progesterone supplementation in cows with progesterone concentrations < 2 ng/ml appeared to increase pregnancy rates (P < 0.05) in Groups 1 and 3. As a result, post-insemination hormonal applications in the repeat breeder cows did not increase the pregnancy rate. However, it was concluded that determination of progesterone concentrations on day 3.5 following artificial insemination and then hormonal support in the cows with low concentrations would increased the pregnancy rate.

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Effects of gonadotropin-releasing hormone administration or a controlled internal drug-releasing insert after timed artificial insemination on pregnancy rates of dairy cows

Cited by 7 publications

References 35 publications

Effects of service number on conception rate in Japanese Black cattle

Effects of service number on conception rate in Japanese Black cattle

Effect of Different Hormonal Therapies on Day 5 of Estrus on Plasma Progesterone Profile and Conception Rates in Repeat Breeding Dairy Cows

Effect of progesterone, human chorionic gonadotropin and progesterone + human chorionic gonadotropin treatment on conception rates in repeat breeder cows

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