Effects of gold salts and prednisolone on inflammatory cells. I. Phagocytic activity of macrophages and polymorphs in inflammatory exudates studied by a "skin-window" technique in rheumatoid and control patients.

Monocyte fc receptor function in rheumatoid arthritis. enhanced cell‐binding of igg induced by rheumatoid factors

“…Previous studies have shown that RA monocytes are activated, with elevated synthesis of complement components (23), prostaglandin El (24), increased phagocytic activity (25,26), and increased antibody-dependent cell-mddiated cytotoxity (ADCC) (27). Increased Fc receptor numbers in these monocytes could reflect such activation, possibly resulting from elevated levels of gamma interferon, seen in some patients with RA (4-7).…”

Sodium Aurothiomalate, Gold Keratinate, and Various Tetracyclines in Mycoplasma-Induced Arthritis of Rodents

“…Many other biological properties of gold have been described, including the stabilisation of lysosomal membranes (Weissman, 1966), the suppression of polymorphonuclear and macrophage phagocytosis and of macrophage migration (Vernon-Roberts, Jessop and Dor6, 1973 ;Jessop, Vernon-Roberts and Harris, 1973), immunosuppression (Lorber et al, 1974), C1 inactivation (Schultz et al, 1974), and immunoenhancement (Measel, 1975). These properties alone, or in combination, might be responsible for the antiarthritic effect of gold salts in mycoplasmal arthritis.…”

Inhibition of antigen- and mitogen-induced human lymphocyte proliferation by gold compounds.

“…In populations of human PBMI, the monocyte stibserves this function (18,21,22). Second, GST has been demonstrated to be actively internalized by mnacrophages in vivo (29)(30)(31) and to inhibit certain enzyme systems (32), as well as ftunctional capabilities of these cells (33). Thus, the action of gold on mitogen-and antigen-induced lymphocyte proliferationi might not result from inhibition of lymplhocyte responsiveness per se, but rather from interferenice with the requisite function of the monocyte popuilation in the initiation or stupport of stuch responses.…”

“…Second, GST has been shown to be actively endocytosed in vitro by guinea pig peritoneal macrophages with resulting inhibition of their lysosomal enzyme activity (32). Finally, the phagocytic activity of macrophages in experimentally induced inflammatory exudates has been found to be suppressed in patients with rheumatoid arthritis receiving gold therapy as compared to untreated rheumatoid patients (33).…”