Effects of glycyrrhizic acid supplementation during nonlinear resistance training on inflammatory markers and muscular damage indices in overweight young men

Tavvafian, Naemehsadat; Darabi, Hamid; Ahani, Anush; Naghizadeh, H; Hajiaghaee, Reza; Rahmati-Ahmadabad, Saleh; Azarbayjani, Mohammad Ali

doi:10.1016/j.obmed.2019.100178

Cited by 11 publications

(16 citation statements)

References 28 publications

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“…The higher the degree value, the more targets the compounds will interact with. Our previous study has shown that glycyrrhizic acid and curcumin were the major effective compounds of BMO which (Tavvafian et al, 2020). Feng et al (2013) found that glycyrrhizic acid could cause the inhibition of the RAGE/NF-κB pathway, thus having anti-apoptotic, anti-inflammatory, and antioxidative stress effects, which was demonstrated to have a protective effect on AGEs-induced endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, Glycyrrhizae Radix et Rhizoma has been widely reported to have anti-inflammatory and antioxidant effects, etc. (Feng et al, 2013;Tavvafian et al, 2020). However, the molecular mechanism of BMO has not been clarified.…”

Section: Discussionmentioning

confidence: 99%

“…Researches have shown that glycyrrhizic acid does well in anti-inflammatory and immunomodulatory effects. Naemehsadat T et al demonstrated that glycyrrhizic acid could significantly decrease serum TNF-α, IL-6, and IL-1β in overweight young men to decrease muscular damage ( Tavvafian et al, 2020 ). Feng et al (2013) found that glycyrrhizic acid could cause the inhibition of the RAGE/NF-κB pathway, thus having anti-apoptotic, anti-inflammatory, and antioxidative stress effects, which was demonstrated to have a protective effect on AGEs-induced endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

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Study on the Mechanism of Baimai Ointment in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking with Experimental Verification

et al. 2021

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Purpose: The external preparation of the Tibetan medicine formula, Baimai ointment (BMO), has great therapeutic effects on osteoarthritis (OA). However, its molecular mechanism remains almost elusive. Here, a comprehensive strategy combining network pharmacology and molecular docking with pharmacological experiments was adopted to reveal the molecular mechanism of BMO against OA.Methods: The traditional Chinese medicine for systems pharmacology (TCMSP) database and analysis platform, traditional Chinese medicine integrated database (TCMID), GeneCards database, and DisGeNET database were used to screen the active components and targets of BMO in treating OA. A component–target (C-T) network was built with the help of Cytoscape, and the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment through STRING. Autodock Tools which was used to dock the key components and key target proteins was analyzed. Animal experiments were performed to verify the key targets of BMO. Hematoxylin–eosin and toluidine blue staining were used to observe the pathology of joints. Protein expression was determined using enzyme-linked immunosorbent assay.Results: Bioactive compounds and targets of BMO and OA were screened. The network analysis revealed that 17-β-estradiol, curcumin, licochalone A, quercetin, and glycyrrhizic acid were the candidate key components, and IL6, tumor necrosis factor (TNF), MAPK1, VEGFA, CXCL8, and IL1B were the candidate key targets in treating OA. The KEGG indicated that the TNF signaling pathway, NF-κB signaling pathway, and HIF-1 signaling pathway were the potential pathways. Molecular docking implied a strong combination between key components and key targets. The pathology and animal experiments showed BMO had great effects on OA via regulating IL6, TNF, MAPK1, VEGFA, CXCL8, and IL1B targets. These findings were consistent with the results obtained from the network pharmacology approach.Conclusion: This study preliminarily illustrated the candidate key components, key targets, and potential pathways of BMO against OA. It also provided a promising method to study the Tibetan medicine formula or external preparations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Study on the Mechanism of Baimai Ointment in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking with Experimental Verification

et al. 2021

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“…Data pertaining to the study population, exercise program, and outcome measures (pre‐ and post‐study means and standard deviation of (CRP, IL‐6, and TNF‐α) were extracted for each intervention 12‐70 . Where more than one timepoint throughout the intervention was provided, the pre‐ and post‐intervention values were extracted, and other intra‐intervention values omitted (n = 2).…”

Section: Methodsmentioning

confidence: 99%

“…Thus, I 2 estimates of <25%, 50%, and 75% are considered to indicate low, moderate, and high heterogeneity, respectively. SMD between groups higher than 3 or lower than –3 standard deviations, or substantial decrease in the standard deviation, with no change in the average, were not included in the meta‐analyses (quantitative synthesis) due to implausible tabulated results (n = 1 CRP 42 ; n = 2 IL‐6 20,60 ; and n = 1 TNF‐ α 61 ).…”

Section: Methodsmentioning

confidence: 99%

Effect of resistance training on chronic inflammation: A systematic review and meta‐analysis

Rose

Mielke

Durr

et al. 2021

Translational Sports Med

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Objectives To determine the pooled effect of resistance training compared with a control, on chronic inflammation in adults through systematic review and meta‐analysis (osf.io/xastp). Methods Intervention trials that assessed resistance training versus control, on peripheral, chronic pro‐inflammatory markers [C‐reactive protein (CRP), interleukin (IL)‐6, and tumor necrosis factor (TNF)‐α] in adults were included, from four databases. Random‐effect meta‐analyses were conducted to calculate standardized mean differences (SMD) in post‐intervention values between groups. Meta‐regression explored the influence of age, chronic disease, body mass index, progressive resistance training (PRT), and intervention intensity, volume, duration, and “optimal prescription” on the pooled effect. Results Of 3,186 studies identified, 59 were included. Resistance training reduced CRP (SMD = −0.28; 95% CI = −0.46, −0.10), but not IL‐6 (SMD = −0.12; 95% CI = −0.31, 0.07) or TNF‐α (SMD = −0.07; 95% CI = −0.31, 0.16). Some heterogeneity was explained by interventions of lower intensity (<75% 1RM; 11.47%) or volume between 201 and 300 reps (6.14%). Conclusion Resistance training instigates small but significant reductions in CRP, but not IL‐6 or TNF‐α. Reductions in inflammation caused by resistance training may be influenced by intensity and volume, warranting further investigation. Resistance training should be implemented for chronic disease prevention or reduced progression, given pooled reductions in CRP.

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Exercise against SARS-CoV-2 (COVID-19): Does workout intensity matter? (A mini review of some indirect evidence related to obesity)

Rahmati-Ahmadabad

Hosseini

2020

Obesity Medicine

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Effects of glycyrrhizic acid supplementation during nonlinear resistance training on inflammatory markers and muscular damage indices in overweight young men

Cited by 11 publications

References 28 publications

Study on the Mechanism of Baimai Ointment in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking with Experimental Verification

Study on the Mechanism of Baimai Ointment in the Treatment of Osteoarthritis Based on Network Pharmacology and Molecular Docking with Experimental Verification

Effect of resistance training on chronic inflammation: A systematic review and meta‐analysis

Exercise against SARS-CoV-2 (COVID-19): Does workout intensity matter? (A mini review of some indirect evidence related to obesity)

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