Effects of Glycine max (L.) Merr. soy isoflavone vaginal gel on epithelium morphology and estrogen receptor expression in postmenopausal women: A 12-week, randomized, double-blind, placebo-controlled trial

Lima, Sônia Maria Rolim Rosa; Bernardo, Bianca Franco Augusto; Yamada, Silvia Saito; Reis, B.F.; Silva, Gustavo Maximiliano Dutra da; Galvão, Maria Antonieta Longo

doi:10.1016/j.maturitas.2014.04.007

Cited by 34 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lima et al conducted a study with 60 postmenopausal women, who were treated with either isoflavone 4% vaginal gel (1 g/day) or a placebo. They found that the isoflavone gel could decrease vaginal atrophy and dyspareunia and also increased the amounts of intermediate and superficial cells [24]. These results provide further support for our findings.…”

Section: Discussionsupporting

confidence: 89%

Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled trial

et al. 2016

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 89%

Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled trial

et al. 2016

View full text Add to dashboard Cite

“…The results of this study are mainly in line with those of the study performed by Lima et al . [ 16 ] who carried out an investigation to examine the effect of soybean vaginal gel on vaginal atrophy and reported that MVI had a significant improvement in the soybean group 12 weeks after the therapy ( P < 0.001).…”

Section: Discussionmentioning

confidence: 99%

“…In a study carried out by Lima et al .,[ 16 ] after investigating the effect of soybean vaginal cream for the treatment of vaginal atrophy, there was a significant decrease observed in vaginal acidity in both soybean and placebo groups ( P < 0.001).…”

Section: Discussionmentioning

confidence: 99%

“…Based on the results presented by Lima et al .,[ 16 ] there was a significant effect of applying soybean vaginal cream on vaginal dryness after a period of 12 weeks ( P < 0.001). In the soybean group, 70% of the participants reported severe vaginal dryness and 30% moderate dryness, while after 4 weeks of treatment, 66.7% reported moderate vaginal dryness, 23.3% mild vaginal dryness, and 10% lack of vaginal dryness, and after 12 weeks, 56% reported mild vaginal dryness, 40% lack of vaginal dryness, and 3.3% mild vaginal dryness.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Trigonella foenum (fenugreek) vaginal cream on vaginal atrophy in postmenopausal women

Mazalzadeh

Hekmat

Namjouyan

et al. 2020

J Family Med Prim Care

View full text Add to dashboard Cite

Background and Objective: Menopause forms one-third of women's lives. During this period, many women continue their sexual activities. One of the most prevalent postmenopausal complications is vaginal atrophy whose symptoms could have destructive effects on the life quality among postmenopausal women. Complications of using estrogen hormone to improve these symptoms are inevitable. One of the objectives of the present study is the assessment of the vaginal cream of Fenugreek on vaginal inflammation of atrophic vaginitis in postmenopausal women. Materials and Methods: For assessment of the effect of fenugreek vaginal cream among postmenopausal women who suffer from vaginal atrophy, the present study was carried out in the form of a double-blind clinical trial among sixty postmenopausal women, mainly who had been referred to Health Center 1 located in the east of Ahvaz in 2017. All participants of the present study who were diagnosed with vaginal atrophy were assigned into two groups of 30 randomly. One of these groups received placebo and the other one fenugreek 5% vaginal cream for a period of 8 weeks. Symptoms related to vaginal atrophy were investigated by means of a 4-degree scale (none, mild, moderate, and severe) and maturation vaginal index (MVI) through preparing the vaginal smears technique at baseline and a period of 8 weeks after cytology and intervention experiment. Finally, the process of analyzing statistical data, at a statistical significance level of 0.05, was carried out by means of SPSS Software. Results: The results of the present study demonstrated that the fenugreek vaginal cream treatment group experienced a significant improvement in vaginal atrophy symptoms compared to the onset of the study ( P < 0.001). Conclusion: Fenugreek vaginal cream was effective in treating vaginal atrophy; therefore, postmenopausal women are recommended to use this cream instead of synthetic estrogen to reduce the complications of this hormone.

show abstract

“…In a 12-week, double-blind placebo-controlled study of vaginally applied 4% soy isofl avone gel, improvements in vaginal atrophy symptoms, maturation values, and vaginal pH were found in 60 postmenopausal women. 38 Additional data on effi cacy and safety are needed before isofl avones should be considered as a treatment for GSM.…”

Section: Isofl Avonesmentioning

confidence: 99%

Genitourinary syndrome of menopause: Common problem, effective treatments

Phillips

Bachmann

2018

CCJM

View full text Add to dashboard Cite

show abstract

Effects of Glycine max (L.) Merr. soy isoflavone vaginal gel on epithelium morphology and estrogen receptor expression in postmenopausal women: A 12-week, randomized, double-blind, placebo-controlled trial

Cited by 34 publications

References 31 publications

Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled trial

Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled trial

Effect of Trigonella foenum (fenugreek) vaginal cream on vaginal atrophy in postmenopausal women

Genitourinary syndrome of menopause: Common problem, effective treatments

Contact Info

Product

Resources

About