Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled trial

Honarmandpour, Azam; Abedi, Parvin; Najar, Shahnaz; Namjoyan, Foroogh; Saki, Amal

doi:10.1016/j.maturitas.2015.11.005

Cited by 50 publications

(45 citation statements)

References 20 publications

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“…The Greene Questionnaire: This scale was developed by Greene in 1975 in Scotland, and its validity and reliability have been confirmed. 21) This questionnaire includes 21 items related to menopausal complications in five aspects: anxiety (items 1-6), depression (items 7-11), somatic (items 12-18), vasomotor dysfunction (items [19][20], and sexual dysfunction (items 21). Each symptom was scored by the subject.…”

Section: Measurement Instrumentsmentioning

confidence: 99%

“…[14][15][16][17] Vitex has numerous uses in traditional medicine, and primary studies have demonstrated its effectiveness in decreasing menopausal complications. [18][19][20] The fruit of this plant is administered as treatment for menopausal complaints. Currently, in European and American countries, the use of the Vitex fruit for its therapeutic effects on women with reproductive problems, premenstrual syndrome, infertility, and hyperprolactinemia is common.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study

et al. 2019

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Background: Menopausal symptoms have remarkable negative effects on women's quality of life, justifying the need to assess various therapeutic options. This research aimed to determine the effectiveness of Vitex agnus-castus extracts in alleviating menopausal symptoms in comparison with that of placebo. Methods: This study was a randomized controlled double-blind clinical trial with a study group of 52 women referred to a clinic in Kermanshah in 2017. The participants were randomly divided into two groups: Vitex group (26 subjects) and placebo group (26 subjects). Menopausal symptoms were assessed using the Greene Scale before and 8 weeks after the intervention. Results: After the intervention, the mean scores for total menopausal disorder, anxiety, and vasomotor dysfunction were significantly lower in the Vitex group than in the placebo group (P<0.05). The mean scores of the variables of somatic complications, depression, and sexual dysfunction did not show significant differences between the Vitex and placebo groups (P>0.05). Conclusion: Administration of Vitex agnus-castus extracts as a phytoestrogenic medicine can alleviate menopausal symptoms in women.

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Section: Measurement Instrumentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study

et al. 2019

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“…The vaginal pH significantly reduced after 8 weeks in the fennel group compared to the placebo group (100% versus 7.7%). The participants in the fennel group had a VMI of 65-100% after 8 weeks, while 40.7% of women in the placebo group had a VMI of 50-64% (27). The improvement of vaginal atrophy can be considered as a cause of the improvement of sexual function in postmenopausal women in this study.…”

mentioning

confidence: 56%

Efficacy of Combined Herbal Capsule on Sexual Function in Postmenopausal Women: A Triple-Blinded Randomized Controlled Trial

Eliasvandi

Khodaie

Mohammad‐Alizadeh‐Charandabi

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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Objectives: Considering the prevalence of sexual problems in postmenopausal women as well as complications of hormone therapy, the tendency to use complementary medicine has increased. The present study was conducted to evaluate the efficacy of combined herbal drug on the sexual function of postmenopausal women. Materials and Methods: The present triple-blinded randomized controlled trial was done on 64 Iranian women in 2017. The women were randomly allocated to 2 groups of intervention (combined herbal capsules users) and control (placebo users). Herbal capsules contained carnation, Anise, Anison, violets, Terminalia chebula, fresh green raisins, Senna leaves, Tangerine and Golqand. Participants in both groups took 2 capsules twice a day (before lunch and before dinner) for 4 weeks. The Female Sexual Function Index (FSFI) was filled out before the intervention and 4 weeks after the intervention. Results: No statistically significant difference was observed between the study groups in terms of socio-demographic properties, the total mean score of sexual function and its sub-domains before the intervention. Four weeks after the intervention, the total mean (SD) sexual function score was 26.99 (5.31) in the combined herbal capsule group and it was 18.35 (4.51) in the placebo group, so it was significantly higher in the combined herbal capsule group compared to the placebo group (adjusted mean difference=8.70; 95% CI=6.58-10.82). Moreover, there was a significant difference in the mean score of desire, arousal, lubrication, orgasm, satisfaction, and pain subscales between study groups after the intervention. Conclusions: The results of the study show that taking combined herbal capsules improved sexual function in postmenopausal women. However, further studies are necessary to decide on its use as an alternative medication for the improvement of sexual function.

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“…Eine weitere, ebenfalls iranische Studie, untersuchte 2015 eine Fenchel-Vaginalcreme bei Trockenheitssymptomen. Nach acht Wochen lokaler Anwendung einer speziell für diese Studie hergestellten Creme mit 5 % Fenchelextrakt hatten sich die Be-schwerden signifikant verringert, und die Schleimhaut hatte sich regeneriert [5].…”

Section: Option Bei Dysmenorrhoe Pms Und Wechseljahrenunclassified

Würziger Krampflöser aus der Antike

Stumpf¹

2019

Deutsche Heilpraktiker-Zeitschrift

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Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled trial

Cited by 50 publications

References 20 publications

Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study

Comparison of Vitex agnus-castus Extracts with Placebo in Reducing Menopausal Symptoms: A Randomized Double-Blind Study

Efficacy of Combined Herbal Capsule on Sexual Function in Postmenopausal Women: A Triple-Blinded Randomized Controlled Trial

Würziger Krampflöser aus der Antike

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