Effects of Glucan and Vitamin D Supplementation on Obesity and Lipid Metabolism in Diabetic Retinopathy

Abstract

Background:Diabetes mellitus is a chronic disease manifested by an increase of blood glucose.Objective:To evaluate the effects of glucan and vitamin D supplementation in patients with diabetic retinopathy.Method:We evaluated the effects of 3-month supplementation with glucan and vitamin D in 54 patients with diabetic retinopathy. We measured levels of vitamin D, cholesterol, HDL cholesterol, and triglycerides.Results:The supplementation strongly decreased the cholesterol levels and improved the levels of HDL cholesterol. In addition, vitamin D levels were strongly improved, but still not at optimal values.Conclusion:From our data, we concluded that glucan and vitamin D supplementation strongly influence lipid metabolism and have positive effects on human health.

Diabetic Retinopathy: Changes in Levels of Orosomucoids in Patients Supplemented with Beta Glucan and Vitamin D

“…Lately, an association between vitamin D deficit and risk of DM2 development is being discussed in the literature (Lu et al, 2018). Our findings show that vitamin D supplementation helps to improve several clinical manifestation of DM2 and its complications (Zavorkova et al, 2018;Christiansen et al, 2010). Risk of DR development in overweight or obese individuals is well documented (Zhou et al, 2017) and further confirmed by our findings.…”

“…This study is a follow-up of previous observation showing effects of glucan on lipid metabolism and obesity in patients with DAR (Richter et al, 2018a;2018b;Zavorkova et al, 2018). In this study we report significant decrease of ORM levels after the end of the three-month treatment.…”

“…In addition, glucan can significantly decrease food consumption, regulate glycemic index of food and positively affect glucose metabolism in patients with DM2 (Straczkowski et al, 2018;Bashir and Choi, 2017;McRae, 2018). In our group of patients with DM2 and DR we demonstrated significant changes of lipid metabolism caused by improvements of vitamin D levels and after glucan application (Zavorkova et al, 2018). In the current study we follow-up the previous work and focus on evaluation of ORM levels after glucan and vitamin D supplementation.…”

“…Risk of DM development increases with weight gain, together with an increase of clinical problems related to metabolic syndrome (Richter et al, 2018a;2018b;Zhou et al, 2017). Authors emphasize that for evaluation of this relation, it is better to replace the BMI criterium by other measurements (such as WHR) (Zhou et al, 2017;Zavorkova et al, 2018). Incidence of additional comorbidities connected with high weight is also related to significant changes of nonspecific and specific immune responses.…”

“…Several studies demonstrated associations between levels of vitamin D and incerased risk of development of DM2 (Lu et al, 2018;Spiro and Buttriss, 2014). Vitamin D supplementation, resulting in changes of its levels, results in significant decrease of risk of DM2 (Zavorkova et al, 2018;Luo et al, 2015). Numerous studies found deficits in vitamin D levels not only in European countries, but worldwide (Tessari and Lante, 2017).…”