Effects of glistenings in intraocular lenses

Mooren, Marrie Van der; Franssen, Luuk; Piers, Patricia

doi:10.1364/boe.4.001294

Cited by 38 publications

(29 citation statements)

References 27 publications

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“…36 Contrast sensitivity losses of 14% to 20%, as induced by low amounts of retinal stray light, have been predicted. 9 This demonstrates the clinical relevance of small elevated levels of retinal stray light. The retinal stray light effect on CS was largest with a glare source present at 2.58, causing a veiling luminance deteriorating the contrast of the image on the retina.…”

Section: Discussionmentioning

confidence: 87%

“…The stray light effects induced by glistenings are predominantly distributed around two retinal peaks located at an angle of 2.58 and 158. 9 This means that the standard C-quant is not the most suitable instrument to detect the effects of glistenings, as it operates with a glare source located at an average angle of 78. The extended C-quant used in this study, which performs stray light measurements at an average angle of 2.58, is therefore a better instrument for measuring these effects.…”

Section: Discussionmentioning

confidence: 99%

“…Forward stray light levels can be as much as 300 times larger than that of the measured backward scatter due to the fact that glistenings induce Mie scatter. 9 The double-pass technique has the potential to estimate the forward scatter. However, the currently available double-pass method provides a scatter index that is defined only within the central angular range of 0.38, 30 and was therefore not suitable for this study.…”

Section: Discussionmentioning

confidence: 99%

“…8 Furthermore, the stray light behavior of micro-vacuoles or glistenings has been described in the past for four different types of IOLs. 9 However, retinal stray light is currently not routinely measured in clinical practice as a way to diagnose cataract or glistenings; the opacification of the crystalline lens or the micro-vacuoles in the optic body are routinely assessed only in a slit-lamp exam. This exam subjectively illustrates the effect of backward scattered light from the opacities, while it is the forward light scattering distributed over the retina that determines the visual impairment.…”

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confidence: 99%

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Degradation of Visual Performance With Increasing Levels of Retinal Stray Light

Mooren

Rosén

Franssen

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To quantify the effect of induced stray light on halo size, luminance threshold, and contrast sensitivity. METHODS.Retinal stray light was induced in five healthy subjects using different photographic filters. The stray light induced ranged from levels observed in intraocular lenses (IOLs) with glistenings (low) to cataract level (high). The visual impact was measured for halo size, luminance detection threshold, and contrast sensitivity with and without a glare source.RESULTS. The amount of retinal stray light induced by the different filters was similar when measured using the psychophysical method and the optical bench method. Low amounts of induced stray light cause the halo size to increase by 21%, the luminance detection threshold to increase by 156%, and contrast sensitivity to decrease by 10% to 21% dependent on spatial frequency and presence of a glare source. The visual impact percentages for high amounts of induced stray light were, respectively, 76%, 2130%, and 30% to 49%. In the presence of a glare source, contrast sensitivity losses were larger and shifted to lower spatial frequencies.CONCLUSIONS. Low levels of retinal stray light can cause significant increases in halo sizes, elevations in luminance detection thresholds, and reductions in contrast sensitivity whether or not a glare source is present.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Degradation of Visual Performance With Increasing Levels of Retinal Stray Light

Mooren

Rosén

Franssen

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…Straylight from larger particles (e.g. glistenings, surface deposits) has been studied [3][4][5][6]. Submicron particles have also been found in IOLs (i.e.…”

Section: Introductionmentioning

confidence: 99%

Validation of a spectral light scattering method to differentiate large from small particles in intraocular lenses

Łabuz

Papadatou

Vargas-Martı́n

et al. 2017

Biomed. Opt. Express

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Abstract:A psychophysical approach has been designed to measure straylight from intraocular lenses (IOLs) in vitro. This approach uses a clinical straylight meter (C-Quant) and an observer's eye as optical detector. Based on this, we introduced a method for study of straylight-wavelength dependency for IOLs. This dependency can be used to distinguish between 2 types of scattering particles (small and large) as defined by Mie theory. Validation was performed using a turbidity standard and scattering filters. Several IOLs were analyzed to identify potential scattering sources. Large particles were found to predominate in scattering from the studied lenses. This was confirmed by straylight-angular dependency found in these IOLs.

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Identification-Tagging of Methacrylate-Based Intraocular Implants Using Sequence Defined Polyurethane Barcodes

et al. 2016

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International audienceSequence-coded polyurethanes were tested as anti-counterfeiting tags for the labelling of methacrylate-based intraocular implants. These sequence-defined oligomers were prepared by solid-phase iterative chemistry using two comonomers allowing formation of a controlled 0/1 binary sequence. Tags with different sequences and chain-lengths were synthesized and tested for lenses labeling. Two main methods were investigated for incorporating the tags in the intraocular implants. In a first approach, they were included in situ during the free-radical copolymerization of 2-ethoxyethyl methacrylate and ethylene glycol dimethylacrylate. In another strategy, premade lenses were swollen in a THF solution containing the polyurethane tags and dried. Both approaches allowed successful incorporation of the polyurethane labels in the methacrylate networks. In order to demonstrate this, the tags were extracted from the lenses using a solvent swelling protocol and analyzed by electrospray mass spectrometry. In all cases, the labels were found and their coded sequences could be identified by tandem mass spectrometry sequencing. These results indicate that sequence-coded polyurethane tags represent a valid option for the labeling of implants. Importantly, it was shown in this work that the use of small weight fractions of polyurethane tag (i.e. 0.1-0.4 wt%) do not alter significantly the biocompatibility and transparency properties of the intraocular lenses

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Effects of glistenings in intraocular lenses

Cited by 38 publications

References 27 publications

Degradation of Visual Performance With Increasing Levels of Retinal Stray Light

Degradation of Visual Performance With Increasing Levels of Retinal Stray Light

Validation of a spectral light scattering method to differentiate large from small particles in intraocular lenses

Identification-Tagging of Methacrylate-Based Intraocular Implants Using Sequence Defined Polyurethane Barcodes

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