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The compensation comparison method for measuring retinal straylight is suited for clinical use to diagnose patients with complaints caused by large angle light scattering in the eye such as early cataract.

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The BPM 2 filter is a good early-cataract-simulating filter. Stacking such filters is a good way to increase the cataract density. A drawback is that the BPM 2 filter has a transmission of 66% so stacking filters reduces the overall transmission significantly.

The point spread function or PSF of the human eye encompasses hugely different domains: a small-angle, high-intensity domain, called the 'PSF core', and a large-angle, low-intensity domain, usually referred to as 'straylight'. The first domain can be assessed by available double-pass or other optical techniques. For the second domain psychophysical techniques have been developed, in particular the Compensation Comparison or CC technique, recently made available for clinical application in the C-Quant instrument. We address the question of whether the psychophysical technique gives measures of straylight that are compatible with those made by optical methods. With a small adaptation the CC method can be used to assess straylight from physical light scattering samples, instead of straylight in the eye, using the same psychophysics, but without interference from the ocular straylight. The light scattered by each of seven light-scattering samples, encompassing the range of straylight values observed in human eyes, was measured by two optical methods and by the psychophysical technique. The results showed that the optical and psychophysical measurements for the seven samples were almost identical.

The compensation comparison (CC) method is a psychophysical technique to measure retinal stray light. It uses a two alternative forced choice (2AFC) measurement paradigm. The 25 binary (0 and 1) responses resulting from the 2AFC test are analyzed using maximum likelihood estimates. The likelihood function is used to give two quantities: the most likely stray-light level of the eye under investigation, and the accuracy of this estimate [called expected standard deviation (ESD)]. The CC method is used in 2422 subjects of the GLARE study. Each eye is tested twice to allow analysis of measurement repeatability. Furthermore, the large amount of responses is used to evaluate the shape of the psychometric function, for which a mathematical model is used. The shape of the psychometric function found by averaging the 0 and 1 responses fit well to the model function. Data sorted according to ESD show differences in the shape of the psychometric function between good and bad observers. These different shapes for the psychometric function are used to reanalyze the data, but the stray-light results remain virtually identical. ESD proves to be an efficient tool to detect unreliable measurements. In clinical practice, ESD may be used to decide whether to repeat a measurement.

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