Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats

Yang, Qiyu; Lai, Xiaodan; Ouyang, Jing; Yang, Jiadan

doi:10.1016/j.tox.2018.08.010

Cited by 50 publications

(21 citation statements)

References 56 publications

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“…Rg1, Rb1, and Rg3 have been linked with an improvement in mitochondrial function [48,49]. While it is not easy to find a clear structure-activity relationship of ginsenosides against muscle function, interestingly Rb1 and Rg3, which are both from the protopanaxadiol group of ginsenosides (Supplementary Figure S1), displayed beneficial effects toward muscle function [50,51]. These observations suggest that specific ginsenosides of red ginseng can contribute to the improvement in exercise endurance and muscle function.…”

Section: Discussionmentioning

confidence: 95%

Red Ginseng Improves Exercise Endurance by Promoting Mitochondrial Biogenesis and Myoblast Differentiation

Shin

Choi

et al. 2020

Molecules

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Red ginseng has been reported to elicit various therapeutic effects relevant to cancer, diabetes, neurodegenerative diseases, and inflammatory diseases. However, the effect of red ginseng on exercise endurance and skeletal muscle function remains unclear. Herein, we sought to investigate whether red ginseng could affect exercise endurance and examined its molecular mechanism. Mice were fed with red ginseng extract (RG) and undertook swimming exercises to determine the time to exhaustion. Animals fed with RG had significantly longer swimming endurance. RG treatment was also observed to enhance ATP production levels in myoblasts. RG increased mRNA expressions of mitochondrial biogenesis regulators, NRF-1, TFAM, and PGC-1α, which was accompanied by an elevation in mitochondrial DNA, suggesting an enhancement in mitochondrial energy-generating capacity. Importantly, RG treatment induced phosphorylation of p38 and AMPK and upregulated PGC1α expression in both myoblasts and in vivo muscle tissue. In addition, RG treatment also stimulated C2C12 myogenic differentiation. Our findings show that red ginseng improves exercise endurance, suggesting that it may have applications in supporting skeletal muscle function and exercise performance.

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Section: Discussionmentioning

confidence: 95%

Red Ginseng Improves Exercise Endurance by Promoting Mitochondrial Biogenesis and Myoblast Differentiation

Shin

Choi

et al. 2020

Molecules

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“…The ginsenosides Rb1, Rg1, Rc, Rb2, and Re were abundant in the red ginseng extract used in this study and have been reported to prevent cellular senescence induced by H 2 O 2 exposure in astrocyte [64]. In addition, ginsenoside Rc was reported to be the major component of Panax ginseng that prolongs the lifespan of C. elegans [17], and ginsenoside Rg3 can activate Sirtuin deacetylase activity in rat [65]. Further studies to examine the role of specific ginsenosides on lifespan extension will help to elucidate the major components of Panax ginseng that are active in extending lifespan and to develop novel DR mimetic.…”

Section: Discussionmentioning

confidence: 99%

Extension of Drosophila lifespan by Korean red ginseng through a mechanism dependent on dSir2 and insulin/IGF-1 signaling

Lee

et al. 2019

Aging

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Many studies have indicated that Korean red ginseng (KRG) has anti-inflammatory and anti-oxidative effects, thereby inducing many health benefits in humans. Studies into the longevity effects of KRG are limited and have provided contradictory results, and the molecular mechanism of lifespan extension by KRG is not elucidated yet. Herein, the longevity effect of KRG was investigated in Drosophila melanogaster by feeding KRG extracts, and the molecular mechanism of lifespan extension was elucidated by using longevity-related mutant flies. KRG extended the lifespan of Drosophila when administrated at 10 and 25 μg/mL, and the longevity benefit of KRG was not due to reduced feeding, reproduction, and/or climbing ability in fruit flies, indicating that the longevity benefit of KRG is a direct effect of KRG, not of a secondary artifact. Diet supplementation with KRG increased the lifespan of flies on a full-fed diet but not of those on a restricted diet, and the longevity effect of KRG was diminished by the mutation of dSir2, a deacetylase known to mediate the benefits of dietary restriction. Similarly, the longevity effect of KRG was mediated by the reduction of insulin/IGF-1 signaling. In conclusion, KRG extends the lifespan of Drosophila through Sir2 and insulin/IGF-1 signaling and has potential as an anti-aging dietary-restriction mimetic and prolongevity supplement.

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“…Ginsenoside Rg3, another active compound of P. ginseng , was considered to have the fatigue resistance effect on POFS rats [ 48 ]. Rg3 can also increase journey and feeding frequency.…”

Section: Anti-fatigue Effect Of P Ginseng On Animal Modelsmentioning

confidence: 99%

Recent Advances in Panax ginseng C.A. Meyer as a Herb for Anti-Fatigue: An Effects and Mechanisms Review

Liu

Wang

2021

Foods

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As an ancient Chinese herbal medicine, Panax ginseng C.A. Meyer (P. ginseng) has been used both as food and medicine for nutrient supplements and treatment of human diseases in China for years. Fatigue, as a complex and multi-cause symptom, harms life from all sides. Millions worldwide suffer from fatigue, mainly caused by physical labor, mental stress, and chronic diseases. Multiple medicines, especially P. ginseng, were used for many patients or sub-healthy people who suffer from fatigue as a treatment or healthcare product. This review covers the extract and major components of P. ginseng with the function of anti-fatigue and summarizes the anti-fatigue effect of P. ginseng for different types of fatigue in animal models and clinical studies. In addition, the anti-fatigue mechanism of P. ginseng associated with enhancing energy metabolism, antioxidant and anti-inflammatory activity is discussed.

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Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats

Cited by 50 publications

References 56 publications

Red Ginseng Improves Exercise Endurance by Promoting Mitochondrial Biogenesis and Myoblast Differentiation

Red Ginseng Improves Exercise Endurance by Promoting Mitochondrial Biogenesis and Myoblast Differentiation

Extension of Drosophila lifespan by Korean red ginseng through a mechanism dependent on dSir2 and insulin/IGF-1 signaling

Recent Advances in Panax ginseng C.A. Meyer as a Herb for Anti-Fatigue: An Effects and Mechanisms Review

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