Effects of ginsenoside Rb1 at low doses on histamine, substance P, and monocyte chemoattractant protein 1 in the burn wound areas during the process of acute burn wound repair

Kawahira, Kazuhiro; Sumiyoshi, Maho; Sakanaka, Masahiro; Kimura, Yoshiyuki

doi:10.1016/j.jep.2008.01.032

Cited by 15 publications

(11 citation statements)

References 34 publications

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“…Its effective components Ginsenoside Rg1, Re, and Rb1, modulate angiogenesis, with a potential to be developed as angiotherapeutic agents (Cheung et al, 2011; Kawahira et al, 2008; Kimura et al, 2006; Leung et al, 2011; Yue et al, 2005). Rg1 stimulates hypoxia-induciblefactor-1α (HIF-1α) and induces VEGF expression (Cheung et al, 2011; Leung et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells

Chen

Zhang

et al. 2016

Journal of Ethnopharmacology

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Ethnopharmacological relevance Lymphatic system plays an important role in maintaining the fluid homeostasis and normal immune responses, anatomic or functional obstruction of which leads to lymphedema, and treatments for therapeutic lymphangiogenesis are efficiency for secondary lymphedema. Total saponins of panaxnotoginseng (PNS) are a mixture isolated from Panaxnotoginseng (Burkill) F.H. Chen, which has been used as traditional Chinese medicine in China for treatment of cardio- and cerebro-vascular diseases. The aim of this study was to determine the effect and mechanism of PNS on lymphangiogenesis. Methods The Tg (fli1:egfp; gata1:dsred) transgenic zebrafish embryos were treated with different concentrations of PNS (10, 50, 100μM) for 48 hours with or without the 6 hours pretreatment of the 30μM Vascular endothelial growth factors receptor (VEGFR)-3 kinase inhibitor, followed with morphological observation and lympangiogenesis of thoracic duct assessment. The effect of PNS on cell viability, migration, tube formation and Vascular endothelial growth factors (VEGF)-C mRNA and protein expression of lymphatic endothelial cells (LECs) were determined. The role of phosphatidylinositol-3 (PI-3)-kinase (PI3K), extracellular signal-regulated kinase (ERK)1/2 pathways, c-Jun N-terminal kinase (JNK) and P38 mitogen activated protein kinases (MAPK) signaling in PNS-induced VEGF-C expression of LECs by using pharmacological agents to block each signal. Results PNS promotes lymphangiogenesis of thoracic duct in zebrafish with or without VEGFR3 Kinase inhibitor pre-impairment. PNS promotes proliferation, migration and tube formation of LECs. The tube formation induced by PNS could be blocked by VEGFR3 Kinase inhibitor. PNS induce VEGF-C expression of LEC, which could be blocked by ERK1/2, PI3K and P38MAPK signaling inhibitors. Conclusion PNS activates lymphangiogenesis both in vivo and in vitro by up-regulating VEGF-C expression and activation of ERK1/2, PI3K and P38MAPK signaling. These findings provide a novel insight into the role of PNS in lymphangiogenesis and suggest that it might be an attractive and suitable therapeutic agent for treating secondary lymphedema or other lymphatic system impairment related disease.

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Section: Discussionmentioning

confidence: 99%

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells

Chen

Zhang

et al. 2016

Journal of Ethnopharmacology

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“…GRb1 and PF are bioactive substances of traditional Chinese medicine and widely used to treat skin diseases based on their anti-inflammatory activities [22,23]. The aims of the present study are to investigate the anti-inflammatory effects of GRb1 and PF on keratinocytes and the possible mechanisms.…”

Section: Discussionmentioning

confidence: 98%

Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT

Jin

Qiu

Ding

et al. 2010

International Immunopharmacology

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“…Furthermore, our group has confirmed that compound K induces HA expression by activating Src/ERK and Akt signaling pathways in HaCaT cells (unpublished data). However, in comparison to the number of studies on other mechanisms of ginsenosides such as for cancer and obesity [27,29,38,41], research on the antiaging effects in skin remains relatively sparse.…”

Section: Discussionmentioning

confidence: 99%

“…Wound healing promotion is a well-known physiological property of Rb1, and acceleration of the wound healing process occurs via the modulation of various cellular signaling factors such as monocyte chemoattractant protein-1 and hypoxia-inducible factor-1a [27,37]. In 2006, Sakanaka's group demonstrated the burn wound healing action of Rb1 using in vivo and in vitro models, and suggested that the underlying mechanism of Rb1 relies on the induction of vascular endothelial growth factor (VEGF) and interleukin-1b expression.…”

Section: Biological Activitiesmentioning

confidence: 99%

Ginsenosides and their metabolites: a review of their pharmacological activities in the skin

et al. 2015

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Ginsenosides are representative pharmaceutical compounds found in various forms in Panax ginseng, a traditional medicinal plant. They are converted to their metabolites Rg2, Rg3, compound K, and others by human intestinal microflora following ingestion. Numerous studies have demonstrated beneficial effects of ginsenosides against aberrant molecular processes responsible for cancer, metabolic diseases and neurodegenerative diseases. Recently, antiaging effects of ginsenosides in human skin have been reported from clinical trial and in vitro model data. Ginsenosides have hence been proposed as promising natural cosmeceutical agents. In this review, we will critically review the known biological effects of several ginsenosides (Rb1, Rg3, Rd and compound K), such as anti-inflammatory and anticancer activities, which arise from the modulation of diverse molecular pathways. The application potential of ginsenosides as cosmeceutical ingredients will also be reviewed.

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Effects of ginsenoside Rb1 at low doses on histamine, substance P, and monocyte chemoattractant protein 1 in the burn wound areas during the process of acute burn wound repair

Cited by 15 publications

References 34 publications

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells

Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT

Ginsenosides and their metabolites: a review of their pharmacological activities in the skin

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