Effects of ginkgo biloba extract on an experimental model of epilepsy

Pilija, Vladimir; Ivetić-Petrović, Vesna R.; Mihalj, Marija; Draganić-Gajić, Saveta; Popović, Mira

doi:10.2298/mpns0412541p

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…Therefore, the possibilities of overdosage or interactions with other medications cannot be excluded. However, Ginkgo biloba extracts have been reported to have a proconvulsive activity on chinchilla rabbits [25], and it should also be mentioned that the action of GABAergic antiepileptica was negatively influenced, when seizures were induced in mice by various toxins [26]. Thus, the question arises whether the occurrence of seizures really could be due to the presence of ginkgotoxin when Ginkgo remedies are ingested, at least by predisposed patients.…”

Section: Discussionmentioning

confidence: 99%

The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba

Kästner

Hallmen²,

Wiese³

et al. 2007

The FEBS Journal

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Ginkgotoxin (4′‐O‐methylpyridoxine) occurring in the seeds and leaves of Ginkgo biloba, is an antivitamin structurally related to vitamin B6. Ingestion of ginkgotoxin triggers epileptic convulsions and other neuronal symptoms. Here we report on studies on the impact of B6 antivitamins including ginkgotoxin on recombinant homogeneous human pyridoxal kinase (EC 2.7.1.35). It is shown that ginkgotoxin serves as an alternate substrate for this enzyme with a lower Km value than pyridoxal, pyridoxamine or pyridoxine. Thus, the presence of ginkgotoxin leads to temporarily reduced pyridoxal phosphate formation in vitro and possibly also in vivo. Our observations are discussed in light of Ginkgo medications used as nootropics.

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Section: Discussionmentioning

confidence: 99%

The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba

Kästner

Hallmen²,

Wiese³

et al. 2007

The FEBS Journal

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“…Gingko, an extract from the leaves and seeds of the plant G. biloba L. has been used in the treatment of Alzheimer's (Kanowski et al, 1996;Oken et al, 1998) and premenstrual syndrome (Tamborini and Taurelle, 1993). It is reported to be pro-convulsive in animal models (Pilija et al, 2004) and initiates seizures in children (Fessenden et al, 2001). Gingko has been considered relatively safe (Hashiguchi et al, 2015), however caution should be used during lactation, as it partitions into breast-milk (Romaszko et al, 2014).…”

Section: Herbal-drug Interactions Epilepsy In Pregnancy and Hm Usementioning

confidence: 99%

Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know

et al. 2020

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About 80% of the consumers worldwide use herbal medicine (HMs) or other natural products. The percentage may vary significantly (7%-55%) among pregnant women, depending upon social status, ethnicity, and cultural traditions. This manuscript discusses the most common HMs used by pregnant women, and the potential interactions of HMs with conventional drugs in some medical conditions that occur during pregnancy (e.g., hypertension, asthma, epilepsy). It also includes an examination of the characteristics of pregnant HM consumers, the primary conditions for which HMs are taken, and a discussion related to the potential toxicity of HMs taken during pregnancy. Many cultures have used HMs in pregnancy to improve wellbeing of the mother and/or baby, or to help decrease nausea and vomiting, treat infection, ease gastrointestinal problems, prepare for labor, induce labor, or ease labor pains. One of the reasons why pregnant women use HMs is an assumption that HMs are safer than conventional medicine. However, for pregnant women with pre-existing conditions like epilepsy and asthma, supplementation of conventional treatment with HMs may further complicate their care. The use of HMs is frequently not reported to healthcare professionals. Providers are often not questioning HM use, despite little being known about the HM safety and HM-drug interactions during pregnancy. This lack of knowledge on potential toxicity and the ability to interact with conventional treatments may impact both mother and fetus. There is a need for education of women and their healthcare professionals to move away from the idea of HMs not being harmful. Healthcare professionals need to question women on whether they use any HMs or natural products during pregnancy, especially when conventional treatment is less efficient and/or adverse events have occurred as herbaldrug interactions could be the reason for these observations. Additionally, more preclinical and clinical studies are needed to evaluate HM efficacy and toxicity.

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“…Ginkgo biloba, Echinacea purpurea i Serenoa repens inhibišu aktivnost citohroma P 450, 3A4, 2D6 i 2D9 i utiču na metabolizam lekova [28]. Ginkgo biloba ima prokonvulzivno dejstvo što dovodi do češćih epileptogenih pražnjenja kod pacijenata koji dobijaju preparate na bazi ekstrakta Ginkgo bilobe pa sa njihovom primenom treba biti obazriv kod pacijenata sa epilepsijom [29].…”

Section: Diskusijaunclassified

Knowledge, attitudes and use of dietary supplement among students of the University of Nis (Serbia)

Miljković

Stojiljković²,

Radulović³

2013

Med pregl

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Effects of ginkgo biloba extract on an experimental model of epilepsy

Abstract: According to the results obtained in this research, we can conclude that ginkgo biloba extracts have a proconvulsive activity.

Cited by 4 publications

References 3 publications

The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba

The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba

Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know

Knowledge, attitudes and use of dietary supplement among students of the University of Nis (Serbia)

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