Effects of ghrelin on growth and cardiac function in infants with congenital heart disease

Kitamura, Toshiya; Shimizu, Toshiaki; Ohkawa, Natsuki; Oda, Hisayuki; Ohtsuki, Masahiro; Kishiro, Masahiko

doi:10.1111/j.1442-200x.2009.02966.x

Cited by 10 publications

(11 citation statements)

References 24 publications

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“…Non‐CHD adults with HF reportedly have much lower ghrelin levels than those without HF . Moreover, plasma ghrelin levels are significantly high in children with CHD . Elevated ghrelin levels in these children might be related to malnutrition, growth retardation, and chronic shunt‐induced hypoxemia, wherein increased ghrelin might be a compensatory mechanism .…”

Section: Discussionmentioning

confidence: 99%

“…24,29 Moreover, plasma ghrelin levels are significantly high in children with CHD. [8][9][10][11][12][13] Elevated ghrelin levels in these children might be related to malnutrition, growth retardation, and chronic shunt-induced hypoxemia, wherein increased ghrelin might be a compensatory mechanism. [8][9][10][11][12][13] In contrast, the mechanism underlying low ghrelin levels in adult patients with Fontan circulation and those with cyanosis is likely distinct.…”

Section: Ghrelin and Heart Failurementioning

confidence: 99%

“…Ghrelin and leptin are important appetite‐related hormones that control appetite. Reportedly, plasma ghrelin levels are significantly high in infants and children with CHD . An elevated ghrelin level, which has a favorable effect on growth, might be a compensatory mechanism for malnutrition and growth retardation in these patients .…”

Section: Introductionmentioning

confidence: 98%

“…Reportedly, plasma ghrelin levels are significantly high in infants and children with CHD. [8][9][10][11][12][13] An elevated ghrelin level, which has a favorable effect on growth, might be a compensatory mechanism for malnutrition and growth retardation in these patients. [8][9][10][11] Moreover, promising results with several ghrelin agonists have already been reported in animal models of HF-related body wasting.…”

Section: Introductionmentioning

confidence: 99%

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Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Shiina

Murakami

Matsumoto

et al. 2017

Congenital Heart Disease

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Objectives: To assess body composition and relationships among body composition, appetiterelated hormones, adipocytokines, and heart failure (HF) in adult patients with congenital heart disease (CHD).Patients: This prospective study enrolled 46 consecutive adult patients with CHD and 12 agematched healthy controls. The patients and control subjects were divided into four groups: 13 patients with Fontan circulation (group A), 16 patients with cyanosis (group B), 17 patients who previously underwent biventricular repair (group C), and 12 age-matched healthy controls.Design: Body composition was measured using InBody730, and levels of appetite-related hormones (ghrelin and leptin) and adipocytokines (leptin, interleukin-6, and tumor necrosis factor-a) were determined. Relationships of these measurements between severe HF, defined as New York Heart Association functional class III-IV and/or recent repeated unscheduled hospitalizations due to HF, were examined using univariate logistic analysis.Results: Mean patient age was 32.1 6 7.4 years. The skeletal muscle mass was significantly decreased in groups A and B compared with that in controls. Interestingly, ghrelin levels in groups A and B were also significantly lower than those in controls. Univariate logistic analysis revealed that ghrelin level, percent body fat, and pulse oximetric oxygen saturation were significantly associated with severe HF. Conclusions:Patients with Fontan circulation and those with cyanosis might be at a risk of sarcopenia. Despite the decreased skeletal muscle mass and increased body fat, ghrelin levels in these patients were decreased. These changes might have a negative impact on HF in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Ghrelin and Heart Failurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Shiina

Murakami

Matsumoto

et al. 2017

Congenital Heart Disease

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“…Ghrelin is a new growth hormone‐releasing peptide that regulates appetite as well as metabolism, resulting in a positive energy balance by driving food intake and triggering adiposity, and thereby affecting growth of the body . Ghrelin plays a role in cardiac function and in compensatory myocardial hypertrophy via vasodilatory activity and assimilation of proteins, as well as sympathetic nerve suppression . Ghrelin has been shown to control bodyweight gain and growth development via its adipose‐storing, growth hormone secretagogue and orexigenic activities .…”

Section: Discussionmentioning

confidence: 99%

Elevated serum ghrelin, tumor necrosis factor‐α and interleukin‐6 in congenital heart disease

Wang

Fang

Wang

et al. 2016

Pediatrics International

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Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol

Wang

et al. 2010

Journal of Peptide Science

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To explore the effects of ghrelin on disturbed myocardial energy metabolism during chronic heart failure (CHF). Rats were subcutaneously injected with isoproterenol (ISO) for 10 days with or without ghrelin for another 10 days. Enzyme immunoassay was to measure ghrelin concentrations. Compared with the control group, ISO-treated rats showed suppressed cardiac function with high ghrelin/GHS-R expressions. These rats also showed the decreases in food consumption and weight. The decreased levels of plasma glucose and myocardial glucogen, but the high lactate in blood and myocardium showed myocardial metabolic disturbance. Compared with the group given ISO alone, the rats with ghrelin (20 and 100 microg/kg/day) improved cardiac dysfunction and increased food intake by 13.5 and 14.2% (both P < 0.01), and rate of weight gain by 95% (P < 0.05) and 1.71-fold (P < 0.01), respectively. The plasma glucose were increased by 49.7 and 50.8% (both P < 0.01), and myocardial glucogen, by 40.5 and 51.7% (both P < 0.01), but blood lactate decreased by 1.56- and 1.96-fold (both P < 0.01), and myocardial lactate by 32.1 and 48.7% (both P < 0.05), respectively. Their MCT1 mRNA and protein expressions increased. The myocardial ghrelin/GHS-R pathway can be upregulated during CHF. The ghrelin can attenuate cardiac dysfunction and energy metabolic disturbance in CHF rats.

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Effects of ghrelin on growth and cardiac function in infants with congenital heart disease

Abstract: A-Ghr is involved in cardiac function and has little effect on their physique in infants with CHD.

Cited by 10 publications

References 24 publications

Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Body composition, appetite-related hormones, adipocytokines, and heart failure in adult patients with congenital heart disease: A preliminary study

Elevated serum ghrelin, tumor necrosis factor‐α and interleukin‐6 in congenital heart disease

Ghrelin improves disturbed myocardial energy metabolism in rats with heart failure induced by isoproterenol

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