Effects of ghrelin on gastric distension sensitive neurons and gastric motility in the lateral septum and arcuate nucleus regulation

Abstract

It is suggested that the lateral septum may receive afferent information from the gastrointestinal tract and promote gastric motility. Ghrelin plays an important role in promoting gastric motility in the lateral septum. The ARC may be involved in the regulation of the lateral septum's influence on gastric motility.

Bidirectional brain‐gut interactions: Involvement of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis

“…The microinjection of nesfatin‐1 into the CeA or the arcuate nucleus of the hypothalamus (Arc) reduces gastric motility in rats. On the other hand, the administration of ghrelin into the Arc, lateral septum, or lateral hypothalamic area (LHA) increases gastric motility in rats. Furthermore, the activation of α 1 ‐adrenoceptors within the NST causes a reduction in gastric tone in rats .…”

“…In the human brain, GD‐induced changes in neuronal activities have been observed in a number of brain regions, such as the insula, thalamus, anterior cingulate cortex, and amygdala, using positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) scans . On the other hand, pharmacological manipulations of various brain regions in rodents have been shown to affect gastric functions . Thus, the dysfunction of neurotransmission within these brain regions could be a possible mechanism underlying the pathology of FD.…”

“…[7][8][9] On the other hand, pharmacological manipulations of various brain regions in rodents have been shown to affect gastric functions. [10][11][12][13][14][15] Thus, the dysfunction of neurotransmission within these brain regions could be a possible mechanism underlying the pathology of FD.…”

Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms

“…Nucleus accumbens core and shell neurons, other key targets of VTA dopamine signaling, receive substantial innervation from the vSub (86–88). The lateral septum, recently associated with the control of gastric motility (89, 90) and sucrose hyperphagia (91), is another potential feeding-relevant efferent pathway arising from vSub (92, 93) and dorsal CA3 neurons (94). We hypothesize that these monosynaptic outputs from the hippocampus to hypothalamic, striatal, prefrontal cortical, and septal outputs are critical downstream targets for hippocampal neural processing of interoceptive feeding-relevant information.…”

The role of neuropeptide W in energy homeostasis

“…Within the CNS, there are other regions known to participate in the regulation of food intake, such as the nucleus tractus solitarius (NTS) in the brainstem, amygdala, cortex prefrontalis, septal nuclei and area postrema. [26][27][28] NPW and/or its receptors are expressed in some of these areas, as shown in Table 1. Whether NPW acts in these regions to modulate food intake, again, requires further investigation.…”