The role of neuropeptide W in energy homeostasis

Li, Hui; Kentish, Stephen J.; Wittert, Gary; Page, Amanda J.

doi:10.1111/apha.12884

Cited by 6 publications

(3 citation statements)

References 63 publications

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“…RB1CC1 is involved in cell growth and differentiation, senescence, apoptosis and autophagy, and was one of the genes differentially expressed in heat stressed chickens [ 29 , 30 ]. NPBWR1 modulates feeding behavior and energy homeostasis and PENK is responsible for producing enkephalins in response to stress [ 31 , 32 ]. Based on these findings and the fact that these shared regions between dEBV m and dEBV v showed effects beyond scale effects, we can conclude that the same gene can affect both, mean and its variability.…”

Section: Discussionmentioning

confidence: 99%

Genomic regions underlying uniformity of yearling weight in Nellore cattle evaluated under different response variables

Iung

Mulder

Neves³

et al. 2018

BMC Genomics

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BackgroundIn livestock, residual variance has been studied because of the interest to improve uniformity of production. Several studies have provided evidence that residual variance is partially under genetic control; however, few investigations have elucidated genes that control it. The aim of this study was to identify genomic regions associated with within-family residual variance of yearling weight (YW; N = 423) in Nellore bulls with high density SNP data, using different response variables. For this, solutions from double hierarchical generalized linear models (DHGLM) were used to provide the response variables, as follows: a DGHLM assuming non-null genetic correlation between mean and residual variance (rmv ≠ 0) to obtain deregressed EBV for mean (dEBVm) and residual variance (dEBVv); and a DHGLM assuming rmv = 0 to obtain two alternative response variables for residual variance, dEBVv_r0 and log-transformed variance of estimated residuals (ln_).ResultsThe dEBVm and dEBVv were highly correlated, resulting in common regions associated with mean and residual variance of YW. However, higher effects on variance than the mean showed that these regions had effects on the variance beyond scale effects. More independent association results between mean and residual variance were obtained when null rmv was assumed. While 13 and 4 single nucleotide polymorphisms (SNPs) showed a strong association (Bayes Factor > 20) with dEBVv and ln_, respectively, only suggestive signals were found for dEBVv_r0. All overlapping 1-Mb windows among top 20 between dEBVm and dEBVv were previously associated with growth traits. The potential candidate genes for uniformity are involved in metabolism, stress, inflammatory and immune responses, mineralization, neuronal activity and bone formation.ConclusionsIt is necessary to use a strategy like assuming null rmv to obtain genomic regions associated with uniformity that are not associated with the mean. Genes involved not only in metabolism, but also stress, inflammatory and immune responses, mineralization, neuronal activity and bone formation were the most promising biological candidates for uniformity of YW. Although no clear evidence of using a specific response variable was found, we recommend consider different response variables to study uniformity to increase evidence on candidate regions and biological mechanisms behind it.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-5003-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Genomic regions underlying uniformity of yearling weight in Nellore cattle evaluated under different response variables

Iung

Mulder

Neves³

et al. 2018

BMC Genomics

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“…In erythrocytes, there is an exhaustion of glutathione stocks which additionally causes the decrease of antioxidative enzymes' activity, increase peroxidation of cell membrane lipids and oxidative damages of hemoglobin. This may lead to hemolysis of erythrocytes and the release of heme iron and intensification of reaction of free radical among the endothelium 21,24–27…”

Section: Introductionmentioning

confidence: 99%

<p>Changes in the blood antioxidant defense of advanced age people</p>

Kozakiewicz¹,

Kornatowski²,

Krzywińska³

et al. 2019

CIA

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Introduction: Since 1956 there have been numerous scientific articles about free radical theory of aging which both confirm and deny the theory. Due to oxygen metabolism, there are relatively high concentrations of molecular oxygen in human cells, especially in mitochondria. Under normal physiological conditions, a small fraction of oxygen is constantly converted to ROS, such as superoxide radical (O2 −• ), H 2 O 2 , and related metabolites. Aim of the study: The aim of this work was to show the relation between the activity of main antioxidative enzymes and the age of the examined patients. Materials and methods: The analysis of antioxidant defense was performed on the blood samples from 184 “aged“ individuals aged 65–90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55–59 years. Results: The statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductase activities and malondialdehyde concentrations were observed. Conclusion: Lower activities of fundamental antioxidant enzymes in the erythrocytes of elderly people, which indicate the impairment of antioxidant defense in the aging organism and the intensity of peroxidative lipid structures, were observed.

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“…70 ROS generation by ZnONPs upon irradiation with UV light has been utilized for photo-triggered anticancer and antibacterial activities via ROS-induced damage to cell membranes, mitochondria, proteins, and DNA 31. The tumor suppressor protein p53 is a redox-active transcription factor that organizes cellular responses upon a range of stresses including intracellular induction of ROS 32. The increase in intracellular ROS is associated with the magnitude of p53 protein expression,33 which was also shown in the lung cancer A549 cells (Figure 6D) and the colon cancer HT29 cells (Figure 7D) while the opposite trend was observed in the breast cancer MCF-7 cells (Figure 8D).…”

Section: Resultsmentioning

confidence: 99%

<p>Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines</p>

Kim¹,

Perumalsamy²,

Castro-Aceituno³

et al. 2019

IJN

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BackgroundZinc oxide nanoparticles (ZnO NPs) are used in modern cancer therapy based on their specific target, efficacy, low toxicity and biocompatibility. The photocatalytic performance of Zinc oxide (ZnO) nanocomposites with hyaluronic acid (HA) was used to study anticancer properties against various human cancer cell lines.MethodsZinc oxide (ZnO) nanocomposites functionalized by hyaluronic acid (HA) were prepared by a co-precipitation method (HA-ZnONcs). The submicron-flower-shaped nanocomposites were further functionalized with ginsenoside Rh2 by a cleavable ester bond via carbodiimide chemistry to form Rh2HAZnO. The physicochemical behaviors of the synthesized ZnO nanocomposites were characterized by various analytical and spectroscopic techniques. We carried out 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay to evaluate the toxicity of Rh2HAZnO in various human cancer cells (A549, MCF-7, and HT29). Furthermore, to confirm the apoptotic effects of Rh2HAZnO and to determine the role of the Caspase-9/p38 MAPK pathways by various molecular techniques such as RT-PCR and Western blotting. Furthermore, Rh2HAZnO induced morphological changes of these cell lines, mainly intracellular reactive oxygen species (ROS) were observed by ROS staining and nucleus by Hoechst staining.ResultsWe confirmed that Rh2HAZnO exhibits the anti-cancer effects on A549 lung cancer, HT29 colon cancer, and MCF7 breast cancer cells. Moreover, intracellular reactive oxygen species (ROS) were observed in three cancer cell lines. Rh2HAZnO induced apoptotic process through p53-mediated pathway by upregulating p53 and BAX and downregulating BCL2. Specifically, Rh2HAZnO induced activation of cleaved PARP (Asp214) in A549 lung cancer cells and upregulated Caspase-9/phosphorylation of p38 MAPK in other cell lines (HT29 and MCF-7). Furthermore, Rh2HAZnO induced morphological changes in the nucleus of these cell lines.ConclusionThese results suggest that the potential anticancer activity of novel Rh2HAZnO nanoparticles might be linked to induction of apoptosis through the generation of ROS by activation of the Caspase-9/p38 MAPK pathway.

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The role of neuropeptide W in energy homeostasis

Cited by 6 publications

References 63 publications

Genomic regions underlying uniformity of yearling weight in Nellore cattle evaluated under different response variables

Genomic regions underlying uniformity of yearling weight in Nellore cattle evaluated under different response variables

<p>Changes in the blood antioxidant defense of advanced age people</p>

<p>Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines</p>

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