Effects of Gentiana lutea Root on Vascular Diseases

Joksić, Gordana; Radak, Djordje; Sudar-Milovanović, Emina; Obradović, Milan; Radovanović, Jelena; Isenović, Esma R.

doi:10.2174/1570161118666200529111314

Cited by 7 publications

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“…Gentiana scabra Bunge (GTSB), a traditional Chinese medicinal herb, exerts anti-in ammatory, antioxidant, anti-viral, and antimicrobial properties by means of the main chemical components of Gentian polysaccharide and gentiopicroside (Xu et al 2020;Joksic et al 2021;Zhao et al 2019). The source of wild GTSB has been seriously compromised owing to over-harvesting (Liu, Zuo, et al 2020) and the cultivated one has now become the principal commodity.…”

Section: Introductionmentioning

confidence: 99%

The characters of root-derived fungi from Gentiana scabra Bunge and the relations with their habitats

Wang

et al. 2023

Plant Soil

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Gentiana scabra Bunge (GTSB) root-derived fungi including endophytic fungi (EF) and rhizospheric fungi (RF) are key factors which in uence the quality and tness of this important herb. MethodsWe determined the population, diversity, and the dominant type of EF and RF in GTSB obtained from Liaoning, Yunnan and Jilin province, China by using ITS rRNA cloning and sequencing methods.Meanwhile, we investigated the potential in uence of different habitats on fungi communities, and analyzed the correlation between fungi communities, the main active metabolites of Gentian polysaccharide and gentiopicroside in GTSB and soil physicochemical properities. Results5,419 fungal isolates, belonging to 1 domain, 1 kingdom, 8 phyla, 32 classes, 104 orders, 280 families, 630 genera, 1,238 species were obtained. The population and diversity of EF and RF varied in both habitats and months, showing a signi cant difference. Among them, the predominant genera of EF were Lecidella and unclassi ed_p_Ascomycota, while the predominant genera of RF were complicated. Compared to EF, the diversity of rhizosphere fungi is more affected by soil physicochemical properties, including pH, water content, alkali-hydrolyzable nitrogen, available phosphorus, etc. Additionally, we found that the accumulation of gentiopicroside was positively correlated with EF of Epicoccum and RF of Mortierella, Solicoccozyma, Talaromyces and Trichoderma. The accumulation of Gentian polysaccharide was negatively correlated with EF of Lenzites, Mucor, Myrothecium and Saccharomycopsis and rhizosphere fungi, such as Botrytis, Cadophora, Cladophora, Didymela, Fusarium, etc. ConclusionsThis work will guide the development strategies to cultivate high-quality Gentiana scabra Bunge in the future and provide new ideas for the study of other medicinal plants.

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Section: Introductionmentioning

confidence: 99%

The characters of root-derived fungi from Gentiana scabra Bunge and the relations with their habitats

Wang

et al. 2023

Plant Soil

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“…A study reported that PV exerted anti-inflammatory properties in the RAW 264.7 cell inflammatory response by regulating PGE2 and NO secretion, which plays a central role in OA development [25]. GL, known as bitter root, yellow gentian, and bitterwort, belongs to the genus Gentiana in the family Gentianaceae [26]. Bioactive compounds of gentian promote anti-atherosclerotic [27], antioxidant [28], anti-obesity [29] and anti-inflammatory effects [27,28].…”

Section: Introductionmentioning

confidence: 99%

Anti-Osteoarthritic Effects of Prunella Vulgaris and Gentiana Lutea In Vitro and In Vivo

et al. 2022

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Osteoarthritis (OA) is the progressive destruction of articular cartilage with severe symptoms, including pain and stiffness. We investigated the anti-osteoarthritic effects of Prunella vulgaris (PV) and Gentiana lutea (GL) extract in primary cultured chondrocytes RAW 264.7 cells in vitro and destabilization of the medial meniscus (DMM)-induced OA mice in vivo. Primary chondrocytes were induced with IL-1β, and RAW 264.7 cells were treated with LPS and co-incubated with either individual extracts of PV and GL or different ratios of PV and GL mixture. For the OA animal model, the medial meniscus (DMM) was destabilized in 9-week-old male C57BL/6 mice. Treatment of individual PV and GL and combination of PV and GL extracts inhibited the mRNA expression level of COX2 in chondrocytes and RAW 264.7 cells. The optimized inhibitory effect was attained with a PV and GL combination at an 8:2 ratio (PG) without cytotoxic effects. PG extracts prevented the expression of catabolic factors (COX2, Mmp3, Mmp9, and Mmp13) and inflammatory mediator levels (PGE2 and collagenase). In addition, PG decreased subchondral sclerosis and increased BMD in the subchondral region of DMM-induced OA mice with protection of articular cartilage destruction by inhibiting inflammatory processes. This study suggests that PG may be an alternative medicinal herb for treatment of OA.

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Optimization of inoculum density to support root growth and secondary metabolite accumulation in root cultures of endangered Gentiana species: Gentiana lutea and Gentiana boissieri

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Demırcı

Albayrak

et al. 2022

In Vitro Cell.Dev.Biol.-Plant

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Effects of Gentiana lutea Root on Vascular Diseases

Cited by 7 publications

References 0 publications

The characters of root-derived fungi from Gentiana scabra Bunge and the relations with their habitats

The characters of root-derived fungi from Gentiana scabra Bunge and the relations with their habitats

Anti-Osteoarthritic Effects of Prunella Vulgaris and Gentiana Lutea In Vitro and In Vivo

Optimization of inoculum density to support root growth and secondary metabolite accumulation in root cultures of endangered Gentiana species: Gentiana lutea and Gentiana boissieri

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