Effects of gelatin addition on the microstructure of freeze-cast porous hydroxyapatite ceramics

Zhang, Yuan; Zuo, Kaihui; Zeng, Yu‐Ping

doi:10.1016/j.ceramint.2008.11.022

Cited by 65 publications

(36 citation statements)

References 15 publications

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“…water), is directionally frozen in a mold, then sublimated to remove the frozen liquid phase and sintered to densify the porous ceramics [16]. Several research groups have developed varying techniques for freeze-casting biocompatible ceramics, such as HA, for potential tissue engineering applications [17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Potential Bone Replacement Materials Prepared by Two Methods

et al. 2012

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Natural and synthetic hydroxyapatite (HA) scaffolds for potential load-bearing bone implants were fabricated by two methods. The natural scaffolds were formed by heating bovine cancellous bone at 1325°C, which removed the organic and sintered the HA. The synthetic scaffolds were prepared by freeze-casting HA powders, using different solid loadings (20-35 vol.%) and cooling rates (1-10°C/min). Both types of scaffolds were infiltrated with polymethylmethacrylate (PMMA). The porosity, pore size, and compressive mechanical properties of the natural and synthetic scaffolds were investigated and compared to that of natural cortical and cancellous bone. Prior to infiltration, the sintered cancellous scaffolds exhibited pore sizes of 100 -300 µm, a strength of 0.4 -9.7 MPa, and a Young's modulus of 0.1 -1.2 GPa. The freeze-casted scaffolds had pore sizes of 10 -50 µm, strengths of 0.7 -95

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Section: Introductionmentioning

confidence: 99%

Potential Bone Replacement Materials Prepared by Two Methods

et al. 2012

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“…In addition, it has been used for medical applications such as wound dressings, absorbent pads during surgery and as a scaffold for tissue engineering. Zhang et al, reported the addition of gelatin on HAp and its effect on the pore size and morphology of scaffolds [13]. HAp-gelatin composite microspheres were designed as effective devices for the controlled release of antibiotics.…”

Section: Introductionmentioning

confidence: 99%

“…HAp-gelatin composite microspheres were designed as effective devices for the controlled release of antibiotics. The HAp incorporated gelatin films were prepared by Biji et al and its structural and mechanical properties were investigated [11][12][13]. Carbonated HAp and β-TCP along with polymers such as agarose, gellan, poly(ethylene glycol) (PEG) and gelatin were used to prepare the scaffolds with hierarchical porous architectures which ensure an adequate vascularization and new tissue growth [3].…”

Section: Introductionmentioning

confidence: 99%

Freeze dried cross linking free biodegradable composites with microstructures for tissue engineering and drug delivery application

Joshy

Kolanthai

Sakthivel

et al. 2013

Materials Science and Engineering: C

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“…The above materials can be processed using several techniques, such as porogen leaching, gas foaming, phase separation, fiber meshing, supercritical fluid processing, microsphere sintering, and three-dimensional printing to generate a range of three-dimensional scaffolds with different porosities and surface characteristics [1]. Porous hydroxyapatite, a promising material in biomedical application, has been used as bone scaffold and drug carriers [24,25].…”

Section: Introductionmentioning

confidence: 99%