Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

Wang, Yuchuan; Guan, Mingyu; Zhao, Xin; Li, Xinli

doi:10.1080/13880209.2018.1479868

Cited by 86 publications

(44 citation statements)

References 31 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…f-Lachnospiraceae has been reported to be associated with anti-inflammatory activity [18], host mucosal integrity [19], the consumption of energy and the level of leptin [20]. Fructan [21,22] and whole garlic [23] have been reported to increase the abundance of f-Lachnospiraceae, but alliin was found to decreased it [24]. In particular, the relative abundance of g-Akkermansia decreased by aging and HFD diet, and increased by 5% AFG supplementation.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Allicin-Free Garlic on Gut Microbiome

Chen

Nakasone²,

Xie

et al. 2020

Molecules

View full text Add to dashboard Cite

The allicin diallyldisulfid-S-oxide, a major garlic organosulfur compound (OSC) in crushed garlic (Allium sativum L.), possesses antibacterial effects, and influences gut bacteria. In this study, we made allicin-free garlic (AFG) extract and investigated its effects on gut microbiome. C57BL/6N male mice were randomly divided into 6 groups and fed normal diet (ND) and high-fat diet (HFD) supplemented with or without AFG in concentrations of 1% and 5% for 11 weeks. The genomic DNAs of feces were used to identify the gut microbiome by sequencing 16S rRNA genes. The results revealed that the ratio of p-Firmicutes to p-Bacteroidetes increased by aging and HFD was reduced by AFG. In particular, the f-Lachnospiraceae, g-Akkermansia, and g-Lactobacillus decreased by aging and HFD was enhanced by AFG. The g-Dorea increased by aging and HFD decreased by AFG. In addition, the ratio of glutamic-pyruvic transaminase to glutamic-oxaloacetic transaminase (GPT/GOT) in serum was significantly increased in the HFD group and decreased by AFG. In summary, our data demonstrated that dietary intervention with AFG is a potential way to balance the gut microbiome disturbed by a high-fat diet.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulation of Allicin-Free Garlic on Gut Microbiome

Chen

Nakasone²,

Xie

et al. 2020

Molecules

View full text Add to dashboard Cite

show abstract

“…It contains high levels of potassium, phosphorus zinc, and sulfur, moderate levels of selenium, calcium, magnesium, manganese, iron, and low levels of sodium, vitamin A and C and B-complex [ 18 ]. In the last years, considerable attention has been given to its main bioactive compounds, particularly polyphenols, flavonoids, flavanols, tannins [ 5 , 19 ], saponins [ 4 ], polysaccharides [ 6 ], sulfur-containing compounds (including alliin, allicin, ajoene, allylpropyl disulfide, DATS, S-allylcysteine, vinyldithiins, SAMC), enzymes (like allinase, peroxidase, myrosinase), and other compounds, such as β-phellandrene, phellandrene, citral, linalool, and geraniol [ 3 ]. There are more than twenty well-known polyphenolic compounds in garlic, including kaempferol 3,7-di- O -rhamnoside, kaempferol-3 glucuronide, kaempferol-3- O -glucoside, kaempferol-3- O -beta- d -glucoside-7- O -alpha- l -rhamnoside, luteoline, and apigenine [ 20 ].…”

Section: Bioactive Compounds Of Garlicmentioning

confidence: 99%

“…In 1550 B.C., antibiotics and pharmacy products were not available so garlic was used for medicinal purposes in different epidemics, such as typhus, dysentery, cholera, and influenza [ 2 ]. The therapeutic effects of garlic are mainly due to the impressive activity of its bioactive compounds, such as organic sulfides [ 3 ], saponins [ 4 ], phenolic compounds [ 5 ], and polysaccharides [ 6 ]. For example, several in vitro and in vivo studies have showed that garlic compounds are able to modulate various signaling pathways, including nuclear factor-κB and wingless-related integration site [ 7 ], matrix metalloproteinases, nuclear factor erythroid 2 like 2, protein kinase B (pAkt), mitogen-activated protein kinase, c-Jun N-terminal kinases, caspases, p38, transforming growth factor beta 1 (TGF-β1), TGF-β type II receptor, psmad2/3, smad4 and smad7 [ 8 , 9 ], cytokines, intercellular adhesion molecule [ 10 ], notch pathway [ 11 ], 5’ AMP-activated protein kinase pathway [ 12 ], vascular endothelial growth factor [ 13 ], cyclooxygenase 2, inducible nitric oxide synthase, Akt/mTOR [ 14 ], and Keap1 [ 15 ], leading to improved anti-inflammatory and antioxidant properties, as well as chemopreventive, antiproliferative, anti-angiogenic, antidiabetic, and cardioprotective effects.…”

Section: Introductionmentioning

confidence: 99%

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

et al. 2020

View full text Add to dashboard Cite

Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed.

show abstract

“…Animals and humans exposed to alcohol chronically exhibit overgrowth of opportunistic pathogenic and depletion of beneficial intestinal bacteria. Lactobacillus, Clostridium butyricum and Bacteroides decreased in diabetic liver injury mice [81].…”

Section: Pathophysiology Of Alcoholic Liver Diseasementioning

confidence: 89%

Alcohol Induced Fatty Liver: A Tragic Inception of Wrong Turn

2019

ARC Journal of Nursing and Healthcare

View full text Add to dashboard Cite

Alcohol is a noteworthy reason for liver cirrhosis in the Western world and records for most of instances of liver cirrhosis found in region general emergency clinics in the UK. Alcoholic liver disease is a term that incorporates the liver appearances of alcohol overconsumption, including fatty liver, alcoholic hepatitis, and constant hepatitis with liver fibrosis or cirrhosis. As per the American Liver Foundation (ALF), somewhere in the range of 10 and 20 percent of substantial consumers will develop cirrhosis. The disease is a piece of a progression. It might begin with fatty liver disease, at that point advancement to alcoholic hepatitis, and after that to alcoholic cirrhosis. Be that as it may, it's conceivable an individual can develop alcoholic liver cirrhosis while never having alcoholic hepatitis. Symptoms of alcoholic liver cirrhosis regularly develop when an individual is between the ages of 30 and 40. All things considered, it takes around one hour for the body to utilize (separate) one standard beverage as characterized by U.S. rules (for example 12 ounces of 4.5% brew, 5 ounces of 11% wine, or 1.5 ounces of 35% alcohol). Utilization of 60-80g every day (14g is viewed as one standard beverage in the US, i.e., 1.5 fl oz hard alcohol, 5 fl oz wine, 12 fl oz lager; drinking a six-pack of brew day by day would be amidst the range) for a long time or more in men, or 20g/day for ladies fundamentally builds the danger of hepatitis and fibrosis by 7% to 47%. Of all endless substantial consumers, just 15-20% develop hepatitis or cirrhosis, which can happen correspondingly or in progression. The purpose for is accepted to be the liver has gigantic ability to recover and notwithstanding when 75% of hepatocytes are dead, it keeps on working as should be expected. As indicated by NIAAA (1993), somewhere in the range of 10% and 35% of substantial consumers develop alcoholic hepatitis. While development of hepatitis isn't specifically identified with the portion of alcohol, a few people appear to be more prone to this response than others. This is called alcoholic steato-necrosis (Steatosis) and the inflammation seems to incline to liver fibrosis.

show abstract

Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice

Cited by 86 publications

References 31 publications

Modulation of Allicin-Free Garlic on Gut Microbiome

Modulation of Allicin-Free Garlic on Gut Microbiome

Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview

Alcohol Induced Fatty Liver: A Tragic Inception of Wrong Turn

Contact Info

Product

Resources

About