Effects of Garlic on 7,12-Dimethylbenz[a]anthracene-Induced Hamster Buccal Pouch Carcinogenesis

Balasenthil, Seetharaman; Arivazhagan, S.; Ramachandran, C. R.; Nagini, Siddavaram

doi:10.1046/j.1525-1500.1999.99050.x

Cited by 53 publications

(30 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, we have reported dose-dependent protection of tomato paste against DMBA-induced genotoxicity and oxidative stress in mice as well as the incidence of hamster buccal pouch tumors (4,9). The antigenotoxic and anticarcinogenic effects of garlic and its organosulfur constituent SAC have also been reported by us as well as by others (3,5,9).…”

Section: Bhuvaneswari Et Alsupporting

confidence: 52%

“…Epidemiological studies have provided evidence that an increased intake of tomato and garlic is associated with a decreased cancer risk (2,3). In previous studies from this laboratory, we demonstrated the modulatory effects of tomato and garlic on lipid peroxidation, antioxidant and detoxification systems during chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis (4,5).…”

Section: Bhuvaneswari Et Almentioning

confidence: 85%

See 1 more Smart Citation

Tomato and garlic by gavage modulate 7,12-dimethylbenz[a]anthracene-induced genotoxicity and oxidative stress in mice

Bhuvaneswari

Velmurugan

Abraham

et al. 2004

Braz J Med Biol Res

Self Cite

View full text Add to dashboard Cite

Chemoprotection by dietary agents is a promising strategy for cancer prevention. The aim of the present study was to evaluate the combined effect of tomato and garlic against 7,12-dimethylbenz-[a]anthracene (DMBA)-induced genetic damage and oxidative stress in 12-14-week-old male Swiss albino mice. The animals were randomized into experimental and control groups and divided into eight groups of five animals each. Group 1 animals were injected intraperitoneally with 35 mg/kg body weight DMBA suspended in peanut oil as a single dose. Groups 2-4 animals received tomato (500 mg/kg body weight), garlic (125 mg/kg body weight) and a combination of tomato and garlic for 5 days by gavage, respectively, followed by DMBA 1.5 h after the final feeding. The doses of tomato and garlic correspond to the average human daily consumption. Animals in groups 5, 6 and 7 received tomato alone, garlic alone and tomato + garlic combination, respectively, for 5 days. Group 8 animals received the same volume of water and served as control. The incidence of bone marrow micronuclei and the extent of lipid peroxidation and the concentrations of antioxidants glutathione, glutathione peroxidase and glutathione-S-transferase were measured in the liver, 48 h after DMBA exposure. Increased frequency of micronuclei and enhanced lipid peroxidation accompanied by compromised antioxidant defenses were observed in DMBA-treated animals. Although pretreatment with tomato or garlic significantly reduced the frequency of DMBAinduced bone marrow micronuclei, the combination of tomato and garlic exhibited more profound effect in inhibiting DMBA-induced genotoxicity and oxidative stress. We suggest that a broad spectrum of antimutagenic and anticlastogenic effects can be achieved through an effective combination of functional foods such as tomato and garlic.

show abstract

Section: Bhuvaneswari Et Alsupporting

confidence: 52%

Section: Bhuvaneswari Et Almentioning

confidence: 85%

Tomato and garlic by gavage modulate 7,12-dimethylbenz[a]anthracene-induced genotoxicity and oxidative stress in mice

Bhuvaneswari

Velmurugan

Abraham

et al. 2004

Braz J Med Biol Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Balasenthil and coworkers have investigated the effect of aqueous extract of garlic on lipid peroxidation and levels of antioxidants during buccal pouch carcinogenesis in hamsters. They observed that the administration of AGE diminished lipid peroxidation in oral tumor tissue and increased GSH level and glutathione peroxidase activity [Balasenthil et al, 1999]. AGE inhibited LDL oxidation and minimized endothelial cell injury by preventing depletion of intracellular GSH and by removing peroxides [Ide and Lau, 1999].…”

Section: Antioxidant Effects Of Garlic and Aged Garlic Extractmentioning

confidence: 99%

Biological properties of garlic and garlic‐derived organosulfur compounds

Iciek

Kwiecień

Włodek

2009

Environ and Mol Mutagen

364

266

View full text Add to dashboard Cite

Medicinal properties of garlic (Allium sativum) have been widely known and used since ancient times till the present. Garlic enhances immune functions and has antibacterial, antifungal and antivirus activities. It is known to prevent platelet aggregation, and to have hypotensive and cholesterol- and triglyceride-lowering properties, although the latter features have been questioned. This review is focused on anticancer efficacy of Allium sativum, and attempts to explain the mechanisms of this action. Medicinal properties of garlic rely upon organosulfur compounds mostly derived from alliin. Organosulfur compounds originating from garlic inhibit carcinogen activation, boost phase 2 detoxifying processes, cause cell cycle arrest mostly in G2/M phase, stimulate the mitochondrial apoptotic pathway, increase acetylation of histones. Garlic-derived sulfur compounds influence also gap-junctional intercellular communication and participate in the development of multidrug resistance. This review presents also other little known aspects of molecular action of garlic-derived compounds, like modulation of cellular redox state, involvement in signal transduction and post-translational modification of proteins by sulfane sulfur or by formation of mixed disulfides (S-thiolation reactions).

show abstract

“…Alliin and one of its metabolites, allicin, have also been found to show tumor-inhibiting effects (Lawson, 1998;Dorant, 1993). Since then, although a number of studies have been made on the antitumor and cytotoxic actions of garlic and its organosulfur constituents (Hayes et al, 1987;Wargovich et al, 1988;Balasenthil, 1999;Siegers et al, 1999;Hong et al, 2000;Lamm et al, 2000) the precise mechanisms of the anticarcinogenic action of garlic are not completely known. In another study, it has been established that garlic components affect the N-acyltransferase activity of human bladder tumor cells (Chung, 1999).…”

Section: Introductionmentioning

confidence: 99%

Effects of garlic and black grape extracts on the activity of adenosine deaminase from cancerous and noncancerous human urinary bladder tissues

et al. 2007

View full text Add to dashboard Cite

Aim Possible effects of garlic (Allium sativum) and black grape (Fructus vitis minuta) with known antioxidant potential on adenosine deaminase (ADA) activities were investigated in cancerous and noncancerous human bladder tissues. Methods The effects of garlic and black grape extracts on adenosine deaminase (ADA) activities were measured in 20 pairs of cancer and adjacent normal human bladder tissues with and without pre-incubation with garlic and black grape extracts at different concentrations. Results No significant difference was observed between ADA activities in cancerous and non cancerous bladder tissues without plant extract (5.85 AE 3.78 versus 7.63 AE 2.88, respectively). At the 1/3 and 1/1 plant extract/bladder tissue homogenate ratios, the garlic extract completely abolished the ADA activity in both cancerous and noncancerous tissues. At the 1/3 plant extract/bladder tissue homogenate ratio, the black grape extract decreased the activity significantly as compared to without extract (2.01 AE 1.30 versus 5.85 AE 3.78; p \ 0.05 for cancerous tissue and 2.10 AE 1.66 versus 7.63 AE 2.88; p \ 0.05 for noncancerous tissue) and, at the 1/1 plant extract/bladder tissue homogenate ratio, completely abolished the activity. Conclusion Our results show that garlic and black grape have potential to inhibit ADA activity in both cancerous and adjacent normal human bladder tissues.We suggest that this might be rational basis for the uses of garlic and black grape in the complementary therapy of urinary bladder cancer. _ I. Durak Á _

show abstract

Effects of Garlic on 7,12-Dimethylbenz[a]anthracene-Induced Hamster Buccal Pouch Carcinogenesis

Cited by 53 publications

References 19 publications

Tomato and garlic by gavage modulate 7,12-dimethylbenz[a]anthracene-induced genotoxicity and oxidative stress in mice

Tomato and garlic by gavage modulate 7,12-dimethylbenz[a]anthracene-induced genotoxicity and oxidative stress in mice

Biological properties of garlic and garlic‐derived organosulfur compounds

Effects of garlic and black grape extracts on the activity of adenosine deaminase from cancerous and noncancerous human urinary bladder tissues

Contact Info

Product

Resources

About