Effects of Garcinia kola biflavonoid fractions on serum lipid profile and kidney function parameters in hyperlipidemic rats

Adejor, Ene Blessing; Ameh, D. A.; James, Dorcas Bolanle; Owolabi, O. A.; Ndidi, Uche Samuel

doi:10.1186/s40816-016-0033-4

Cited by 14 publications

(15 citation statements)

References 27 publications

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“…Moreover, several experimental researches related to the effect of Garcinia kola seed on serum lipids were carried out on animals [10,14,15]. Adaramoye et al [14] have reported that the oral administration during 3 to 7 days of kolaviron (a biflavonoid extracted from the Garcinia kola seed) to alloxan-induced diabetic rats, results in the lowering of triglycerides, total cholesterol and LDL cholesterol.…”

Section: Discussionmentioning

confidence: 99%

“…Duze et al [15] found out a decline in the LDL cholesterol among diabetes-induced rats compared to the focus group, after oral administration during four weeks of 300 mg/kg of extracts of Garcinia kola seed. The administration of extracts of Garcinia kola seed (200 mg/kg) to hyperlipemia-induced rats in the research works of Adejor et al [10] showed that after 21 days, total cholesterol, triglycerides and LDL cholesterol were significantly lower compared to control group among the same population of rats. Omeh et al [16] had published a trial on Wistar albino rats fed with foods fortified with Garcinia kola powder of concentrations graduated at 5%, 10%, 20% et 50% during 21 consecutive days.…”

Section: Discussionmentioning

confidence: 99%

“…The study conducted by Adaramoye and Adeyemi [9] has emphasized the lipid-lowering effects of slices of kolaviron (a biflavonoid of Garcinia kola) in rats. The administration of extracts of Garcinia kola seed to hyperlipemia-induced rats has showed that, after 21 days, total cholesterol, triglycerides and LDL cholesterol were significantly lower compared to the control group in the works of Adejor et al [10]; the same authors observed a significant increase in HDL cholesterol, and a decline in the atherogenic index of plasma among the same population of rats. Uche and Osakpolor [11] reported an improvement of dyslipidemia through a decline in rates of total cholesterol, HDL cholesterol and triglycerides among rats after administration of Garcinia kola seed extracts.…”

Section: Introductionmentioning

confidence: 94%

“…Several previous research works [9][10][11] have focused on the effects of extracts of Garcinia kola seeds on lipid metabolism in experimental animals. The study conducted by Adaramoye and Adeyemi [9] has emphasized the lipid-lowering effects of slices of kolaviron (a biflavonoid of Garcinia kola) in rats.…”

Section: Introductionmentioning

confidence: 99%

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Effect of the Garcinia kola Seed on Serum Lipids in Adult Subjects

Gomina

Salifou

Djidonou

et al. 2020

AJRB

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Background: Many studies have reported the lipid-lowering effect of the Garcinia kola seed in experimental animals. Objective: Assessing the effect of daily intake of Garcinia kola seed on serum lipids in adult subjects. Methods: This research work was an intervention study based on a quasi-experimental approach carried out over a three-month period i.e. from May 1 to July 30, 2019. The study sample consisted of 40 adult subjects (18 men and 22 women) who gave their written informed consent to participate to in the study. After receiving required information, each subject underwent a baseline lipid test consisting of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) and triglycerides. Then, each subject consumed every day one Garcinia kola seed during 90 days. Every 30 days, a lipid test was performed. TC, HDL-C and triglycerides were determined using end-point colometric enzyme assay. LDL-C was estimated using the formula of Friedewald. Student’s t test helped compare the mean values of lipid parameters at the beginning and at the end of the experiment at the threshold of 5%. Results: At the beginning and at the end of the experiment, the mean values in g/L of TC (1.68±0.35 vs 1.60±0.31), HDL-C (0.53±0.13 vs 0.51±0.14), LDL-C (0.97±0.36 vs 0.94±0.34) and triglycerides (0.91±0.50 vs 0.72±0.33) were not significantly different (p > 0.05). However, we noted a downward trend in those values over time during the experiment. Conclusion: The daily consumption of Garcinia kola seed improves serum lipid profile. The use of that seed is a potential alternative to the conventional treatment of dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Effect of the Garcinia kola Seed on Serum Lipids in Adult Subjects

Gomina

Salifou

Djidonou

et al. 2020

AJRB

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“…Hyperlipidemia is a lipid disorder that alters lipid profile. It is characterized by elevated serum total cholesterol, low‐density lipoprotein cholesterol, and very‐low‐density lipoprotein cholesterol, and decreased high‐density lipoprotein cholesterol levels though may be asymptomatic (Adejor, Danladi, Dorcas, Olumuyiwa, & Uche, ).…”

Section: Discussionmentioning

confidence: 99%

Effect of ethanol extract of boiled breadfruit (Treculia Africana) seed on the oral glucose tolerance, lipid profile, and body weight of normoglycemic albino rats

Eleazu

Maduabuchi

Eleazu

2018

Food Science & Nutrition

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The effect of ethanol extracts of boiled Treculia africana seed on the oral glucose tolerance (OGTT), lipid profile, and body weight of normoglycemic albino rats was determined. Fifteen male albino rats were used and were divided into three groups of five rats each. Groups 1 and 2 received 100 and 200 mg/kg of the extract, while group 3 (control group) received 1 ml/kg of normal saline. The experiment lasted for 28 days. The body weights of the rats were determined daily. OGTT was determined at week zero (before extract administration) and at weeks 2 and 4, respectively, following extract administration. Glycemic index (GI) of the extracts was calculated from the incremental area under the OGTT curve. The total cholesterol, high‐density lipoprotein (HDL) cholesterol, low‐density lipoprotein (LDL) cholesterol, and very‐low‐density lipoprotein (VLDL) cholesterol levels in the sera of the rats were determined using standard techniques. Atherogenic index (AI) and coronary risk index (CRI) of the rats were expressed as ratios of LDL cholesterol to HDL cholesterol and total cholesterol to HDL cholesterol, respectively. Following 2 weeks of the extract administration, the blood glucose for groups 1 and 2 rats declined to values ≤100 mg/dl after oral glucose loading. GI for the standard rat feeds and the extracts at 100 and 200 mg/kg by the second week of experimentation were 100, 114, and 96.09, respectively. GI for the extract at 100 mg/kg decreased to 103.63 at the 4th week, while that for the extract at 200 mg/kg increased to 98.07. The extract at 100 mg/kg increased the LDL cholesterol, AI, and CRI of the rats, suggesting that consumption of boiled African breadfruit may expose an individual to the risk of development of cardiovascular diseases. Finally, the study suggested that consumption of T. africana seed by a nondiabetic subject may have no effect on the glucose tolerance of the individual, while it will negatively impact on the glycemic status of a diabetic subject.

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