Background:The lipid lowering effects of Nigella sativa extracts have been reported in numerous research works. In Benin, Nigella sativa seeds are consumed by the populations in order to treat various ailments and diseases. Objective: This study was aimed to assess the effect of daily consumption of Nigella sativa seed on serum lipids in adult subjects. Methods: This research work, being an interventional study of quasi-experimental category, involved 67 voluntary adult subjects (mean age: 33.51±11.40 years; 32 men; 35 women), conducted in Parakou (Benin), from January 15 to April 14, 2021. Each subject consumed per day two (2) grams of Nigella sativa seed powder during 90 consecutive days. The lipid parameters were measured before starting the experiment, and then during all the 30 days. Student's t test helped compare the averages of lipid parameters at the threshold of 5%. Results: The intake of Nigella sativa seed powder reduced significantly total cholesterol (1.83±0.47 g/L vs. 1.64±0.32 g/L; P=0.000), LDL cholesterol (1.08±0.44 g/L vs. 0.90±0.29 g/L; P=0.000) and triglycerides (1.01±0.60 g/L vs. 0.87±0.48 g/L; P=0.003). HDL cholesterol experienced a nonsignificant increase (0.53±0.19 g/L vs. 0.56±0.12 g/L; P=0.146) within a range of 5.70%. The following rates of decline were noted: total cholesterol (10.40%), LDL cholesterol (16.70%) and triglycerides (13.90%). Conclusion: At the end of the 90 days, the Nigella sativa seed powder improves the lipid profile in the adult subject. Its consumption may be helpful in the prevention and management of dyslipidemias.
This study was aimed to access the variations in serum lipid parameters based on the prandial state of adult patients. Through a cross-sectional descriptive and analytical study conducted in Parakou (Benin), from February 1 to May 1, 2020, 100 adult subjects (average age 31.21±12.36 years) were selected with systematic census. After ethical advice, a first sample was taken on empty-bellied adult subjects. Then, three additional samples were respectively taken two hours, four hours, and six hours after these subjects had eaten a meal of their choice. Serum lipid parameters were measured through enzymatic colorimetric methods. The average values of fasting lipid parameters in g/L were: Total cholesterol (1.48±0.35), HDL cholesterol (0.49±0.14), LDL cholesterol (0.84±0.36) and triglycerides (0.63±0.34). The comparison of the fasting and postprandial lipid parameters values is presented as follow: Triglyceridemia was significantly higher 2 h (P=0.000) and 4 h after meal (P=0.001). Only one type of food consumed was associated with mixed hyperlipidemia at six hours postprandial state (P=0.022). It may therefore be concluded that consumed foods do not cause most dyslipidemias 6 h in the postprandial state. During the screening for dyslipidemias in adults, the lipid profile can therefore be measured after six hours postprandial state.
Background: Many studies have reported the lipid-lowering effect of the Garcinia kola seed in experimental animals. Objective: Assessing the effect of daily intake of Garcinia kola seed on serum lipids in adult subjects. Methods: This research work was an intervention study based on a quasi-experimental approach carried out over a three-month period i.e. from May 1 to July 30, 2019. The study sample consisted of 40 adult subjects (18 men and 22 women) who gave their written informed consent to participate to in the study. After receiving required information, each subject underwent a baseline lipid test consisting of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) and triglycerides. Then, each subject consumed every day one Garcinia kola seed during 90 days. Every 30 days, a lipid test was performed. TC, HDL-C and triglycerides were determined using end-point colometric enzyme assay. LDL-C was estimated using the formula of Friedewald. Student’s t test helped compare the mean values of lipid parameters at the beginning and at the end of the experiment at the threshold of 5%. Results: At the beginning and at the end of the experiment, the mean values in g/L of TC (1.68±0.35 vs 1.60±0.31), HDL-C (0.53±0.13 vs 0.51±0.14), LDL-C (0.97±0.36 vs 0.94±0.34) and triglycerides (0.91±0.50 vs 0.72±0.33) were not significantly different (p > 0.05). However, we noted a downward trend in those values over time during the experiment. Conclusion: The daily consumption of Garcinia kola seed improves serum lipid profile. The use of that seed is a potential alternative to the conventional treatment of dyslipidemia.
Background: The administration of extracts of Garcinia kola seed to experimental rats has a hypoglycemic and hepatoprotective effect. Objective: Assess the effect of daily consumption of Garcinia kola seed on glycemia, creatinine and serum aminotransferases among adult subjects. Methods: We carried out an intervention study based on quasi-experimental approach during three months i.e. from May 1 to July 30, 2019. A sample consisting of 40 adult subjects (18 men, 22 women) had participated to the study after their written consent and approval by the institutional ethics committee. After the baseline testing which consists of fasting glycemia, creatininemia, alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT), each subject consumed one Garcinia kola seed per day during 90 days. Then, every 30 days, the same testing was performed. Glycemia was determined by endpoint colometric method for assaying enzyme using glucose oxidase; creatinine by colometric kinetic assay using the JAFFE reagent; and aminotransferases by UV enzyme kinetics. Student’s t test helped compare the mean values of the parameters determined at the beginning and at the end of the experiment at the threshold of 5%. Results: The mean values at the beginning and at the end of the experiment were glycemia in g/L (0.81± 0.20 vs 0.84 ± 0.14), creatininemia in mg/L (9.36 ± 2.44 vs 8.01 ± 2.15), ALAT in UI/L (27.19 ± 15.77 vs 25.60 ± 12.45) and ASAT in UI/L (28.46 ± 11.52 vs 23.30 ± 8.48). A significant decrease of creatininemia and ASAT was observed (p = .010 and .025 respectively). Conclusion: The consumption of the Garcinia kola seed has a nephroprotective and hepatoprotective effect.
Background: Daily consumption of fruits is recommended due to their positive impact on the control of glycemia, cholesterol and coronary heart disease. Objectives: This study aimed to determine the glycemic index and glycemic load (GL) of four local fruits grown in Benin, namely papaya, pineapple, watermelon and grafted mango, among apparently healthy young adult subjects. Methods: This research work, being an interventional study of quasi-experimental category, involved 33 voluntary adult subjects (mean age: 23.4±1.9 years; mean body mass index: 21.38±1.89 kg/m2 ) distributed into 4 groups. The subjects of each group consumed the reference food (25 g of glucose or 50 g of white bread) twice a week with an interval of one week, and then a serving equivalent to 25 g of carbohydrates of each tested fruit in the morning after a 12-hour fasting on the evening. Plasma glucose was measured at 0, 15, 30, 45, 60, 90, and 120 minutes after food ingestion. Data were analyzed by one-way analysis of variance (ANOVA, SPSS, 26). The P < 0.05 was regarded as the significance level. Results: The incremental area under the curve mean value in mmol.L-1.min-1 of pineapple (89.21±21.75) was higher (P <0.001) than those of mango (34.71±13.62), papaya (23.46±15.06) and watermelon (20.30±16.47). The mean glycemic index of mango (117.09±58.32) was significantly higher (P =0.007) than the ones of pineapple (52.97±29.87), papaya (46.77±45.77), and watermelon (41.04±34.06). The mean GL of mango (16.28±8.11) was significantly more elevated (P =0.001) than the ones of papaya (3.41±3.34), pineapple (6.36±3.58), and watermelon (2.54±2.11). Conclusion: Watermelon, papaya and pineapple may therefore be recommended for safe consumption in accordance with dietary guidelines.
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