Effects of gammahydroxybutyric acid (GHB) on memory tested in the hole-board in male mice

Luna, Gema; Barrero, F.; Pedraza, C.; Dávila, Guadalupe; Martín, M.; Navarro, José Francisco

doi:10.1016/s0924-977x(02)80643-5

Cited by 3 publications

(2 citation statements)

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“…In monkeys, GHB failed to have any effect on the go/no-go visual discrimination task (Nakamura et al , 1987). Navarro and coworkers studied the effects of chronic low doses of GHB (5–100 mg/kg for 12 – 30 days) on the “hole-board” task performance in adult mice, and reported that working memory was significantly reduced in GHB-treated mice compared to controls (Davila et al , 2004; Garcia et al , 2006; Luna et al , 2002). In another study, GHB was reported to decrease operant behavior but not working memory in adult rats (Laraway et al , 2008).…”

Section: Introductionmentioning

confidence: 99%

Effects of γ-hydroxybutyric acid on spatial learning and memory in adolescent and adult female rats

Sircar

Basak

Sircar

et al. 2010

Pharmacology Biochemistry and Behavior

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Abstractγ-hydroxybutyric acid (GHB) has been reported to disrupt spatial learning and memory in adolescent male rats. The present study was undertaken to determine the effects of GHB on the acquisition of spatial memory in adolescent female rats, and to investigate age specificity of the behavioral impairments. Adolescent female rats were subjected to repeated GHB or saline administrations, and tested in the Morris water maze. Compared to age-matched saline controls, adolescent GHB-treated rats took significantly longer and swam greater distances to find the hidden platform. In the probe trial, GHB-treated adolescent rats spent less time in the target quadrant than saline-treated controls. There was no difference in either the swim speed or in the visual task performance between GHB-treated and saline-treated rats. To test for ontogenic specificity of the behavioral responses, adult female rats were treated with GHB and tested behaviorally in two separate experiments using a 6-day learning protocol (Experiment 1) and a 16-day learning protocol (Experiment 2). In the 6-day spatial learning and memory task, adult salinetreated rats failed to learn the task, and GHB did not alter the latency to find the platform, or performance in the probe trial. In the second behavioral protocol, a modified version of the memory task was used to test adult animals. The number of test days was increased from 6 days to 16 days. Adult saline-treated females learned the task in the 16-days protocol. But unlike in adolescent female rat, GHB in adult rats had minimal effects on reference memory even when they had learned the spatial memory task. Performances in the probe trial by GHB-treated rats and saline controls were similar. Together, these data suggest that GHB impairs spatial learning specifically in adolescent female rats.

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Section: Introductionmentioning

confidence: 99%

Effects of γ-hydroxybutyric acid on spatial learning and memory in adolescent and adult female rats

Sircar

Basak

Sircar

et al. 2010

Pharmacology Biochemistry and Behavior

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“…In monkeys, GHB failed to have any effect on the go/no-go visual discrimination task [ 7 ]. Navarro and coworkers studied the effects of chronic low doses of GHB (5-100 mg/kg for 12 - 30 days) on the “hole-board” task performance in adult mice, and reported that working memory was significantly reduced in GHB-treated mice compared to controls [ 8 - 10 ]. In adult rats, GHB has been shown to decrease operant behavior but not working memory [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

GHB – Induced Cognitive Deficits During Adolescence and the Role of NMDA Receptor

Sircar

Wu²,

Reddy³

et al. 2011

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We have earlier reported that γ-hydroxybutyric acid (GHB) disrupts the acquisition of spatial learning and memory in adolescent rats. GHB is known to interact with several neurotransmitter systems that have been implicated in cognitive functioning. The N-methyl-D-aspartate receptor (NR) -type of glutamate receptor is considered to be an important target for spatial learning and memory. Molecular mechanisms governing the neuroadptations following repeated GHB treatment in adolecent rats remain unknown. We examined the role of NMDA receptor in adolescent GHB-induced cognitive deficit. Adolescent rats were administered with GHB on 6 consecutive days, and surface-expressed NMDA receptor subunits levels were measured. GHB significantly decreased NR1 levels in the frontal cortex. Adolescent GHB also significantly reduced cortical NR2A subunit levels. Our findings support the hypothesis that adolescent GHB-induced cogntive deficits are associated with neuroadaptations in glutamatergic transmission, particulaly NR functioning in the frontal cortex.

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Gamma-hydroxybutyrate (GHB) reduces operant behavior without impairing working memory in rats responding under fixed-consecutive-number schedules

Laraway

Snycerski

Baker

et al. 2008

Pharmacology Biochemistry and Behavior

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Effects of gammahydroxybutyric acid (GHB) on memory tested in the hole-board in male mice

Cited by 3 publications

References 0 publications

Effects of γ-hydroxybutyric acid on spatial learning and memory in adolescent and adult female rats

Effects of γ-hydroxybutyric acid on spatial learning and memory in adolescent and adult female rats

GHB – Induced Cognitive Deficits During Adolescence and the Role of NMDA Receptor

Gamma-hydroxybutyrate (GHB) reduces operant behavior without impairing working memory in rats responding under fixed-consecutive-number schedules

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