Effects of GABAB receptor antagonism on the development of Pentylenetetrazol-induced kindling in mice

Getova, D.; Froestl, Wolfgang; Bowery, Norman G.

doi:10.1016/s0006-8993(98)00864-6

Cited by 40 publications

(12 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with previous reports that GABA B antagonists produce no overt behavioral effects when administered alone at doses that completely block the actions of GABA B agonists (Getova et al 1997(Getova et al , 1998Heese et al 2000;Barreto Zaleski et al 2001).…”

Section: Discussionsupporting

confidence: 93%

The GABA B antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat

2002

Self Cite

View full text Add to dashboard Cite

The specific GABA(B) antagonist CGP56433A attenuated the effect of baclofen on cocaine self-administration, suggesting that GABA(B) receptors are critical in mediating the anti-cocaine effect of baclofen. In combination with other studies, the data demonstrate that the susceptibility of baclofen and other GABA(B) agonists to receptor blockade depends on the behavioral response being studied. Whether this indicates different receptor mechanisms are involved (e.g., pre- versus post-synaptic effects or differential receptor reserve) remains to be determined.

show abstract

Section: Discussionsupporting

confidence: 93%

The GABA B antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat

2002

Self Cite

View full text Add to dashboard Cite

show abstract

“…[38] There are findings about alterations in GABAB receptor mechanisms during kindling according to results of learning and memory studies done with PTZ kindling method. [39] In addition, it is reported that levels of GABA transporters can be a determinant for seizure vulnerability and epileptogenesis. [40] Changes in glutamergic system PTZ also causes an alteration in density and sensitivity of different glutamate receptor sub types [41] in many parts of the brain and an increase in density of glutamate neurotransmitter at the hippocampal region.…”

Section: Alterations In Gabaergic Systemsmentioning

confidence: 99%

“…[44] Long term neocortical plasticity aroused by kindling; can be generated by an alteration in the delicate balance between neuronal inhibition and excitation (a relative decrease in Pentylenetetrazole Kindling Epilepsy Model inhibition and a relative increase in excitation or a combination of both). [39] Kindling causes an enhancement in the release of GABA in hippocampus and a decrease in GABA receptor sensitivity. PTZ induced convulsions start by glutamate receptor activation and inhibition of inhibitor GABA neurotransmitters and proceed into generalized form.…”

Section: Alterations In Gabaergic Systemsmentioning

confidence: 99%

Pentylenetetrazol Kindling Epilepsy Model

Erkeç¹,

Arıhan²

2015

Epilepsi

View full text Add to dashboard Cite

SummaryEpilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs. Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects. These therapies do not cure epilepsy. Basic mechanisms of epilepsy have not entirely been clarified yet. Using seizure and epilepsy animal models, our comprehension about basic mechanisms underlying epileptogenesis has improved. In addition, animal models of epilepsy and seizures are very useful in the discovery and development of new antiepileptic drugs. Pentylenetetrazole (PTZ) is widely used in antiepileptic drug discovery studies, and PTZ kindling model is very important to understand the pathophysiology of epilepsy. In this review, current information about PTZ kindling model was given in this aspect.Key words: Chemical kindling; epilepsy; experimental animal models; pentylenetetrazole; rat. ÖzetEpilepsi genel popülasyonun yaklaşık %1'ini etkileyen en yaygın nörolojik düzensizliklerden biridir. Antiepileptik ilaç tedavisi gören hastaların üçte birinde hiçbir hafifleme elde edilememektedir. Epilepsi için kullanılan güncel tedaviler semptomatiktir ve antiepileptik etkiden ziyade anti nöbet etkilidir. Bu tedaviler epilepsiyi tedavi etmemektedir. Epilepsinin temel mekanizmaları da henüz tam olarak anlaşılamamıştır. Nö-bet ve epilepsi hayvan modelleri kullanılarak epilepsinin temelinde yatan mekanizmaları kavrayışımız ilerlemektedir. Ayrıca epilepsi ve nöbet hayvan modelleri yeni antiepileptik ilaç keşfi ve gelişimi bakımından kullanışlıdırlar. Pentilentetrazol (PTZ), antiepileptik ilaç keşif çalışmala-rında yaygın biçimde kullanılmaktadır ve PTZ tutuşma modeli epilepsinin patofizyolojisinin anlaşılması bakımından oldukça önemlidir. Bu

show abstract

“…Getova and Bowery, 1998; Nakagawa 601 et al, 1999) and induce plasticity and long-term potentia-602 tion in the CA1 region of their hippocampal slices.A close relationship was found between glutamate 604 and GABA systems with regard to cognitive and non-…”

mentioning

confidence: 99%

The modulatory effect of CA1 GABAb receptors on ketamine-induced spatial and non-spatial novelty detection deficits with respect to Ca2+

Khanegheini¹,

Nasehi²,

Zarrindast³

2015

Neuroscience

View full text Add to dashboard Cite

Effects of GABAB receptor antagonism on the development of Pentylenetetrazol-induced kindling in mice

Cited by 40 publications

References 16 publications

The GABA B antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat

The GABA B antagonist CGP56433A attenuates the effect of baclofen on cocaine but not heroin self-administration in the rat

Pentylenetetrazol Kindling Epilepsy Model

The modulatory effect of CA1 GABAb receptors on ketamine-induced spatial and non-spatial novelty detection deficits with respect to Ca2+

Contact Info

Product

Resources

About