Effects of fusaric acid and its derivative on the cardiovascular system

Furuta, Yasuhiko; Washizaki, M.

doi:10.1254/fpj.72.139

Cited by 8 publications

(5 citation statements)

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“…42 The FA exposure (128 to 144 µg/kg of body weight) of the dogs in the current study, however, was much lower than the effective dose reported in rats. 42 In another study 5 of dogs, a dose of 10 to 30 mg of FA/kg of body weight administered IV depressed cardiac function and reduced peripheral vascular resistance. Furthermore, the FA exposure of the dogs fed the control diet in the present study was similar to the exposures associated with the 2 contaminated diets.…”

Section: Discussionmentioning

confidence: 98%

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Effects of foodborne Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on food intake and nutrient digestibility, body weight, and physical and clinicopathologic variables of mature dogs

Leung¹,

Smith²,

Karrow³

et al. 2007

ajvr

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Section: Discussionmentioning

confidence: 98%

“…4 Fusaric acid affects brain neurotransmitter concentrations and causes vomiting, lethargy, and hypotension. [5][6][7][8] Although acute aflatoxicosis in dogs is frequently reported and studied, 9,10 little research appears to have been devoted to Fusarium mycotoxicoses in dogs.…”

mentioning

confidence: 99%

Effects of foodborne Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on food intake and nutrient digestibility, body weight, and physical and clinicopathologic variables of mature dogs

Leung¹,

Smith²,

Karrow³

et al. 2007

ajvr

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“…A major stumbling block to this conclusion is to suggest that one toxin is a cause-all agent, which is clearly a naive over simplification. Even if ICC is a simple damaged-heart effect that affects other major organs, other mycotoxins may play a role, such as moniliformin (Fan and Sun 1991;Thiel 1978), fusaric acid (Furuta and Washizaki 1976) and trichothecenes such as T-2 toxin (Wilson et al 1982), plus other disease-causing factors such as smoking and alcohol consumption. The synergist action of mycotoxins acting together is only just being realised.…”

Section: Fb1 As a General Underlying Disease Factor In Maizementioning

confidence: 99%

The African Fusarium/maize disease

Dutton

2009

Mycotox Res

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There is a general but rather vague feeling that the use of maize (corn) as a staple foodstuff by black rural Africans is somehow a factor in, or is linked to, chronic disease found in these populations. An attempt is made in this review to consider the evidence for this connection and to identify what is actually the root of the problem. The main thrust of the argument to explain this perception is that maize is routinely contaminated with fungi and of these Fusarium verticillioides is found in maize throughout the world. Evidence is presented to this effect and, further, of the mycotoxins found in maize, the fumonisins are the most common and at the highest levels. Various animal chronic diseases arising from the consumption of contaminated maize are reviewed and possible human conditions listed, in some cases related to the known animal ones. A brief overview of the complicated cellular mechanisms of fumonisin B1 is given and it is concluded that the prime suspect in what might be called "the maize disease" can be attributed to the ingestion of this mycotoxin, sometimes in combination with other synergist mycotoxins and other disease factors, such as smoking and drinking.

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“…23 FA, which is known for its powerful phytotoxicity, can accelerate the development of symptoms, such as internerval necrosis and foliar desiccation. 24 Studies have demonstrated that FA has many pharmacological activities; e.g., (i) it is used as an antihypertensive 25,26 and anticancer 27 drug; (ii) it is used in the treatment of Parkinson's disease; 28 and (iii) it is an important insect phenoloxidase inhibitor and has a positive insecticidal effect. 29,30 In our previous study, FA was reported to demonstrate considerable antifungal effects after treating 14 pathogens with FA, such as Colletotrichum higginsianum (EC 50 = 31.7 μg/mL), Thanatephorus cucumeris (EC 50 = 22.4 μg/mL), and Colletotrichum gloeosporioides (EC 50 = 90.8 μg/mL).…”

Section: ■ Introductionmentioning

confidence: 99%

Design, Synthesis, Structure–Activity Relationship, and Three-Dimensional Quantitative Structure–Activity Relationship of Fusarium Acid Derivatives and Analogues as Potential Fungicides

Huang,

Gao,

et al. 2023

J. Agric. Food Chem.

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In research related to fungicides, the development of compounds from natural products with high antifungal activity has attracted considerable attention. Fusaric acid (FA), an alkaloid isolated from the metabolites of Fusarium oxysporum, is an important precursor for developing pharmacologically active herbicides. In our previous work, we reported that FA has a wide range of inhibitory activities against 14 plant pathogenic fungi. In particular, it exhibited excellent antifugal effects on Colletotrichum higginsianum (EC 50 = 31.7 μg/mL). Herein, to explore the practical application in the agricultural field, the design and synthesis of three series of FA derivatives and their inhibitory activities against plant pathogenic fungi were examined. Results demonstrated that the optimized FA derivatives had excellent inhibitory activities against C. higginsianum, Helminthosporium (Harpophora maydis), and Pyricularia grisea. In particular, the inhibitory activities were considerably improved when the 5-butyl groups of FA were substituted. The EC 50 of C. higginsianum and P. grisea was only 1.2 and 12.0 μg/mL when 5-butylalkyl groups were substituted with 5-([1,1′biphenyl]-4-yl) and 5-phenyl, respectively. Moreover, the safety index of target compounds, which was obtained from the treatment index of medicines, on rice seeds was evaluated. Finally, 16 leading compounds (H4, H22−H24, H27, H29, H30−H34, H37, H45, H50, H52, and H53) were obtained; they had considerable potential for additional modification and optimization as agricultural fungicides. Moreover, three-dimensional quantitative structure−activity relationship models were developed for obtaining a systematic structure−activity relationship profile to explore the possibility of more potent FA derivatives as novel fungicides.

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Effects of fusaric acid and its derivative on the cardiovascular system

Cited by 8 publications

References 0 publications

Effects of foodborne Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on food intake and nutrient digestibility, body weight, and physical and clinicopathologic variables of mature dogs

Effects of foodborne Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on food intake and nutrient digestibility, body weight, and physical and clinicopathologic variables of mature dogs

The African Fusarium/maize disease

Design, Synthesis, Structure–Activity Relationship, and Three-Dimensional Quantitative Structure–Activity Relationship of Fusarium Acid Derivatives and Analogues as Potential Fungicides

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