Effects of Fungal Polysaccharide on Oxidative Damage and TLR4 Pathway to the Central Immune Organs in Cadmium Intoxication in Chickens

Li, Ruyue; Zhang, Linan; Tang, Zequn; Li, Tianqi; Li, Guangxing; Zhang, Ruili; Ge, Ming

doi:10.1007/s12011-018-1627-0

Cited by 25 publications

(18 citation statements)

References 16 publications

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“…Polysaccharides, as one of the most important active components in fungi, are long-chain carbohydrates formed by complex polymerization of various neutral sugars or uronic acids through glycosidic bonds ( Liang et al, 2021 , Vu et al, 2013 , Xin et al, 2012 ). At present, fungal polysaccharides, as a natural active ingredients, have been extensively used in cosmetic, food, and health product industries ( Li et al, 2020 , Zhao et al, 2019 ). In addition, previous scientific studies have introduced numerous discoveries, indicating that fungal polysaccharides have various biological activities, such as, immunomodulatory, antioxidant, anti-tumor, hepatoprotective, anti-inflammatory, anti-aging, hypolipidemic, and radioprotective activities ( Fan et al, 2014 , Hoang et al, 2015 , Wang et al, 2021a , Yang et al, 2006 , Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

Wang

Tan²,

Nima³

et al. 2022

Food Chemistry: X

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Section: Introductionmentioning

confidence: 99%

Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

Wang

Tan²,

Nima³

et al. 2022

Food Chemistry: X

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“…It is well documented that heavy metals can be deposited in and cause damage to immune organs. 9,36,37 Hg is a persistent environmental and industrial pollutant that causes mainly oxidative stress and inflammatory damage to target organs. Se has been shown to regulate a variety of physiological and pathological processes in immune organs, including anti-oxidant and anti-inflammatory functions.…”

Section: Discussionmentioning

confidence: 99%

“…It is well documented that heavy metals can be deposited in and cause damage to immune organs 9,36,37 . Hg is a persistent environmental and industrial pollutant that causes mainly oxidative stress and inflammatory damage to target organs.…”

Section: Discussionmentioning

confidence: 99%

Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA‐183/135b‐FOXO1/TXNIP/NLRP3 inflammasome axis

Gao

Chen

Chu

et al. 2022

Environmental Toxicology

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Mercury (Hg) is a persistent environmental and industrial pollutant that accumulated in the body and induces oxidative stress and inflammation damage. Selenium (Se) has been reported to antagonize immune organs damage caused by heavy metals. Here, we aimed to investigate the prevent effect of Se on mercuric chloride (HgCl 2 )-induced thymus and bursa of Fabricius (BF) damage in chickens. The results showed that HgCl 2 caused immunosuppression by reducing the relative weight, cortical area of the thymus and BF, and the number of peripheral blood lymphocytes. Meanwhile, HgCl 2 induced oxidative stress and imbalance in cytokines expression in the thymus and BF. Further, we found that thioredoxin-interacting protein (TXNIP) and the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome mediated HgCl 2 -induced oxidative stress and inflammation. Mechanically, the targeting and inhibitory effect of microRNA (miR)-135b/183 on forkhead box O1 (FOXO1) were an upstream event for HgCl 2 -activated TXNIP/NLRP3 inflammasome pathway. Most importantly, Se effectively attenuated the aforementioned damage in the thymus and BF caused by HgCl 2 and inhibited the TXNIP/NLRP3 inflammasome pathway by reversing the expression of FOXO1 through inhibiting miR-135b/183. In conclusion, the miR-135b/183-FOXO1/TXNIP/NLRP3 inflammasome axis might be a novel mechanism for Se to antagonize HgCl 2 -induced oxidative stress and inflammation in the central immune organs of chickens. K E Y W O R D S central immune organ, FOXO1/TXNIP/NLRP3 inflammasome, mercuric chloride, microRNA, selenium | INTRODUCTIONMercury (Hg) is a toxic heavy metal that is not essential for life but widely distributed in the environment. A series of Hg pollution accidents, such as the Minamata incident in Japan and the contaminated wheat grain incident in Iraq, prompted the signing of the Minamata Convention to limit the use and release of Hg. 1 Due to small-scale gold mining, coal burning, and irrational use of agricultural chemicals have not been eliminated, residents and animals in some countries and regions are still threatened by the high risk of Hg exposure. 2,3 Epidemiological investigations have shown that Hg exposure could induce oxidative stress, inflammation, and dysfunction in tissues 4,5 and cells. 6 The immune organs are responsible for immune cell generation, differentiation, and settlement and are essential for innate and

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“…Depending on their chemical composition, molecular weight, conformation, glycosidic bond, degree of branching, etc. [ 3 ], fungal polysaccharides presented good nutritional values and pharmaceutical properties, such as immunomodulatory [ 4 – 6 ], antitumor [ 7 – 9 ], antioxidant [ 10 ], hypocholesterolemic [ 11 , 12 ], hepatoprotective [ 13 ], and anti-inflammatory activities [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory and Antioxidant Effects of Polysaccharides from the Parasitic FungusCordyceps kyushuensis

Sun

Jian

et al. 2020

BioMed Research International

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The ascomycete Cordyceps genus has been used as valued traditional Chinese medicine. Cordyceps kyushuensis is a unique species of Cordyceps, which parasitizes on the larvae of Clanis bilineata Walker, and its major component cordycepin and aqueous extract are known to have many pharmacological effects. However, the physiological function of water-soluble polysaccharides has not been explored in detail. In this study, to resolve these doubts, we extracted and separated Cordyceps-derived polysaccharides and then evaluated the immunomodulatory and antioxidant activities. Four polysaccharide fractions were purified from Cordyceps-cultured stroma by DEAE-cellulose 23 and Sephadex G-150 column chromatography. Basic structural information was elucidated on the basis of physicochemical property and spectroscopic evidences. The antioxidant activities were evaluated by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical method and protective effect of DNA damage. The qualified immunologic activities were also determined in vivo and in vitro. The polysaccharides could stimulate the proliferation of mouse splenocytes whether concanavalin A (ConA) and lipopolysaccharide (LPS) existed or not, strengthen peritoneal macrophages to devour neutral red, and increase the content of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) in serum. The research provides the corresponding evidence for Cordyceps polysaccharides as a potential candidate for functional foods and therapeutic agents.

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Effects of Fungal Polysaccharide on Oxidative Damage and TLR4 Pathway to the Central Immune Organs in Cadmium Intoxication in Chickens

Cited by 25 publications

References 16 publications

Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA‐183/135b‐FOXO1/TXNIP/NLRP3 inflammasome axis

Immunomodulatory and Antioxidant Effects of Polysaccharides from the Parasitic FungusCordyceps kyushuensis

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