Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

Wang, Wenli; Tan, Jiaqi; Nima, Lamu; Sang, Yumei; Cai, Xu; Xue, Huang

doi:10.1016/j.fochx.2022.100414

Cited by 53 publications

(35 citation statements)

References 153 publications

(179 reference statements)

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“…The subsequent yield rate was 20.96% (the ratio of crude polysaccharide weight to the weight of powder of the L. decastes fruiting body). The extraction rate is higher than that of Pleurotus ostreatus polysaccharides and agaric polysaccharides, and similar to that of Ganoderma lucidum polysaccharides (Wang et al, 2022).…”

Section: Methylation Analysis Of Ldp-wsupporting

confidence: 54%

Structural characterization of a polysaccharide from Lyophyllum decastes with MAPK-mediated immune regulation ability in mice

WANG

2023

Food Sci. Technol

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Lyophyllum decastes is a common macrofungi for both medicinal and economic value, and its polysaccharide has excellent development potential as a new immune regulator. In the present study, the bioactive component polysaccharide of L decastes was extracted, and its chain structure was characterized in detail by Fourier transform infrared (FT-IR) spectroscopy, high-performance gel-permeation chromatography (HP-GPC), and gas chromatography-mass spectrometry (GC-MS). LDP-W had a molecular weight of 2.12 × 10 4 Da, highly branched β type pyranose. At the same time, it exhibited potential immunomodulatory activity, which can modulate the numbers of CD3+, CD4+, CD8+ and CD19+ cells in the spleen; optimize the CD4+/CD8+ ratio; promoted T and B lymphocyte proliferation and it can elevate the levels of IL-2, IL-6, IFN-γ and TNF-α in immunosuppressed mice by influencing the phosphorylation of MAPK signaling-related proteins. These studies fill the gap in the immune regulation mechanism of L decastes polysaccharide, providing a theoretical basis for the potential application of LDP-W as immunomodulatory drugs or functional foods.

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Section: Methylation Analysis Of Ldp-wsupporting

confidence: 54%

Structural characterization of a polysaccharide from Lyophyllum decastes with MAPK-mediated immune regulation ability in mice

WANG

2023

Food Sci. Technol

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“…Anion exchange column chromatography is suitable for the separation of neutral and acidic polysaccharides by eluting with different ionic strength buffers [Yu et al, 2017]. Because of the open framework and weak adsorption to polysaccharide, DEAE-cellulose was usually the first choice as an anion exchanger [Wang et al, 2022]. In the present study, GP was fractionated into three fractions, GP1, GP2 and GP3 on a DEAE-52 anion exchange column chromatograph, as shown in Figure 2A.…”

Section: Resultsmentioning

confidence: 95%

Purification and Characterization of a Low Molecular Weight Neutral Non-Starch Polysaccharide from <i>Panax ginsen</i>g by Enzymatic Hydrolysis

Ying¹,

Ma²,

Zhang³

et al. 2023

Pol. J. Food Nutr. Sci.

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In this study, a novel neutral non-starch polysaccharide (GP1A) was extracted using hot water from ginseng roots. Chemical characteristics, monosaccharide compositions and structure of GP1A were investigated using scanning electron microscopy, gel permeation chromatography, X-ray diffraction, Fourier transform infrared spectroscopy, gas chromatography with mass spectrometer, one-dimensional and two-dimensional nuclear magnetic resonance. The results indicated that the lyophilized GP1A was a homogeneous polysaccharide with a low molecular weight of 1.03 kDa. The dominating monosaccharides of GP1A were d-glucose, d-galactose, d-mannose, d-xylose and d-arabinose. The structure analysis indicated the main chain residues sequence of GP1A was α-d-Glcp-(6→3)-α-d-Galp-(1→1)-α-d-Glcp-(3→4)-β-d-Manp-(2→2)-β-d-Arap with branch chains of α-d-Glcp substituted at α-d-Galp and β-d-Xylp substituted at β-d-Manp.

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“…In addition, GLP could also regulate the tumor microenvironment, inhibit the growth of tumor cells, and increase the rate of apoptosis. [75] G. lucidum water-soluble polysaccharides could inhibit the proliferation of human breast cancer cells and induce tumor cell apoptosis through the loss of mitochondrial membrane potential, the accumulation of ROS and the expression levels of apoptosis related proteins. [76] Liu et al [6] found that Russula griseocarnosa polysaccharides could increase the production of lactate dehydrogenase and ROS, significantly reduce the viability of tumor cells, and promote the apoptosis of human cervical cancer cells (HeLa and SiHa), indicating that R. griseocarnosa polysaccharides can be developed into a tumor inhibitor for tumor prevention and treatment.…”

Section: Anti-tumor Activitymentioning

confidence: 99%

Research Progress on Biological Activities of Polysaccharides from Edible Fungus

et al. 2023

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Edible fungus is widely eaten because of their delicious taste and high nutritional value. Growing evidence indicates that edible fungus is rich in various active ingredients including polysaccharides, proteins, fats, vitamins, and other ingredients. Polysaccharides are one of the main active ingredients of edible fungi. Increasing research has confirmed that edible fungus polysaccharides (EFPs) show multiple biological activities such as antioxidant, anti-inflammatory, anti-tumor, immune regulation, anti-virus, gut microbiota regulation, hypoglycemic, etc. Hence, EFP related research has received more and more attention due to their non-toxic, high medical, and nutritional values. This paper reviews the latest research progress of EFPs biological activities, and looks forward to their future development trend. This review provides a theoretical basis for studying the application of EFPs in the fields of biomedicine, cosmetics, health food, and promotes the development and utilization of EFPs.

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Polysaccharides from fungi: A review on their extraction, purification, structural features, and biological activities

Cited by 53 publications

References 153 publications

Structural characterization of a polysaccharide from Lyophyllum decastes with MAPK-mediated immune regulation ability in mice

Structural characterization of a polysaccharide from Lyophyllum decastes with MAPK-mediated immune regulation ability in mice

Purification and Characterization of a Low Molecular Weight Neutral Non-Starch Polysaccharide from <i>Panax ginsen</i>g by Enzymatic Hydrolysis

Research Progress on Biological Activities of Polysaccharides from Edible Fungus

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