Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans

Lecoultre, Virgile; Egli, Léonie; Carrel, Guillaume; Theytaz, Fanny; Kreis, Roland; Schneiter, Philippe; Boss, Andreas; Zwygart, Karin; Lê, K-A.; Bortolotti, M.; Boesch, Chris; Tappy, Luc

doi:10.1002/oby.20377

Cited by 124 publications

(130 citation statements)

References 13 publications

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“…This shows that fast-food hyper alimentation affects significantly consumers' weight, BMI, SAD, waist and hip circumference, ALT, AST, ALP and basal metabolic rate. This agrees with previous observations by Rosquivist et al [17] and Lecoulture et al [18]. The bilirubin levels in the study however decreased in the intervention group from 0.75(0.15) to 0.58 (0.15).…”

Section: Resultssupporting

confidence: 93%

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Effect of Fast-Food-Based Hyper-Alimentation on Liver Enzymes In Healthy Nigerian Youths

Oyedepo¹,

Sodamade²,

Odefunso³

2016

IOSR

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Fast-food 64.2 (8.9) kg (p<0.001). Serum Alanine transferase (ALT) increased from 20.4 (9.5) U/l at the beginning of the study to a maximum level of 58.5 (12) U/l (normal range 7 -56 U/l). Aspartate Aminotransferase (AST) increased from 28.7 (14) U/l to 41.2 (20) U/l (normal range 5 -40 U/l) while Alkaline Phosphatase (ALP) also increased from 35.6 (13) U/l to 66.5 (14)U/l [normal range: 25 -100U/l]. It was however observed that serum aminotransferases levels, ALP and body weight were not significantly altered in the control subjects. The results of this study is therefore an indication that fast-food hyper-alimentation can trigger the elevation of liver marker enzymes which is an indication for the onset of fatty liver diseases.

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Section: Resultssupporting

confidence: 93%

“…With thirty-nine adults fed muffins with extra SFAs for seven weeks they markedly increased liver fat. Lecoulture et al [12] opined that short-term overfeeding with fructose or glucose decreases hepatic insulin sensitivity and increases hepatic fat content.…”

Section: Introductionmentioning

confidence: 99%

Effect of Fast-Food-Based Hyper-Alimentation on Liver Enzymes In Healthy Nigerian Youths

Oyedepo¹,

Sodamade²,

Odefunso³

2016

IOSR

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“…In the 6 studies in adults, liver fat was examined in 5, 34,37,38,40,41 VAT in 2, 40,41 and muscle fat in 4. 34,37,38,40 Five of the 6 studies compared high-fructose diets with high-glucose diets, 34,[38][39][40][41] …”

Section: Comparison Of the Effects Of Different Sources Or Types Of Amentioning

confidence: 99%

Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

Karlsen

Chung

et al. 2015

Nutr Rev

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Context: The effect of added sugar intake on ectopic fat accumulation is a subject of debate. Objective: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to examine the potential effect of added sugar intake on ectopic fat depots. Data Sources: MEDLINE, CAB Abstracts, CAB Global Health, and EBM (Evidence-Based Medicine) Reviews -Cochrane Central Register of Controlled Trials databases were searched for studies published from 1973 to September 2014. Data Extraction: RCTs with a minimum of 6 days' duration of added sugar exposure in the intervention group were selected. The dosage of added sugar intake as a percentage of total energy was extracted or calculated. Means and standard deviations of pre-and post-test measurements or changes in ectopic fat depots were collected. Data Synthesis: Fourteen RCTs were included. Most of the studies had a medium to high risk of bias. Meta-analysis showed that, compared with eucaloric controls, subjects who consumed added sugar under hypercaloric conditions likely increased ectopic fat, particularly in the liver (pooled standardized mean difference ¼ 0.9 [95%CI, 0.6-1.2], n ¼ 6) and muscles (pooled SMD ¼ 0.6 [95%CI, 0.2-1.0], n ¼ 4). No significant difference was observed in liver fat, visceral adipose tissue, or muscle fat when isocaloric intakes of different sources of added sugars were compared. Conclusions: Data from a limited number of RCTs suggest that excess added sugar intake under hypercaloric diet conditions likely increases ectopic fat depots, particularly in the liver and in muscle fat. There are insufficient data to compare the effect of different sources of added sugars on ectopic fat deposition or to compare intake of added sugar with intakes of other macronutrients. Future well-designed RCTs with sufficient power and duration are needed to address the role of sugars on ectopic fat deposition.

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“…This result could be explained by the fact that the carbohydrate (glucose, sucrose, fructose) rich diet contributes in increasing blood glucose hence causing hyperglycemia [16,17,18]. Blood glucose was reduced significantly in rats supplemented with To and it was maintained within normal values in those supplemented with both plants.…”

Section: Discussionmentioning

confidence: 99%

Effect of Combined Dietary Supplementation of Telfairia Occidentalis Leaves and Citrulus Colocynthis Seeds on Fasting Glycemia, Glucose Tolerance and Body Weight in Wistar Rats

Bc¹,

Cl²,

Cj³

et al. 2017

J Nutr Disorders Ther

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Though medical assistance can be given to diabetic patients, dietary care is highly explored. This work aimed at studying the effects of dietary supplementation of uncooked Telfairia occidentalis leaves combined with Citrulus colocynthis seeds on blood glucose level in Wistar rats. A phytochemical screening was realized on T.occidentalis ethanolic and hydroethanolic leaves extracts, and their acute toxicity was studied in rats. The effect of their combined dietary supplementation on glycemia and body weight was studied in rats receiving carbohydrate enriched diet during 28 days. Three test groups received 10% Telfairia occidentalis leaves, 10% C.colocynthis and a mixture of 5% T.occidentalis leaves and 5% C. colocynthis respectively. Glibenclamide (0.03 mg/kg b.w) was used as reference drug.Glucose tolerance was tested at the end of supplementation period. The presence of tannins, saponins, anthocyanines and flavonoids was revealed in T. occidentalis extracts and no sign of toxicity was identified in rats. Fasting glycemia decreased significantly in rats supplemented with T. occidentalis as compared to positive control and there was no significant increase in glycemia for rats supplemented with C. colocynthis and with both plants. All animals except the positive control showed a good glucose tolerance at the end of supplementation. T. occidentalis showed hypoglycemic properties and its association with C. colocynthis inhibited hyperglycemia and maintained good glucose tolerance. Hence, combined consumption of T. occidentalis leaves with C. colocynthis seeds might be advised in diabetes management.

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Effects of fructose and glucose overfeeding on hepatic insulin sensitivity and intrahepatic lipids in healthy humans

Cited by 124 publications

References 13 publications

Effect of Fast-Food-Based Hyper-Alimentation on Liver Enzymes In Healthy Nigerian Youths

Effect of Fast-Food-Based Hyper-Alimentation on Liver Enzymes In Healthy Nigerian Youths

Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

Effect of Combined Dietary Supplementation of Telfairia Occidentalis Leaves and Citrulus Colocynthis Seeds on Fasting Glycemia, Glucose Tolerance and Body Weight in Wistar Rats

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