Effects of Four Si-Wu-Tang's Constituents and Their Combination on Irradiated Mice

Ferulic acid induces heme oxygenase-1 <i>via</i> activation of ERK and Nrf2

“…A previous report by the current authors showed FA was a nontoxic and effective radioprotectant in animal studies (16). FA has been found to protect lymphocytes from radiation-induced early damage (17), and this effect may be mediated by scavenging ROS (18).…”

Effects of ferulic acid on hematopoietic cell recovery in whole-body gamma irradiated mice

“…It would be advantageous to find a new drug with the character of high efficacy and low toxicity. Our previous study showed FA could protect against radiation-induced hematopoietic damage (Liang et al 2006). To test whether FA could accelerate blood cell recovery, we examined the effects of FA on hematopoietic recovery from 2.5 Gy total body radiation, and the results showed FA could accelerate blood cells recovery.…”

“…Our previous study showed FA could protect human umbilical vein endothelial cells from radiation-induced oxidative stress by phosphatidylinositol 3-kinase and extracellular regulated kinase (ERK) pathways (Ma et al 2010a). FA has been demonstrated to be a non-toxic and effective radioprotectant in animal studies (Liang et al 2006). However, the detailed mechanism of FA in the protection against radiation-induced hematopoietic damage needs to be clarified.…”

Ferulic Acid Attenuates Adhesion Molecule Expression in Gamma-Radiated Human Umbilical Vascular Endothelial Cells

“…7) It effectively scavenges superoxide anion radical and inhibits the lipid peroxidation because of its strong antioxidant activity. 8) FA, an effective radioprotector during radiotherapy, stimulates hematopoiesis, immunity and DNA repair in irradiated mice.…”