Effects of forsythoside on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages

Guan, Jianguo; Shen, Hong; Zhang, Yonghong; Cui, Defeng

doi:10.5897/ajpp2013.3584

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…FTA significantly downregulated the expression of TRPV1 in hypothalamus and DRG of the yeast-induced fever mice, inhibited MAPKs activation of the hypothalamus and DRG, and then decreased secretion ofPGE2 ( Liu et al, 2017a ). Recent studies have shown that forsythoside can significantly reduce TNF-α secretion in LPS-stimulated RAW 264.7 cells, suggesting that it can reduce TNF-α secretion to relieve fever ( Guan et al, 2013 ). FTA can also suppress LPS-mediated induction of the TLR4 pathway.…”

Section: Single Chinese Herbal Medicines In the Treatment Of Fevermentioning

confidence: 99%

Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation

Liu

Luo

et al. 2021

Front. Pharmacol.

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The coronavirus disease, 2019 (COVID-19), has spread rapidly around the world and become a major public health problem facing the world. Traditional Chinese medicine (TCM) has been fully committed to treat COVID-19 in China. It improved the clinical symptoms of patients and reduced the mortality rate. In light of the fever was identified as one of leading clinical features of COVID-19, this paper will first analyze the material basis of fever, including pyrogenic cytokines and a variety of the mediators of fever. Then the humoral and neural pathways of fever signal transmission will be described. The scattered evidences about fever recorded in recent years are connected in series. On this basis, the understanding of fever is further deepened from the aspects of pathology and physiology. Finally, combining with the chemical composition and pharmacological action of available TCM, we analyzed the mechanisms of TCMs to play the antipyretic effect through multiple ways. So as to further provide the basis for the research of antipyretic compound preparations of TCMs and explore the potential medicines for the prevention and treatment of COVID-19.

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Section: Single Chinese Herbal Medicines In the Treatment Of Fevermentioning

confidence: 99%

Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation

Liu

Luo

et al. 2021

Front. Pharmacol.

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show abstract

“…TRPV1 is a non-selective cation channel gated by noxious heat, playing major roles in thermoregulation. FT-A alleviated fever of yeast-induced pyrexia mice via suppression of TRPV1 expression and activation, inhibition of MAPKs, activation of the hypothalamus and DRG, and subsequently decreased secretion of pyretic cytokine as PGE2 and IL-8 ( Liu et al., 2017 ).In addition, FT-A can significantly enhance the phagocytic function of macrophages in LPS-stimulated ra-w264.7 cells and reduce the secretion of TNF-α ( Guan et al., 2013 ). FT-A can also inhibit TNF-α and NF-κB by blocking the LPS/TLR4 signaling pathway ( Zeng et al., 2017 ).…”

Section: Fevermentioning

confidence: 99%

Research Progress on Main Symptoms of Novel Coronavirus Pneumonia Improved by Traditional Chinese Medicine

Luo

Liu

et al. 2020

Front. Pharmacol.

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Novel coronavirus (COVID-19) pneumonia has become a major threat to worldwide public health, having rapidly spread to more than 180 countries and infecting over 1.6 billion people. Fever, cough, and fatigue are the most common initial symptoms of COVID-19, while some patients experience diarrhea rather than fever in the early stage. Many herbal medicine and Chinese patent medicine can significantly improve these symptoms, cure the patients experiencing a mild 22form of the illness, reduce the rate of transition from mild to severe disease, and reduce mortality. Therefore, this paper summarizes the physiopathological mechanisms of fever, cough, fatigue and diarrhea, and introduces Chinese herbal medicines (Ephedrae Herba, Gypsum Fibrosum, Glycyrrhizae Radix et Rhizoma, Asteris Radix et Rhizoma, Ginseng Radix et Rhizoma, Codonopsis Radix, Atractylodis Rhizoma, etc.) and Chinese patent medicines (Shuang-huang-lian, Ma-xinggan-shi-tang, etc.) with their corresponding therapeutic effects. Emphasis was placed on their material basis, mechanism of action, and clinical research. Most of these medicines possess the pharmacological activities of anti-inflammatory, antioxidant, antiviral, and immunity-enhancement, and may be promising medicines for the treatment or adjuvant treatment of COVID-19 patients.

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Effects of forsythoside on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages

Abstract: Forsythoside (FS) is an active component of

Cited by 2 publications

References 27 publications

Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation

Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation

Research Progress on Main Symptoms of Novel Coronavirus Pneumonia Improved by Traditional Chinese Medicine

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