Effects of food flavour enhancer (Monosodium Glutamate and Maggi Poulet) supplementation on glucose tolerance in <i>Sprague Dawley</i> rat

Abstract

This study was designed to evaluate the effects of purified monosodium glutamate and 'Maggi Poulet', on body weight gain, lipid profile, hepatic lipid peroxidation and glucose tolerance in rats. Thirty five young male Sprague Dawley rats were divided into five groups and fed by oral route as follow: group I (distilled water), group II (monosodium glutamate solution), group III ('Maggi Poulet'solution), group IV (monosodium glutamate solution. and high fat solution) and group V ('Maggi Poulet' solution and high fat solution). During the experimental period, fasting glycemia was taken and an oral glucose tolerance test has been performed at the end . Blood samples were then collected in all groups and serum cholesterol and triglyceride were assayed. Animals were killed after and abdominal adipose tissue, liver and heart were excised and weighed. Liver samples were also used to estimate hepatic malondialdehyde level in rats. The results proved that the dietary feeding did not affect the body gain and lipid profile in experimental groups. The hepatic lipid peroxidation has also increased in all experimental groups and at the same time, rats in group II, group IV and group V present a two-hour plasma glucose level signifantly higher. However, purified monosodium glutamate and 'Maggi Poulet' at the dose of 1500 mg/kg. b. wt. have not impaired fasting glycemia in Sprague Dawley rat. All changes observed in the glycemia of rats in experimental groups do not allow to qualify them to be glucose intolerant, nevertheless monosodium glutamate consumption in association or not with high fat is hepatotoxic and may contribute to the emergence of prediabetes in human being.

Effects of Administration of Bouillon Cubes on Insulin Resistance, Lipid Profile and Renal Function Parameters in Female Albino Rats

“…It leads to impaired regulation of hepatic glucose synthesis, declining beta-cell function, ultimately leading to beta-cell failure [22]. This finding agrees with Tchaou et al [23], which showed that overnight fasting glucose was not influenced by monosodium glutamate (MSG) and Maggi poulet solution injection. Another study found no effects of MSG administration on postprandial glycaemia and insulinemia [24], however, MSG-obese rats had impaired glucose tolerance and insulin resistance [25].…”

Reproductive & Biomarker Response to a Daily Dose of Instant Noodle Seasoning in Male Albino Rats (Rattus norvegicus)

“…The liver damaging ability or hepatotoxic property of MSG found in instant noodle seasoning have been reported by many authors. A study conducted by Tchaou et al [33] showed that MSG consumption is hepatotoxic, and another work done by Diniz et al [34] found out that administration of MSG was associated with oxidative stress in hepatic tissues. The result was also in agreement with the work of Bopanna et al [7] who observed adverse effect on the liver of rats fed with food contaminated with monosodium.…”