Effects of fluvoxamine and dothiepin on psychomotor abilities in healthy volunteers

Fairweather, D. B.; Ashford, J.J.; Hindmarch, Ian

doi:10.1016/0091-3057(95)00210-3

Cited by 30 publications

(15 citation statements)

References 16 publications

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“…Dothiepin was found to cause a significant reduction in overall daytime activity compared with placebo and both doses of fluvoxamine. The actigraphy results were found to be in agreement with that from the psychometric test performed on the study and reported elsewhere (Fairweather et al, 1996) which showed dothiepin caused significant impairment on both objective and subjective measures.…”

Section: The Measurement Of Daytime Sedationsupporting

confidence: 89%

Actigraphy in human psychopharmacology: a review

Stanley

2003

Human Psychopharmacology

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Over the last 25 years wrist actigraphy has predominantly been used in sleep research and chronobiology where the technique has proved useful in the measurement of sleep and the characterisation of the sleep/wake cycle. Whilst there are a large number of studies published that have used actigraphy, there have only been relatively few studies that have shown that the technique is capable of measuring drug-induced changes in nocturnal and/or diurnal behaviour. Thus the use of actigraphy to measure drug effects in clinical trials has up till now remained on the periphery of psychopharmacology. However this may be because of the disparate nature of the studies published rather than lack of usefulness. This paper reviews the relevant literature and in doing so concludes that there is a convincing body of evidence for the utility of actigraphy as a technique in human psychopharmacology.

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Section: The Measurement Of Daytime Sedationsupporting

confidence: 89%

Actigraphy in human psychopharmacology: a review

Stanley

2003

Human Psychopharmacology

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“…Previous research has assessed the effect of drugs on actigraphic sleep and daytime behaviour in small scale studies including sedatives [18,19], antidepressants [13,20,21], hypnotics [22,23], antihistamines [24][25][26] and stimulants [27]. The classes of drugs which are prescribed for inducing sleep, reducing anxiety or reducing a histaminic response have well documented side effects including reduction in activity during wake [22,23] and impairment of mental ability and alertness in the acute phase following drug administration [28,29].…”

Section: Introductionmentioning

confidence: 99%

“…Currently the evaluation of psychotropic drug effects has been conducted utilising psychometric test batteries to assess daytime cognition and psychomotor functioning [12][13][14] whilst night-time sleep has been evaluated with PSG to assess changes in sleep architecture. This design is possible in Phase I and II studies but the data are limited to a relatively small number of volunteers and may not be relevant to the general population and in particular to the patient groups intended to receive the medication.…”

Section: Introductionmentioning

confidence: 99%

Benzodiazepine‐induced reduction in activity mirrors decrements in cognitive and psychomotor performance

Dawson

Boyle

Stanley

et al. 2008

Human Psychopharmacology

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What this paper addsWhat is already knownThe evaluation of psychotropic drug effects has been conducted utilising psychometric test batteries to assess changes in daytime cognition and psychomotor functioning and PSG to assess changes in sleep. Actigraphy is widely accepted as a non-invasive tool for assessing sleep-wake patterns in different groups. However, there is limited data to show that actigraphy can reliably measure the daytime and night-time characteristics of a CNS drug. What this study adds -This study provides further evidence that actigraphy is sensitive not only to the sedating effects of a hypnotic drug but also to the hangover effects of the drug the following morning. It confirms that the actiwatch is able to detect the effects of a hypnotic on actigraphically measured sleep. Further evidence that actigraphy can provide a reliable and sensitive indication of the time course of action of psychoactive drugs. Lorazepam-induced reduction in activity 3 ABSTRACTAim: To assess whether actigraphy is sensitive to lorazepam-induced changes in cognitive and psychomotor performance by measuring activity levels following placebo and lorazepam (LZP) dosing.Methods: Healthy volunteers were randomised to a double-blind, placebocontrolled, crossover trial. Activity was recorded by actigraphy throughout each test period and pooled into 30 min bins for analysis. Following LZP dosing (2.5 mg at 18.00 h) psychomotor and cognitive tests were conducted at regular intervals.Results: Activity levels were significantly reduced between the psychometric tests (P < 0.02) at 2, 3 and 5 h post dose and during the psychometric tests (P < 0.02) at 2.5 and 4.5 h post dose. Subjects only felt sedated (P < 0.01) at 4.5 h post dose. Activity levels were also significantly reduced (P < 0.05) during sleep (23:00-07:00 h), and the following morning, activity levels remaining suppressed (P < 0.02) at 13.5 and 14 h post dose. Cognitive and psychomotor performance reflected changes in activity levels with significant impairment (P < 0.05) at 2.5, 3.5, 4.5 and 14.5 h post dose.Conclusion: This study showed that actigraphic activity levels were significantly reduced following LZP dosing. These changes were mirrored by impairment of cognitive and psychomotor performance. Actigraphy is therefore sensitive to the sedating effect of LZP and appears able to detect changes in sleep behaviour (hypnotic efficacy) and residual effects the following morning. Actigraphy may thus be a useful tool in assessing the psychopharmacology of CNS medication. Lorazepam-induced reduction in activity4

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“…Fairweather et al 1996Fairweather et al , 1997Hindmarch 1988). Indeed, there is evidence to suggest that SSRIs may actually facilitate psychomotor function (e.g.…”

Section: Introductionmentioning

confidence: 96%