Effects of flavonoids on the release of reactive oxygen species by stimulated human neutrophils

Development and Investigation of Dry Powder Inhalers for Cystic Fibrosis

“…Among natural flavonoids, naringin (N, Fig. 1) extracted from grapefruits has shown anti-inflammatory, antioxidant and anticarcinogenic effects [18]. In addition, recent studies have reported that flavonoids may act as CFTR direct activators, stimulating transepithelial chloride transport [19][20][21].…”

Epidemiological evidence on potential health properties of flavonoids

“…Their polyphenolic structure makes flavonoids potent radical scavengers and metal chelators. Their antioxidant activities have been repeatedly investigated and reviewed (Takahama, 1985;Limasset et al 1993).…”

The Effect of Ginkgo Biloba Extract on Free Radical Production in Hypoxic Rats.

“…Many studies have shown that the number of hydroxyl groups on the B-ring of flavonoids plays a key role important in radical scavenging activity, and that two hydroxyl groups on the phenyl ring are optimal for such an effect, 16) and that this potency is generally decreased by C2-C3 saturation and glycosylation. 17) Recent studies suggested that nitric oxide synthase activity contributed to luminol-dependant CL response of human neutrophils while administration of free Cu-Zn SOD did not affect it. 18,19) As for possible drug action on antioxidant enzyme activities (Cu-Zn SOD-GSH Px), no statistically significant differences were observed between normoxic, control and treated rats at both drug doses used.…”