Effects of Ficus carica paste on loperamide-induced constipation in rats

Lee, Hak-Yong; Kim, Jung-Hoon; Jeung, Han-Wool; Lee, Cha-Uk; Kim, Do‐Sung; Li, Bo; Lee, Geum-Hwa; Sung, Myung‐Soon; Ha, Ki-Chan; Back, Hyang‐Im; Kim, Sun‐Young; Park, Soo-Hyun; Oh, Mi‐Ra; Kim, Min‐Gul; Jeon, Ji‐Young; Im, Yeon-Ho; Hwang, Mina; So, Byung‐Ok; Shin, Sook-Jeong; Yoo, Wan‐Hee; Kim, Hyung‐Ryong; Chae, Han-Jung; Chae, Soo‐Wan

doi:10.1016/j.fct.2011.12.001

Cited by 91 publications

(98 citation statements)

References 35 publications

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“…The fig results are also in line with Lee et al (2012) and Fathy (2014) who found that the administration of fig extract to irradiated rats led to improvements in the lipid profile, lipid risk ratios, and hematological parameters.…”

Section: Discussionsupporting

confidence: 76%

The beneficial effect of natural antioxidants from olive oil with fig and date palm fruit extracts on biochemical and hematological parameters in rats during diethylnitrosamine-induced carcinogenesis

Fathy

Bashandy

et al. 2018

FACETS

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Diethylnitrosamine (DEN) is a well-known carcinogen. The aim of our study was to determine the role of olive oil (7 g/kg) with fig (1 g/kg) (OF) and (or) date palm (1 g/kg) (D) fruit extracts during DEN treatment of male Wistar rats. The OF-DEN and (or) D-DEN groups were given oral antioxidants daily for two weeks before and during DEN treatment (21 weeks).The DEN-treated group showed dramatic results for all investigated parameters as compared with the control rats. All OF-DEN and D-DEN groups showed significant improvement in hepatic thiobarbituric acid reactive substances, reduced glutathione, and nitric oxide concentration in the liver tissue, in addition to improvement in serum vascular endothelial growth factor level, alpha-fetoprotein, lipid profile, lipid risk ratios, and the hematological parameters as compared with the DEN-treated group.In conclusion, the administration of OF and (or) D fruit extracts to DEN-treated rats resulted in a considerable improvement in the investigated biochemical and hematological parameters. In addition, the combined OFD treatments showed greater improvements revealing the synergistic effect of the combination.

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Section: Discussionsupporting

confidence: 76%

The beneficial effect of natural antioxidants from olive oil with fig and date palm fruit extracts on biochemical and hematological parameters in rats during diethylnitrosamine-induced carcinogenesis

Fathy

Bashandy

et al. 2018

FACETS

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“…The stools and urine excreted from each SD rat were collected at 10:00 am. Stool weight was weighed three times per sample using an electric balance, whereas the water content was determined as the difference between the wet and dry weights of the stool as described previously [6,11]. Changes in the urine volume were measured three times per sample using a cylinder.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, ethanol extracts of agarwood ( Aquilaria sinensis , Aquilaria crasna ) leaves are known to increase the frequency and weight of stools, gastro-intestinal transit, and intestinal tension without induction of diarrhea as a side effect [10]. Significant increases in the number, weight, and water content of fecal pellets as well as the intestinal transit length and thickness of the distal colon have also been observed in response to Ficus carica paste treatment [11]. Various herbal medicines have recently received attention as novel therapeutic drugs for treatment of constipation.…”

Section: Introductionmentioning

confidence: 99%

Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats

Kim

Lee

Kwak

et al. 2013

BMC Complement Altern Med

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BackgroundLiriope platyphylla has long been reported as a therapeutic drug for treatment of various human chronic diseases including inflammation, diabetes, neurodegenerative disorders, obesity, and atopic dermatitis. To investigate the laxative effects of L. platyphylla, alterations in excretion parameters, histological structure, mucin secretion, and related protein levels were investigated in rats with loperamide (Lop)-induced constipation after treatment with aqueous extract of L. platyphylla (AEtLP).MethodsAlterations on constipation phenotypes were measured in rats with Lop-induced constipation after treatment with AEtLP using excretion parameter analysis, histological analysis, RT-PCR, western blot and transmission electron microscope (TEM) analysis.ResultsThe amounts of stool and urine excretion were significantly higher in the Lop + AEtLP-treated group than in the Lop + vehicle-treated group, whereas food intake and water consumption were maintained at constant levels. AEtLP treatment also induced an increase in villus length, crypt layer, and muscle thickness in the constipation model. Total mucin secretion was higher in the Lop + AEtLP-treated group than in the Lop + vehicle-treated group, although mucin secretion per crypt was very similar among all groups. Furthermore, RT-PCR and western blot revealed a dramatic reduction of key factors level on the muscarinic acetylcholine receptors (mAChRs) signaling pathway in the Lop + AEtLP-treated group relative to the Lop + vehicle-treated group. Especially, the accumulation of lipid droplets in enterocytes of crypts following Lop treatment was improved to the level of the No-treated group in response to AEtLP treatment.ConclusionThese results suggest that AEtLP improves constipation induced by Lop treatment through an increase in crypt layer and stimulation of lipid droplet secretions. These data are the first to show that the laxative effects of AEtLP are closely related to the down-regulation of mAchRs and their downstream signals.

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“…However, none of these options produce satisfactory responses (American College of Gastroenterology Chronic Constipation Task Force, 2005;Ford et al, 2014;Sanchez & Bercik, 2011). Thus, herbal plants and medicinal foods have received increasing attention as promising alternative therapeutic choices for the treatment of constipation (Lee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Character and laxative activity of polysaccharides isolated from Dendrobium officinale

Luo

Qu²,

Lin

et al. 2017

Journal of Functional Foods

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Effects of Ficus carica paste on loperamide-induced constipation in rats

Cited by 91 publications

References 35 publications

The beneficial effect of natural antioxidants from olive oil with fig and date palm fruit extracts on biochemical and hematological parameters in rats during diethylnitrosamine-induced carcinogenesis

The beneficial effect of natural antioxidants from olive oil with fig and date palm fruit extracts on biochemical and hematological parameters in rats during diethylnitrosamine-induced carcinogenesis

Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide-induced constipation of SD rats

Character and laxative activity of polysaccharides isolated from Dendrobium officinale

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