Effects of Feijining Decoction on vascular endothelial growth factor protein expression and changes of T cell subsets in Lewis lung carcinoma-bearing mice

Zhou, Lijiang; Pan, Yuzhen; Yu-qing, Xing; Gao, Hong; Xie, Xiaodong; Yin, Dengke

doi:10.3892/br.2015.432

Biomedical Reports

2015

DOI: 10.3892/br.2015.432

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Effects of Feijining Decoction on vascular endothelial growth factor protein expression and changes of T cell subsets in Lewis lung carcinoma-bearing mice

Lijiang Zhou

Yuzhen Pan

Xing Yu-qing

et al.

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Cited by 4 publications

(2 citation statements)

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“…Tumor endothelial cells differ significantly from normal endothelial cells by structural and functional characteristics that finally determine the process of angioneogenesis [22]. Changes of expression pattern of the proteins controlling angiogenesis can serve as prognostic marker of malignant process [26]. They can be used also for monitoring of anticancer treatment efficacy in LC patients [3].…”

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confidence: 99%

Endothelial Dysfunction of Vessels at Lung Cancer

Dumanskiy¹,

Stoliarova²,

Syniachenko³

et al. 2015

Exp. Onc.

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Aim: To evaluate changes in indicators of endothelial function and their relationship with morphological forms of disease, stage of pathological process and tumor markers, by analysis the peripheral blood of lung cancer (LC) patients. Materials and Methods: 38 LC patients without metastases (mean age — 57 years) prior chemo- and radiotherapy were included in the study. The duration of the disease manifestation was 18 months. 21% of patients had small cell LC, and the rest — non-small cell LC. The ratio of patients with stages IA, IB, IIA, IIB, IIIA and IIIB LC was 1 : 3 : 3 : 4 : 4 : 4. The enzyme immunoassay, spectrophotometry, and statistical data analysis were used. Results: Endothelial dysfunction of vessels was characterized by increased blood levels of vascular endothelial growth factor (VEGF), endothelin-1 (ET1), homocysteine (HCys), cyclic guanosine monophosphate (cGMP), P-selectin (PSel) and nitrites (NO2) and simultaneously by decreased values of prostacyclin (PgI2). Those were observed in 100; 90; 76; 71; 50; 53 and 79% of LC cases, respectively. Disturbances of vascular endothelial function were associated with patient’s age, disease duration, and morphological form and LC stage. Such changes were observed in women with higher prevalence. The studied indices correlated with tumor markers, namely transforming growth factor beta (TGFβ1), fibronectin and osteopontin. Conclusion: Indices of vascular endothelial dysfunction in LC can be of diagnostic and prognostic value.

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confidence: 99%

Endothelial Dysfunction of Vessels at Lung Cancer

Dumanskiy¹,

Stoliarova²,

Syniachenko³

et al. 2015

Exp. Onc.

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“…An important pathogenetic link supporting the properties of LC is neoangiogenesis (the formation of new vessels) [3]. At the same time, the expression of protein products that are surfactants (surface active substances) or possessing insurfactant properties (surface-inactive) in patients with LC provides the processes of neoangiogenesis and the physicochemical interfacial state of blood serum [4]. There is a close intercommunication between the biochemical components and the functional activity of the cells in tumor microenvironment, capable to secrete surfactants/ insurfactants influencing biochemical processes, and thus the adsorption-rheological properties of blood (ARPB) -surface tension (ST), serum viscosity (SV), serum elasticity (SE), serum relaxation (SR), and viscoelasticity (VE) modulus [5,6].…”

mentioning

confidence: 99%

Adsorption-Rheological Properties of Blood Serum in Lung Cancer Patients

Dumanskiy¹,

Stoliarova²,

Syniachenko³

et al. 2017

Exp. Onc.

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The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity).

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Recent highlights of Chinese medicine for advanced lung cancer

Han

2016

Chin. J. Integr. Med.

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Owing to its unique superiority in improving quality of life and prolonging survival time among advanced lung cancer patients, Chinese medicine (CM) has, in recent years, received increased attentions worldwide. We utilized a bibliometric statistical method based on MEDLINE/GoPubMed to conduct a comprehensive analysis of the current application status of CM in lung cancer, by including annual and accumulated publications, origin distribution of countries and journals, and keywords with a higher frequency score. Then the relevant clinical trials and mechanistic studies were systematically summarized within the field according to research types. We have raised potential problems and provided potentially useful reference information that could guide similar studies in the future. The basic experimental results are highly consistent with clinical trials, leading us to conclude that CM can offer better overall therapeutic benefits when used in combination with routine Western medicine for patients with advanced lung cancer.

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Effects of Feijining Decoction on vascular endothelial growth factor protein expression and changes of T cell subsets in Lewis lung carcinoma-bearing mice

Cited by 4 publications

References 26 publications

Endothelial Dysfunction of Vessels at Lung Cancer

Endothelial Dysfunction of Vessels at Lung Cancer

Adsorption-Rheological Properties of Blood Serum in Lung Cancer Patients

Recent highlights of Chinese medicine for advanced lung cancer

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