Effects of feeding restriction on skeletal muscle development and functional analysis of
            <i>TNNI1</i>
            in New Zealand white rabbits

Liu, Yunpeng; Zhou, Tong; Liu, Sian; Dai, Yingying; Bai, Shaocheng; Zhao, Bohao; Tang, Xianwei; Wu, Xinsheng; Chen, Yang

doi:10.1080/10495398.2022.2155662

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…The over-expression of TNNI1 significantly enhanced the expression of the skeletal muscle development-related genes in New Zealand white rabbits, and the silencing of TNNI1 gene significantly reduced expression of these genes. It revealed that TNNI1 may be a regulator for regulating the expression of muscle development-related genes [22]. In cold-exposed Altay lambs, the gene expressions of PVALB, TNNC1, MYL2, and ACTC1 related to muscle contraction were higher in muscle tissue of Altay than Hu lambs [23].…”

Section: Discussionmentioning

confidence: 98%

Transcriptomic and metabolomic dissection of skeletal muscle of crossbred Chongming white goats with different meat production performance

Lin,

Sun,

et al. 2024

BMC Genomics

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Background The transcriptome and metabolome dissection of the skeletal muscle of high- and low- growing individuals from a crossbred population of the indigenous Chongming white goat and the Boer goat were performed to discover the potential functional differentially expressed genes (DEGs) and differential expression metabolites (DEMs). Results A total of 2812 DEGs were detected in 6 groups at three time stages (3,6,12 Month) in skeletal muscle using the RNA-seq method. A DEGs set containing seven muscle function related genes (TNNT1, TNNC1, TNNI1, MYBPC2, MYL2, MHY7, and CSRP3) was discovered, and their expression tended to increase as goat muscle development progressed. Seven DEGs (TNNT1, FABP3, TPM3, DES, PPP1R27, RCAN1, LMOD2) in the skeletal muscle of goats in the fast-growing and slow-growing groups was verified their expression difference by reverse transcription-quantitative polymerase chain reaction. Further, through the Liquid chromatography-mass spectrometry (LC-MS) approach, a total of 183 DEMs in various groups of the muscle samples and these DEMs such as Queuine and Keto-PGF1α, which demonstrated different abundance between the goat fast-growing group and slow-growing group. Through weighted correlation network analysis (WGCNA), the study correlated the DEGs with the DEMs and identified 4 DEGs modules associated with 18 metabolites. Conclusion This study benefits to dissection candidate genes and regulatory networks related to goat meat production performance, and the joint analysis of transcriptomic and metabolomic data provided insights into the study of goat muscle development.

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Section: Discussionmentioning

confidence: 98%

Transcriptomic and metabolomic dissection of skeletal muscle of crossbred Chongming white goats with different meat production performance

Lin,

Sun,

et al. 2024

BMC Genomics

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“…This protein exists in different types of skeletal muscle and mainly affects muscle development and IMF deposition. Furthermore, the increase of IMF content is positively correlated with increased TNNI1 abundance [ 39 , 40 ]. This is consistent with the results of this study, which demonstrated that the expression level of TNNI1 in the LD240 group was significantly higher than that in the LD120 group.…”

Section: Discussionmentioning

confidence: 99%

Integrated 4D Analysis of Intramuscular Fat Deposition: Quantitative Proteomic and Transcriptomic Studies in Wannanhua Pig Longissimus Dorsi Muscle

Li,

Xie,

et al. 2024

Animals

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Wannanhua (WH) is a pig breed indigenous to Anhui Province, China. This breed has a high intramuscular fat (IMF) content, making it an ideal model for investigating lipid deposition mechanisms in pigs. IMF content is one of the main indicators of meat quality in pigs and is regulated by multiple genes and metabolic pathways. Building upon our prior transcriptomic investigation, the present study focused on the longissimus dorsi muscle tissue of Wannanhua (WH) pigs in the rapid fat-deposition stages (120 and 240 days of age). Employing 4D label-free quantitative proteomic analysis, we identified 106 differentially expressed proteins (DEPs). Parallel reaction monitoring (PRM) technology was used to verify the DEPs, and the results showed that the 4D label-free results were reliable and valid. Functional enrichment and protein–protein interaction analyses showed that the DEPs were mainly involved in the skeletal-muscle-associated structural proteins, mitochondria, energy metabolism, and fatty acid metabolism. By integrating transcriptomic data, we identified seven candidate genes including ACADL, ACADM, ANKRD2, MYOZ2, TNNI1, UCHL1, and ART3 that play a regulatory role in fat deposition and muscle development. These findings establish a theoretical foundation for future analyses of lipid deposition traits, contributing to potential enhancements in pig meat quality during breeding and advancing the selection process for Chinese indigenous breeds.

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“…It has been demonstrated that MUSTN1 exhibits the highest expression level during the phase of duck muscle development associated with the maximum relative growth rate [31]. MYL3, TNNI1, and TNNI2 have been identified as key regulators of muscle contraction [32,33]. Consequently, these genes are expected to exhibit a positive correlation with the development of breast muscle in mink.…”

Section: Discussionmentioning

confidence: 99%

Muscle Transcriptome Analysis of Mink at Different Growth Stages Using RNA-Seq

Rong,

Xing,

Zhang

2024

Biology

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Mink is a kind of small and precious fur animal resource. In this study, we employed transcriptomics technology to analyze the gene expression profile of mink pectoral muscle tissue, thereby elucidating the regulatory mechanisms underlying mink growth and development. Consequently, a total of 25,954 gene expression profiles were acquired throughout the growth and development stages of mink at 45, 90, and 120 days. Among these profiles, 2607 genes exhibited significant differential expression (|log2(fold change)| ≥ 2 and p_adj < 0.05). GO and KEGG enrichment analyses revealed that the differentially expressed genes were primarily associated with the mitotic cell cycle process, response to growth factors, muscle organ development, and insulin resistance. Furthermore, GSEA enrichment analysis demonstrated a significant enrichment of differentially expressed genes in the p53 signaling pathway at 45 days of age. Subsequent analysis revealed that genes associated with embryonic development (e.g., PEG10, IGF2, NRK), cell cycle regulation (e.g., CDK6, CDC6, CDC27, CCNA2), and the FGF family (e.g., FGF2, FGF6, FGFR2) were all found to be upregulated at 45 days of age in mink, which suggested a potential role for these genes in governing early growth and developmental processes. Conversely, genes associated with skeletal muscle development (PRVA, TNNI1, TNNI2, MYL3, MUSTN1), a negative regulator of the cell cycle gene (CDKN2C), and IGFBP6 were found to be up-regulated at 90 days of age, suggesting their potential involvement in the rapid growth of mink. In summary, our experimental data provide robust support for elucidating the regulatory mechanisms underlying the growth and development of mink.

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Effects of feeding restriction on skeletal muscle development and functional analysis of TNNI1 in New Zealand white rabbits

Cited by 6 publications

References 32 publications

Transcriptomic and metabolomic dissection of skeletal muscle of crossbred Chongming white goats with different meat production performance

Transcriptomic and metabolomic dissection of skeletal muscle of crossbred Chongming white goats with different meat production performance

Integrated 4D Analysis of Intramuscular Fat Deposition: Quantitative Proteomic and Transcriptomic Studies in Wannanhua Pig Longissimus Dorsi Muscle

Muscle Transcriptome Analysis of Mink at Different Growth Stages Using RNA-Seq

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