Effects of Eyelid Warming Devices on Tear Film Parameters in Normal Subjects and Patients with Meibomian Gland Dysfunction

Arita, Reiko; Morishige, Naoyuki; Shirakawa, Rika; Sato, Yoichi; Amano, Shiro

doi:10.1016/j.jtos.2015.04.005

Cited by 79 publications

(87 citation statements)

References 43 publications

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“…Several studies [6–8] have reported the improvement in meibomian gland secretion after one 12-minute treatment by LipiFlow and the effects last up to one year. Tear film breakup time (TBUT) and symptom scores also showed improvement compared with traditional therapies [9–11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Monocular Treatment for Meibomian Gland Dysfunction with an Automated Thermodynamic System in Elderly Chinese Patients: A Contralateral Eye Study

Zhao

Xie²,

Li³

et al. 2016

Journal of Ophthalmology

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Purpose. To investigate the safety and efficacy of monocular treatment for elderly Chinese patients with meibomian gland dysfunction (MGD) with an automated thermodynamic system. Methods. This study was a prospective, examiner-masked, contralateral eye clinical trial. The eye perceived by the patient to be worse (test eye) received a 12-minute LipiFlow treatment, while the other eye served as control. All patients were examined before treatment and one week, one month, and three months after treatment. Clinical parameters included dry eye symptoms, lipid layer thickness (LLT), partial blink (PB) ratio, invasive tear breakup time (ITBUT) and cornea staining, Schirmer I test, meibomian glands yielding liquid secretion (MGYLS), and meibomian gland dropout. Results. A total of 29 patients were examined during the three-month follow-up. At each posttreatment visit, they had a significant reduction in dry eye symptoms accompanied by an increase of ITBUT and MGYLS and a reduction in corneal staining compared with the baseline parameters. There was a significant improvement in MGYLS and ITBUT in the test eye compared with the control eye. Other clinical parameters were not statistically significant. Conclusion. LipiFlow is an effective treatment for patients with MGD. Monocular treatment with LipiFlow may be a cost-effective treatment option to those afflicted with MGD in the developing world.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Monocular Treatment for Meibomian Gland Dysfunction with an Automated Thermodynamic System in Elderly Chinese Patients: A Contralateral Eye Study

Zhao

Xie²,

Li³

et al. 2016

Journal of Ophthalmology

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“…Various treatment options for MGD including the LipiFlow instrument, intense pulsed light, eyelid-warming devices, intraductal probing, as well as topical or oral application of drugs have been developed [11][12][13][14][15][16][17][18][19]. Our present results regarding additional instruction by nurses for improving the outcome of treatment with the Azuki-no-chikara eyelid-warming device may also be applicable to other treatment approaches.…”

Section: Resultsmentioning

confidence: 97%

“…We have previously reported that eyelid warming with Azuki-no-chikara improved tear film parameters in a different hospital [11]. Previous study basically included severe MGD patients thus the clinical parameters may be improved, thus it may not be adequate to compare these studies.…”

Section: Control Group Additional Instruction Groupmentioning

confidence: 99%

Additional Instruction by a Nurse Enhanced the Effect of Eyelid Warming on Subjective Symptoms in Patients with Meibomian Gland Dysfunction

T¹,

Ideta²,

Mera³

et al. 2018

J Healthc Commun

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“…Significant difference was found in sex between the two groups(P<0.01). MGD was diagnosed by the following evidence as previously reported[13]: 1) presence of ocular symptoms; 2) at least one lid margin abnormality including irregular lid margin, vascular engorgement, plugged meibomian gland orifices and anterior or posterior displacement of the mucocutaneous junction and 3) impaired meibum expression. Ocular symptom was determined by Ocular Surface Disease Index (OSDI), and the subject with score of > 12 was considered abnormal[14].…”

Section: Methodsmentioning

confidence: 99%

Impact of Chronic Smoking on Meibomian Gland Dysfunction

et al. 2016

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PurposeThe aim of this study was to explore the relationship between chronic cigarette smoking and meibomian gland dysfunction (MGD).MethodsThis study enrolled 322 smokers with MGD and 2067 non-smokers with MGD. All enrolled subjects were tested in the following sequence: Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), corneal fluorescein staining (CFS), Schirmer I test (SIT)and finally slit-lamp microscope examination of lid margin abnormalities, meibomian gland expression as well as meibum.ResultsCompared with the MGD patients without smoking, the MGD patients with smoking had significantly increased scores of lid margin abnormality and meibum (P<0.01 for each comparison). No significant difference was noted in OSDI, TBUT, CFS, SIT or the score of Meibomian gland expressibility between the smokers and non-smokers (P>0.05 for each comparison). In the smokers, the smoking index was significantly correlated with the scores of lid margin abnormality (Both sexes, R = 0.19, P<0.01; Male, R = 0.18, P<0.01) and meibum (Both sexes, R = 0.29, P<0.01; Male, R = 0.20, P<0.01), whereas it was not significantly correlated with OSDI, TBUT, CFS, SIT or score of Meibomian gland expressibility (P>0.05 for each comparison).ConclusionThe findings of this study suggest chronic smoking might be associated with MGD.

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Effects of Eyelid Warming Devices on Tear Film Parameters in Normal Subjects and Patients with Meibomian Gland Dysfunction

Abstract: Our results suggest that repeated eyelid warming with a non-wet device improves tear film function in normal individuals and may have beneficial effects on both tear film and meibomian gland function in MGD patients.

Cited by 79 publications

References 43 publications

Evaluation of Monocular Treatment for Meibomian Gland Dysfunction with an Automated Thermodynamic System in Elderly Chinese Patients: A Contralateral Eye Study

Evaluation of Monocular Treatment for Meibomian Gland Dysfunction with an Automated Thermodynamic System in Elderly Chinese Patients: A Contralateral Eye Study

Additional Instruction by a Nurse Enhanced the Effect of Eyelid Warming on Subjective Symptoms in Patients with Meibomian Gland Dysfunction

Impact of Chronic Smoking on Meibomian Gland Dysfunction

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