Effects of Exercise on Cancer-related Fatigue and Quality of Life in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Meta-analysis of Randomized Clinical Trials

Abstract

Objective To gain insight on how exercise affects the outcomes of prostate cancer patients treated with androgen deprivation therapy, specifically cancer-related fatigue (CRF) and quality of life (QoL).Methods Systematic searches for randomized clinical trials (RCTs) evaluating the effects of exercise on CRF and QoL of prostate cancer patients receiving androgen deprivation therapy were carried out to identify the eligible studies from EMBASE, PubMed and Cochrane library. Related data were extracted from eligible studies and then subjected to Reviewer Manage 5.3 for analysis. Standardized mean differences (SMD) and its 95% confidence interval (CI) were calculated.Results In all, 10 RCTs involving 841 prostate cancer patients (448 of whom exercised and 393 did not) were included in this study. With respect to CRF, there was good consistency among different studies, and it was remarkably reduced in the exercise group (SMD=−0.32, 95% CI: −0.45 to −0.18, P<0.00001, n=784). In regards to QoL, there was also good consistency among different studies, and it was also improved significantly in the exercise group (SMD=0.21, 95% CI: 0.08 to 0.34, P=0.002, n=841).Conclusion Exercise both reduced CRF and improved QoL in prostate cancer patients receiving androgen deprivation therapy.Chin Med Sci J 2017; 32(1):13-21

Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials

“…Twelve meta-analyses included only studies that involved cancer survivors who had lung resection,26 73 chemotherapy or radiation therapy,24 25 69 only chemotherapy,65 only radiation therapy,75 only androgen deprivation therapy,66 stem cell transplantation,53 60 induction therapy or postremission therapy80 and breast cancer surgery 52. The remaining meta-analyses did not use treatment stage or type as eligibility criteria and included a variety of treatment stages and types.…”

What is the minimal dose for resistance exercise effectiveness in prostate cancer patients? Systematic review and meta-analysis on patient-reported outcomes

“…The terms used were: 'prostate cancer' and 'resistance training' in association with a list of sensitive terms (Supplementary Material Table S1). In addition, we also performed a manual search of the reference lists provided in the selected papers as well as previous systematic reviews and meta-analytic studies in patients with prostate cancer [14][15][16][17][18][19] to detect studies potentially eligible for inclusion.…”

“…This is important given the role of resistance exercise to counter treatment-related toxicities in men with prostate cancer [2,12]. Furthermore, despite several systematic reviews examining exercise effects in prostate cancer patients [14][15][16][17][18][19], none have addressed the minimal exercise dosage required for improvements in common patient-reported outcomes.…”

Atividade Física E Qualidade De Vida Em Pacientes De Câncer De Próstata E Mama: Um Estudo Comparativo

“…Even, measuring physical activity level of men and women with cancer is extremely important for that new strategies that encourage its practice be implanted, acting beneficially in the physical 32 and psychological aspects, such as improvement of self-steem, depressive symptoms 22 and quality of life 33 . Besides that, accelerating the process of return to the daily activity and decreasing the risk of progression of the disease, reducing the mortality rates 34 , as during as after the treatment 35 . According to the findings of the present study, most of the patients, both breast and prostate cancer did not reach the necessary physical activity recommendations, thus, it becomes essential that new strategies and interventions be implanted for this public.…”