Effects of exercise on adiponectin and adiponectin receptor levels in rats

Zeng, Qin; Isobe, Kazumasa; Fu, Ling; Ohkoshi, Norio; Ohmori, Hitoshi; Takekoshi, Kazuhiro; Kawakami, Yasushi

doi:10.1016/j.lfs.2006.09.031

Cited by 51 publications

(50 citation statements)

References 27 publications

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“…In addition, a single exercise session did not affect blood adiponectin levels, as Ferguson et al reported, suggesting that long-term exercise, longer than 2 weeks, may be needed to increase the protein level 19) . We previously reported that AdipoR1 mRNA levels in muscles increased up to 4 -fold in response to exercise at a rate of 25 m/min for 30 min 5 days per week for 12 weeks 18) ; however, in this study, we could not observe such an effect with short-term exercise. Kim et al reported that an increase in muscle adiponectin receptor 1 mRNA was observed in animals that exercised for 3 weeks 20) .…”

Section: Discussioncontrasting

confidence: 96%

“…Both the treadmill speed and grade were gradually increased over the course of the training period to provide training overload throughout the training regimen. This training intensity was designed to elicit 75% (30 m/min for 60 min) maximal oxygen uptake based on previous work in adult rats 18) .…”

Section: Exercise Training Protocolmentioning

confidence: 99%

“…The mechanisms by which adiponectin levels are regulated during exercise are unknown. We previously reported that blood adiponectin levels increased by 150% in animals that exercised at a rate of 30 m/min for 60 min 2 days per week for 12 weeks and that AdipoR1 mRNA levels in muscle increased up to 4 times by exercise at a rate of 25 m/min for 30 min 5 days per week for 12 weeks 18) . In this study, we examined the effects of short-term exercise on blood adiponectin, adiponectin mRNA and tumor necrosis factor (TNF ) in adipose tissue, adiponectin receptor mRNA in muscle tissue, urinary catecholamine, and blood lipids levels.…”

Section: Introductionmentioning

confidence: 96%

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Effects of Short-Term Exercise on Adiponectin and Adiponectin Receptor Levels in Rats

Zeng

Takekoshi

et al. 2007

JAT

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Aim: Adiponectin reportedly reduces insulin resistance. Exercise has also been shown to lessen insulin resistance, although it is not well known whether exercise increases levels of adiponectin and/or its receptors nor whether it effects are dependent on exercise intensity and/or period. We previously reported that blood adiponectin levels increased by 150% in animals that exercised at a rate of 30 m/min for 60 minutes, 2 days per week, and adiponectin receptor 1 (AdipoR1) mRNA levels in muscle increased up to 4 times in response to exercise at a rate of 25 m/min for 30 min, 5 days per week for 12 weeks. Methods: In light of this information, we examined the effects of short-term exercise on adiponectin, and adiponectin receptor levels in rats, using ELISA and real-time PCR. Results: Our data showed that adiponectin mRNA levels in adipose tissue increased by 280% in rats exercised at a rate of 30 m/min for 60 minutes for 2 weeks and correlated with the exercise time periods. No effects of short-term exercise on adiponectin receptor 1 mRNA in muscle were observed. Conclusion: Thus, long-term exercise may be required to regulate adiponectin receptor 1 mRNA expression in muscle and adiponectin mRNA expression in adipose tissue.

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Section: Discussioncontrasting

confidence: 96%

Section: Exercise Training Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Effects of Short-Term Exercise on Adiponectin and Adiponectin Receptor Levels in Rats

Zeng

Takekoshi

et al. 2007

JAT

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“…Although some studies found that the concentration of circulating adiponectin increased after exercise (Lim et al, 2008;Kondo et al, 2006), in other studies, the concentration of circulating adiponectin was unchanged after exercise (Jürimäe et al, 2007;O'Leary et al, 2006;Klimcakova et al, 2006;Nassis et al, 2005;Hara et al, 2005). Likewise, some studies have reported that the concentration of circulating adiponectin in healthy and diabetic rodents increased after exercise (Zeng et al, 2007;Lee et al, 2011), whereas in other studies, the concentration of circulating adiponectin in healthy rodents was unchanged after exercise (Lee et al, 2011;Bhattacharya et al, 2005;Huang et al, 2007).…”

Section: Exercise Alters Adipokine Secretionmentioning

confidence: 98%

Exercise-induced adaptations to white and brown adipose tissue

Lehnig

Stanford

2018

Journal of Experimental Biology

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The beneficial effects of exercise on skeletal muscle and the cardiovascular system have long been known. Recent studies have focused on investigating the effects of exercise on adipose tissue and the effects that these exercise-induced adaptations have on overall metabolic health. Examination of exercise-induced adaptations in both white adipose tissue (WAT) and brown adipose tissue (BAT) has revealed marked differences in each tissue with exercise. In WAT, there are changes to both subcutaneous WAT (scWAT) and visceral WAT (vWAT), including decreased adipocyte size and lipid content, increased expression of metabolic genes, altered secretion of adipokines and increased mitochondrial activity. Adaptations specific to scWAT include lipidomic remodeling of phospholipids and, in rodents, the beiging of scWAT. The changes to BAT are less clear: studies evaluating the effect of exercise on the BAT of humans and rodents have revealed contradictory data, making this an important area of current investigation. In this Review, we discuss the exerciseinduced changes to WAT and BAT that have been reported by different studies and highlight the current questions in this field.

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“…Zeng et al showed that changes of adiponectin in response to exercise depend on the intensity, duration and frequency of training [15]. While Ferguson et al showed that a single bout of exercise with 65% HRmax intensity in men and women did not significantly increase the concentration of plasma adiponectin [16].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ten Weeks of Aerobic Interval Training and Four Weeks Detraining on Plasma Adiponectin Level in Male Student Non-Athletes

Dehghani

Mogharnasi

2015

Zahedan J Res Med Sci

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Background: Adipose a protein secreted by adipose tissue that plays an important role in inflammatory mechanisms and hyperglycemia. Objectives: This study investigated the effect of 10 weeks aerobic interval training and 4 weeks detraining on plasma adiponectin levels in young male non-athletes. Materials and Methods:In this quasi-experimental study, 26 male non-athlete students of Sistan and Baluchestan university were selected randomly and were divided into two groups. The experimental group carried out the aerobic interval training for 10 weeks, three times a week with an intensity of 55 to 85 (HRmax). Then subjects experience 4 weeks of detraining so the effects could be investigated. After 14 hours of fasting, blood samples were taken at different stages of the same condition and plasma adiponectin levels were measured using adiponectin kit manufactured by BOSTER company in America. The data were analyzed using Kolmogorov-Smirnov test ANOVA with repeated measurements LSD post hoc test and t-test at a significance level of P ≤ 0.05 Results: The results showed that 10 weeks of aerobic interval training led to a significant increase in plasma adiponectin levels in the experimental group compared to the control group (P = 0.001). The results also showed that after 4 weeks of detraining, the level of adiponectin was significantly reduced due to the discontinuation of the exercise (P = 0.001). Conclusions:We can conclude that aerobic interval as an effective and beneficial training method with more variety and less fatigue, with a significant increase in plasma adiponectin, cardiovascular protective factor, has a preventive effect on cardiovascular disease.

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Effects of exercise on adiponectin and adiponectin receptor levels in rats

Cited by 51 publications

References 27 publications

Effects of Short-Term Exercise on Adiponectin and Adiponectin Receptor Levels in Rats

Effects of Short-Term Exercise on Adiponectin and Adiponectin Receptor Levels in Rats

Exercise-induced adaptations to white and brown adipose tissue

Effects of Ten Weeks of Aerobic Interval Training and Four Weeks Detraining on Plasma Adiponectin Level in Male Student Non-Athletes

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